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Synthetic aroma chemicals

P-Cresol

Also known as 4-Methylphenol, 4-Cresol, 4-Hydroxytoluene

CAS 106-44-5Formula C7H8OMolar mass 108.14 g/molEC 203-398-6
GHS signal word: Danger. Pictograms: Corrosive, Acute toxicity (severe) 108 suppliers listed
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P-Cresol chemical structure, C7H8O, CAS 106-44-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystalline solid [Note: A liquid above 95 degees F]
Melting point
34.8 °C
Boiling point
201.9 °C
Density
1.02 g/cm³
Flash point
85 °C
HS code
290712
Category
Synthetic aroma chemicals
UN number
UN 2076
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is P-Cresol?

Plain description, key identifiers and synonyms

P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, an Escherichia coli metabolite and a human metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-methylphenol
CAS number
106-44-5 CAS number cross-checkedOther or deprecated CAS: 27289-34-5, 2876-02-0
EC number
203-398-6
Molecular formula
C7H8O
UNII
1MXY2UM8NV
MDL number
MFCD00002376
INCI name
MIXED CRESOLS, P-CRESOL
InChIKey
IWDCLRJOBJJRNH-UHFFFAOYSA-N
InChI
InChI=1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3
SMILES (canonical and isomeric)
CC1=CC=C(C=C1)O

Synonyms

  • 4-Methylphenol
  • 4-Cresol
  • 4-Hydroxytoluene
  • p-Methylphenol
  • p-Hydroxytoluene
  • p-Tolyl alcohol
  • Phenol, 4-methyl-
  • para-Cresol
  • p-Kresol
  • p-Toluol
  • p-Oxytoluene
  • p-Cresylic acid
  • Paracresol
  • 1-Hydroxy-4-methylbenzene
  • p-Methylhydroxybenzene
  • 1-Methyl-4-hydroxybenzene
  • Paramethyl phenol
  • 4-methyl phenol
  • RCRA waste number U052
  • para-Cresylic acid
  • Cresol, para-
  • Cresol, p-
  • 4-methyl-phenol
  • Cresol, p-isomer
  • Cresol, para
Show all 37 synonyms
  • p-Methyl phenol
  • 4-methylphenol (p-cresol)
  • 4-Methylphenol Standard
  • Toluene,4-hydroxy (para-cresol)
  • p-Cresol [UN2076] [Poison, Corrosive]
  • p-Cresol-methyl-13c
  • para cresol
  • rho-cresol
  • p-Cresylate
  • p-methyl-phenol
  • Cresol,p-
  • Phenol, 4-methyI

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalline solid [Note: A liquid above 95 degees F]exp.
Odour
Phenolic odorexp.
Melting point
34.8 °Cexp.
Boiling point
201.9 °Cexp.
Density
1.02 g/cm³exp.
Flash point
85 °Cexp.
Autoignition temperature
558 °Cexp.
Solubility
In water, 2.15 × 10⁺⁴ mg/L at 25 °Cexp.
Vapour pressure
0.11 mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
108.14 g/molcalc.
Exact mass
108.0575 Dacalc.
LogP (octanol/water)
1.7calc.
Topological polar surface area
20.23 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.14calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
230NFPA 704 rating

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H314Causes severe skin burns and eye damage.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P352If on skin: Wash with plenty of water.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P363Wash contaminated clothing before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2076
Transport hazard class
6.1
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

P-Cresol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 108 suppliers
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Where suppliers are based

108 suppliers in 19 countries

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P-Cresol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Chemical intermediate for tricresyl phosphate & cresyl diphenyl phosphate, agent in production of disinfectants, explosives, & synthetic perfumery materials, metal cleaning agent, solvent for wire enamels, agent in ore flotation, monomer for phenolic resins.

Organic sulfur is removed from coal by extraction with p-cresol.

P-Cresol has been used in synthetic resins, explosive, petroleum, photographic, paint and agricultural industries.

For making synthetic resins, in disinfectants and fumigants, as industrial solvent.

Industrial uses: Dye, Intermediate, Processing aids, specific to petroleum production, Catalyst, Corrosion inhibitor, Cleaning agent, Fragrance.

Consumer uses: Solvent, Binder, Processing aids, specific to petroleum production, Intermediate, Cleaning agent, Fragrance.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name MIXED CRESOLS(antimicrobial, perfuming)

Roles

  • Escherichia coli metabolite
  • animal metabolite
  • bacterial metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • poison
  • prokaryotic metabolite
  • toxin
  • uremic toxin

Functional uses

  • Biocide
  • Flavouring and nutrient
  • Fragrance
  • Preservative
  • Solvent

Cosmetic functions

  • Antimicrobial
  • Perfuming

How it is made

From benzene by the cumene process. Method of purification: crystallization.

P-Cymene is oxidized and cleaved to produce p-cresol and acetone

Para-cresol is prepared synthetically by methylation of phenol using methanol or by fusion hydrolysis of toluenesulfonic acid

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 604-004-00-9[3]

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code P-Cresol is traded under.

HS 2907.12Indicative HS code

Cresols and their salts

World exports in 2024
$249M
+21.8% vs 2023, imports $185M
2019 to 2024
Top exporters
  1. Italy23.9%
  2. Germany23.2%
  3. India * partner reported14.9%
Top importers
  1. United Kingdom21.3%
  2. India * partner reported14.2%
  3. Germany13.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for P-Cresol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about P-Cresol, based on the data on this page

What is P-Cresol?

P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, an Escherichia coli metabolite and a human metabolite.

What is P-Cresol used for?

Chemical intermediate for tricresyl phosphate & cresyl diphenyl phosphate, agent in production of disinfectants, explosives, & synthetic perfumery materials, metal cleaning agent, solvent for wire enamels, agent in ore flotation, monomer for phenolic resins.

Is P-Cresol hazardous?

P-Cresol carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin, causes severe skin burns and eye damage. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle P-Cresol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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