M-Cresol
Also known as 3-methylphenol, Metacresol, Phenol, 3-methyl-
Key facts
What buyers check first
- Appearance
- Colorless, yellowish liquid
- Melting point
- 12.2 °C
- Boiling point
- 202.2 °C
- Density
- Relative density (water = 1): 1.03
- Flash point
- 86 °C
- HS code
- 290712
- Category
- Synthetic aroma chemicals
- UN number
- UN 2076
What is M-Cresol?
Plain description, key identifiers and synonyms
M-cresol is a cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene. It has a role as a human xenobiotic metabolite.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 3-methylphenol
- CAS number
- 108-39-4 CAS number cross-checkedOther or deprecated CAS: 27289-33-4
- EC number
- 203-577-9
- Molecular formula
- C7H8O
- UNII
- GGO4Y809LO
- MDL number
- MFCD00002302
- INCI name
- M-CRESOL
- InChIKey
- RLSSMJSEOOYNOY-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H8O/c1-6-3-2-4-7(8)5-6/h2-5,8H,1H3
- SMILES (canonical and isomeric)
- CC1=CC(=CC=C1)O
Synonyms
- 3-methylphenol
- Metacresol
- Phenol, 3-methyl-
- 3-hydroxytoluene
- meta-cresol
- m-methylphenol
- 3-cresol
- m-kresol
- m-cresylic acid
- m-toluol
- 1-hydroxy-3-methylbenzene
- m-oxytoluene
- m-Hydroxytoluene
- Franklin Cresolis
- 1-Methyl-3-hydroxybenzene
- Rover's Dog Shampoo
- m-Cresole
- hydroxy-3-methylbenzene
- 3-methyl phenol
- 3-methyl-1-hydroxybenzene
- Celcure Dry Mix (chemicals for wood preserving)
- meta-cresylic acid
- Cresol, m-
- Cresol, meta
- m-cresylic
Show all 36 synonymsShow fewer synonyms
- m-Cresol, 99%
- Toluene,3-hydroxy (meta-cresol)
- Metacresol (3-Methylphenol)
- CRS
- meta cresol
- Cresol, m-isomer
- Metacresol, 3-Methylphenol, Amylmetacresol Impurity B
- 3methylphenol
- 3-methyl-phenol
- Cresol,m-
- Metacresol (USP)
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Colorless, yellowish liquidexp.Measured value |
|---|---|
| Odour | Phenolic odorexp.Measured value |
| Taste | Taste threshold: 2.00 × 10⁻³ ppmexp.Measured value |
| Melting point | 12.2 °Cexp.Measured value |
| Boiling point | 202.2 °Cexp.Measured value |
| Density | Relative density (water = 1): 1.03exp.Measured value |
| Flash point | 86 °Cexp.Measured value |
| Autoignition temperature | 558 °Cexp.Measured value |
| Solubility | In water, 2.22 × 10⁺⁴ mg/L at 25 °Cexp.Measured value |
| Vapour pressure | 0.11 mm Hg at 25 °Cexp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 108.14 g/molcalc.Computed value |
|---|---|
| Exact mass | 108.0575 Dacalc.Computed value |
| LogP (octanol/water) | 1.7calc.Computed value |
| Topological polar surface area | 20.23 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 1calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 8calc.Computed value |
| Rings | 1calc.Computed value |
| Aromatic rings | 1calc.Computed value |
| Fraction sp3 carbons | 0.14calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H301Toxic if swallowed.
- H311Toxic in contact with skin.
- H314Causes severe skin burns and eye damage.
Precautionary statements (18)
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P262Do not get in eyes, on skin, or on clothing.
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P316If swallowed: Get emergency medical help immediately.
- P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
- P302 + P352If on skin: Wash with plenty of water.
