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Respiratory, allergy and digestive drugs

Loratadine

Also known as Claritin, Clarityn, Alavert

CAS 79794-75-5Formula C22H23ClN2O2Molar mass 382.89 g/molEC 616-734-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 206 suppliers listed Drug substance
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Loratadine chemical structure, C22H23ClN2O2, CAS 79794-75-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
79794-75-5
Formula
C22H23ClN2O2
Appearance
Crystals from acetonitrile
Melting point
134 to 136
HS code
293339
Category
Respiratory, allergy and digestive drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Loratadine?

Plain description, key identifiers and synonyms

Loratadine is a benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. It has a role as a geroprotector, a H1-receptor antagonist, a cholinergic antagonist and an anti-allergic agent. It is a tertiary carboxamide, an ethyl ester, an organochlorine compound, a N-acylpiperidine and a benzocycloheptapyridine. It is functionally related to a desloratadine.

Loratadine is a medication used to treat allergies.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
CAS number
79794-75-5 CAS number cross-checked
EC numbers
616-734-5, 935-907-9
Molecular formula
C22H23ClN2O2
UNII
7AJO3BO7QN
MDL number
MFCD00672869
InChIKey
JCCNYMKQOSZNPW-UHFFFAOYSA-N
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
SMILES (canonical and isomeric)
CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

Synonyms

  • Claritin
  • Clarityn
  • Alavert
  • Clarityne
  • Fristamin
  • Lisino
  • Bonalerg
  • Loracert
  • Loradex
  • Claritine
  • Histaloran
  • Lertamine
  • Lorastine
  • Loratyne
  • Sensibit
  • Civeran
  • Loranox
  • Claritin Reditabs
  • Aerotina
  • Alerpriv
  • Anhissen
  • Claratyne
  • Loratadina
  • Loritine
  • Restamine
Show all 38 synonyms
  • Biloina
  • Nularef
  • Sch 29851
  • Loratadine Redidose
  • Children's Claritin
  • Loratadinum
  • Roletra
  • Claritin Hives Relief
  • Claritin Hives Relief Reditab
  • Clarityn rapide
  • Hay-rite
  • Topcare childrens allergy relief
  • ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetonitrileexp.
Melting point
134 to 136exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
382.89 g/molcalc.
Exact mass
382.1448 Dacalc.
LogP (octanol/water)
4.89calc.
Topological polar surface area
42.43 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1

c1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1

4 rings, 21 atoms, the N-Desmethyl azatadine ring system.

90 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H341Suspected of causing genetic defects.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Loratadine suppliers

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All 206 suppliers
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Where suppliers are based

206 suppliers in 30 countries

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Loratadine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antihistaminic.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Antipruritics
  • Histamine H1 Antagonists, Non-Sedating

Roles

  • H1-receptor antagonist
  • analgesic
  • antagonist
  • anti-allergic agent
  • anti-asthmatic agent
  • antimicrobial agent
  • antineoplastic agent
  • antirheumatic drug
  • antiviral agent
  • cholinergic antagonist
  • cholinergic drug
  • dermatologic drug
  • geroprotector
  • histamine antagonist
  • histaminergic drug
  • immunomodulator
  • immunosuppressive agent
  • neurotransmitter agent
  • pharmaceutical
  • protective agent

Pharmacology

Loratadine is a piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.

How it is made

Prepn: F.J. Villani, US pat. 4,282,233 (1981 to Schering), F.J. Villani et al., Arzneimittel-Forsch. 36, 1311 (1986).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Loratadine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Loratadine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Loratadine, based on the data on this page

What is Loratadine?

Loratadine is a benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.

What is the CAS number of Loratadine?

The CAS registry number of Loratadine is 79794-75-5.

What is the molecular formula and weight of Loratadine?

The molecular formula of Loratadine is C22H23ClN2O2 and its molar mass is 382.89 g/mol.

What is Loratadine used for?

Antihistaminic. Use classes: Pharmaceuticals.

Is Loratadine hazardous?

Loratadine carries the GHS signal word "Warning". Main hazards: causes skin irritation, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Loratadine?

Loratadine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Loratadine?

CompoundList lists 206 suppliers of Loratadine in India, United States, China, Spain and 26 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Loratadine in India?

51 suppliers in India list Loratadine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Loratadine?

Suppliers quote Loratadine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Loratadine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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