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Analgesics and anti-inflammatories

Ketorolac

Also known as Ketorolaco, Ketorolacum, (+-)-Ketorolac

CAS 74103-06-3Formula C15H13NO3Molar mass 255.27 g/molEC 616-049-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 86 suppliers listed Drug substance
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Ketorolac chemical structure, C15H13NO3, CAS 74103-06-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
74103-06-3
Formula
C15H13NO3
Molar mass
255.27 g/mol
EC number
616-049-1
HS code
293399
Category
Analgesics and anti-inflammatories

What is Ketorolac?

Plain description, key identifiers and synonyms

Ketorolac is a racemate comprising equimolar amounts of (R)-(+)- and (S)-()-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-() enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. It has a role as a non-steroidal anti-inflammatory drug, an analgesic, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor. It contains a (R)-ketorolac and a (S)-ketorolac. It is a conjugate acid of a ketorolac(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS number
74103-06-3 CAS number cross-checkedOther or deprecated CAS: 66635-83-4
EC number
616-049-1
Molecular formula
C15H13NO3
UNII
YZI5105V0L
MDL number
MFCD00864281
InChIKey
OZWKMVRBQXNZKK-UHFFFAOYSA-N
InChI
InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
SMILES (canonical and isomeric)
C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O

Synonyms

  • Ketorolaco
  • Ketorolacum
  • (+-)-Ketorolac
  • rac-ketorolac
  • (+-)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-
  • 5-(benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro
  • 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • Ketoralac
  • RS 37619
  • Ketorolac (INN)
  • Toradol (TN)
  • (1RS)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • Macril
  • 5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • rac Ketorolac
  • 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (.+/-.)-
  • 5-Benzoyl-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid
  • 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-
  • Ketorolac (NSAID)
  • Ketorolac (Standard)
  • Sdccgsbi-0050655.p004
  • Ketorolac Solution in Acetonitrile, 100ug/mL
  • 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylicacid
Show all 29 synonyms
  • KETOROLAC, ketorolactromethamine, Ketorolac Tromethamine
  • 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid #
  • rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
  • (+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
255.27 g/molcalc.
Exact mass
255.0895 Dacalc.
LogP (octanol/water)
2.29calc.
Topological polar surface area
59.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccc1)c1ccc2n1CCC2

O=C(c1ccccc1)c1ccc2n1CCC2

3 rings, 16 atoms, the Phenyl(2,3-dihydro-1H-pyrrolizin-5-yl)methanone ring system.

69 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ketorolac suppliers

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All 86 suppliers
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Where suppliers are based

86 suppliers in 13 countries

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Ketorolac price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antibacterial agent
  • antimicrobial agent
  • antineoplastic agent
  • antirheumatic drug
  • cardiovascular drug
  • cyclooxygenase 1 inhibitor
  • cyclooxygenase 2 inhibitor
  • enzyme inhibitor
  • non-steroidal anti-inflammatory drug
  • ophthalmology drug
  • pharmaceutical
  • vulnerary

Functional uses

  • Pharmaceutical

Pharmacology

Ketorolac is a Nonsteroidal Anti-inflammatory Drug and Cyclooxygenase Inhibitor. The mechanism of action of ketorolac is as a Cyclooxygenase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ketorolac is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ketorolac is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ketorolac, based on the data on this page

What is Ketorolac?

Ketorolac is a racemate comprising equimolar amounts of (R)-(+)- and (S)-()-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-() enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity.

What is the CAS number of Ketorolac?

The CAS registry number of Ketorolac is 74103-06-3. Other or deprecated CAS numbers: 66635-83-4.

What is the molecular formula and weight of Ketorolac?

The molecular formula of Ketorolac is C15H13NO3 and its molar mass is 255.27 g/mol.

What is Ketorolac used for?

Use classes: Pharmaceuticals.

Is Ketorolac hazardous?

Ketorolac carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ketorolac?

Ketorolac is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ketorolac?

CompoundList lists 86 suppliers of Ketorolac in China, United States, United Kingdom, India and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ketorolac in India?

5 suppliers in India list Ketorolac on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ketorolac?

Suppliers quote Ketorolac on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ketorolac

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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