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Alkaloids

Jervine

Also known as Jerwiny, jervin, Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-

CAS 469-59-0Formula C27H39NO3Molar mass 425.61 g/molEC 207-417-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 10 suppliers listed
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Jervine chemical structure, C27H39NO3, CAS 469-59-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Needles from methanol + water
Melting point
243.5 to 244.5
Solubility
SOL IN ALCOHOL, ACETONE, CHLOROFORM
HS code
293979
Category
Alkaloids
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Jervine?

Plain description, key identifiers and synonyms

Jervine is a member of piperidines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethylspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one
CAS number
469-59-0 CAS number cross-checked
EC number
207-417-9
Molecular formula
C27H39NO3
UNII
19V3ECX465
MDL number
MFCD01684066
InChIKey
CLEXYFLHGFJONT-DNMILWOZSA-N
InChI
InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
Canonical SMILES
CC1=C2C(=O)C3C(CC=C4CC(O)CCC43C)C2CCC12OC1CC(C)CNC1C2C
Isomeric SMILES
C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5C(=O)C4=C3C)C)O)C)NC1

Synonyms

  • Jerwiny
  • jervin
  • Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3beta,23beta)-
  • 17,23 beta-epoxy-3 beta-hydroxyveratraman-11-one
  • 11-Ketocyclopamine
  • Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3-beta,23-beta)-
  • Veratraman-11-one,23-epoxy-3-hydroxy-, (3beta,23beta)-
  • Jervine?
  • 17,23beta-Epoxy-3beta-hydroxyveratraman-11-one
  • Spiro[9H-benzo[a]fluorene-9,2-b]-pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-
  • Jervine (Standard)
  • JervineJerwiny
  • (3beta,23beta)-17,23-Epoxy-3-hydroxyveratraman-11-one
  • 4-27-00-03590 (Beilstein Handbook Reference)
  • (3|A, 23|A)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine
  • Jervine, >=98% (HPLC), powder
  • (3?,23?)-17,23-Epoxy-3-hydroxyveratraman-11-one
  • (3|?,23|?)-17,23-Epoxy-3-hydroxyveratraman-11-one
  • (22S,23R)-3beta-Hydroxy-17beta-17,23-epoxyveratraman-11-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Needles from methanol + waterexp.
Melting point
243.5 to 244.5exp.
Solubility
SOL IN ALCOHOL, ACETONE, CHLOROFORMexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
425.61 g/molcalc.
Exact mass
425.293 Dacalc.
LogP (octanol/water)
4.18calc.
Topological polar surface area
58.56 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
31calc.
Rings
6calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.82calc.
Formal charge
0calc.
Stereocentres
10calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C2=CC3(CCC2C2CC=C4CCCCC4C12)CC1NCCCC1O3

O=C1C2=CC3(CCC2C2CC=C4CCCCC4C12)CC1NCCCC1O3

6 rings, 26 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Jervine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 10 suppliers
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Where suppliers are based

10 suppliers in 3 countries

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Jervine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • Hedgehog signaling pathway inhibitor
  • aetiopathogenetic role
  • anti-inflammatory agent
  • antifungal agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • apoptosis inducer
  • autophagy inducer
  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • pathway inhibitor
  • pharmaceutical
  • plant metabolite
  • teratogenic agent

How it is made

Total synthesis: kutney et al, can j chem 53, 1796 (1975).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Jervine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Jervine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Jervine, based on the data on this page

What is Jervine?

Jervine is a member of piperidines.

What is the CAS number of Jervine?

The CAS registry number of Jervine is 469-59-0.

What is the molecular formula and weight of Jervine?

The molecular formula of Jervine is C27H39NO3 and its molar mass is 425.61 g/mol.

What is Jervine used for?

Known uses and roles of Jervine include hedgehog signaling pathway inhibitor, aetiopathogenetic role, anti-inflammatory agent, antifungal agent, antimicrobial agent and 11 more.

Is Jervine hazardous?

Jervine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Jervine?

Jervine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Jervine?

CompoundList lists 10 suppliers of Jervine in United States, China and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Jervine?

Suppliers quote Jervine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Jervine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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