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Central nervous system drugs

Lasmiditan

Also known as 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide, COL 144

CAS 439239-90-4Formula C19H18F3N3O2Molar mass 377.37 g/mol
13 suppliers listed Drug substance
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Lasmiditan chemical structure, C19H18F3N3O2, CAS 439239-90-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
439239-90-4
Formula
C19H18F3N3O2
Molar mass
377.37 g/mol
HS code
293339
Category
Central nervous system drugs

What is Lasmiditan?

Plain description, key identifiers and synonyms

Lasmiditan is a small molecule selective agonist of the serotonin 1F [5HT1F] receptor which decreases neuron activity that is thought to mediate pain and inflammation associated with migraine headaches. In clinical trials, lasmiditan was found to shorten the duration of migraine headache pain and other associated symptoms. Lasmiditan is generally well tolerated and has been associated with only rare instances of transient serum aminotransferase elevations during therapy but with no instances of clinically apparent liver injury.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridinyl]benzamide
CAS number
439239-90-4 CAS number cross-checked
Molecular formula
C19H18F3N3O2
UNII
760I9WM792
MDL number
MFCD18633238
InChIKey
XEDHVZKDSYZQBF-UHFFFAOYSA-N
InChI
InChI=1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27)
SMILES (canonical and isomeric)
CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F

Synonyms

  • 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide
  • 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide
  • COL 144
  • lasmiditanum
  • 2,4,6-trifluoro-n-(6-((1-methylpiperidin-4-yl)carbonyl)pyridin-2yl)benzamide
  • Reyvow
  • lasmitidan
  • 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide
  • 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridinyl]benzamide
  • 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide
  • 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide
  • 2,4,6-Trifluoro-N-{6-[(1-methylpiperidine-4-yl)carbonyl]pyridin-2-yl}benzamide
  • Benzamide, 2,4,6-trifluoro-N-(6-((1-methyl-4-piperidinyl)carbonyl)-2-pyridinyl)-
  • Benzamide, 2,4,6-trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]-
  • 2,4,6-Trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide, 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]benzamide
  • 439239-90-4 (free base)
  • Lasmiditan (USAN/INN)
  • DEA NO. 2790
  • Lasmiditan, OL-144, LY573144
  • COL-144, LY573144
  • Lasmiditan (COL-144, LY573144)
  • Lasmiditan (COL-144, LY573144)?
  • 2,4,6-trifluoro-N-[6-(1-methyl-piperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide
  • 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide
  • 2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]-benzamide
Show all 27 synonyms
  • 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]benzamide
  • COL 144, LY 573144, 2,4,6-trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
377.37 g/molcalc.
Exact mass
377.1351 Dacalc.
LogP (octanol/water)
3.28calc.
Topological polar surface area
62.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
27calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1cccc(C(=O)C2CCNCC2)n1)c1ccccc1

O=C(Nc1cccc(C(=O)C2CCNCC2)n1)c1ccccc1

3 rings, 23 atoms.

12 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Lasmiditan suppliers

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All 13 suppliers
13 of 13 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

13 suppliers in 5 countries

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Lasmiditan price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Serotonin Receptor Agonists

Regulatory status

Inventories, regulations and trade controls that list this substance

Controls

  • US DEA controlled substance or listed chemical

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Lasmiditan is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Lasmiditan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Lasmiditan, based on the data on this page

What is Lasmiditan?

Lasmiditan is a small molecule selective agonist of the serotonin 1F [5HT1F] receptor which decreases neuron activity that is thought to mediate pain and inflammation associated with migraine headaches.

What is the CAS number of Lasmiditan?

The CAS registry number of Lasmiditan is 439239-90-4.

What is the molecular formula and weight of Lasmiditan?

The molecular formula of Lasmiditan is C19H18F3N3O2 and its molar mass is 377.37 g/mol.

What is Lasmiditan used for?

Known uses and roles of Lasmiditan include cns agents in pharmaceuticals and serotonin receptor agonists.

Is Lasmiditan hazardous?

No GHS hazard classification for Lasmiditan is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Lasmiditan?

Lasmiditan is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Lasmiditan?

CompoundList lists 13 suppliers of Lasmiditan in China, Canada, Ireland, India and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Lasmiditan in India?

1 supplier in India list Lasmiditan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Lasmiditan?

Suppliers quote Lasmiditan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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