- P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P316Get emergency medical help immediately.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
- P363Wash contaminated clothing before reuse.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
- UN number
- UN 2076
- Transport hazard class
- 6.1
- Packing group
- II
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidM-Cresol suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- Japan, Chuo-Ku ManufacturerUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- Poland, WarszawaUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- China, NanjingUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- Price on request
- ChinaUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- China, TianjinUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- United StatesUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profileM-CresolGrade, purity and minimum order on requestPrice on request
- Price on request
- Switzerland, LausanneUnclaimed profileMeta cresolGrade, purity and minimum order on requestPrice on request
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Where suppliers are based
85 suppliers in 13 countries
- China33
- India19
- United States19
- Japan3
- Germany2
- United Kingdom2
- and 7 more countries
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M-Cresol price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
M-Cresol and xylenol were registered by the Agency for use in the United States in 1980 for use as a bactericide for control of crown gall and olive knot on certain fruit and nut trees and ornamentals and the genetic/physiological disorder burr knot on apples. Currently, one product is registered which contains both m-cresol and xylenol.
For making synthetic resins, in disinfectants and fumigants, as industrial solvent, m-cresol in photographic developers, explosives.
Chemical intermediate for thymol used in cough/cold medicinals, synthetic pyrethroid insecticides, 3-methyl-6-t-butylphenol, trinitro-m-cresol for explosives, & phenolic resins (possible use), disinfectant ingredient (possible use), ore flotation agent (possible use), solvent (eg, for wire enamel).
Industrial uses: Catalyst, Corrosion inhibitor, Cleaning agent, Fragrance, Dye, Intermediate, Other, Solvent.
Consumer uses: Binder, Solvent, Cleaning agent, Fragrance.
Use classes: Cosmetics.
Industries and functions
Cosmetic ingredient, INCI name M-CRESOL(antimicrobial, perfuming)
Roles
- animal metabolite
- eukaryotic metabolite
- human metabolite
- human xenobiotic metabolite
- mammalian metabolite
- metabolite
- xenobiotic metabolite
Functional uses
- Biocide
- Flavouring and nutrient
- Fragrance
- Solvent
Cosmetic functions
- Antimicrobial
- Perfuming
How it is made
M-Cresol is produced synthetically from toluene. Toluene is chlorinated and the resulting chlorotoluene is hydrolyzed to a mixture of methylphenols. Purification by distillation gives a mixture of 3-methylphenol and 4-methylphenol since they have nearly identical boiling points. Reaction of this mixture with isobutylene under acid catalysis forms 2,6-di-tert-butyl-4-methylphenol and 2,4-di-tert-butyl-5-methylphenol, which can then be separated by fractional distillation and debutylated to give the corresponding 3- and 4-methylphenols.
Read more
A mixture of 3- and 4-methylphenols is also derived from petroleum crude and coal tars.
By fractional distillation of crude cresol (from coal tar), also synthetically. Method of purification: rectification.
M-Cresol is prepared from m-toluic acid or obtained from coal tar or petroleum. Crude cresol is obtained by distilling "gray phenic acid" at a temperature of 180 to 201 °C. The m-cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine, or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.
Regulatory status
Inventories, regulations and trade controls that list this substance
Europe
- EU harmonised classification (CLP Annex VI)Index no: 604-004-00-9[1]
Health and food
- EU cosmetic ingredient inventory
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code M-Cresol is traded under.
Cresols and their salts
- United Kingdom21.3%
- India * partner reported14.2%
- Germany13.4%
* Partner reported figures, a lower bound.
The HS code shown for M-Cresol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about M-Cresol, based on the data on this page
What is M-Cresol?
What is the CAS number of M-Cresol?
What is the molecular formula and weight of M-Cresol?
What is M-Cresol used for?
Is M-Cresol hazardous?
What is the HS code of M-Cresol?
Where can I buy M-Cresol?
Where can I buy M-Cresol in India?
What is the price of M-Cresol?
Guides for buyers
Practical guides that help when you source, ship or handle M-Cresol
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, Trade and logisticsShipping dangerous goods: UN numbers, classes and packing groupsHow the UN dangerous goods system works for chemicals, from the nine classes and UN numbers to packing groups, UN packaging marks, labels, documents and segregation.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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