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Screening compounds

Mapracorat

Also known as (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol, mapracoratum, (2R)-1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-(((2-methylquinolin-5-yl)amino)methyl)pentan-2-ol

CAS 887375-26-0Formula C25H26F4N2O2Molar mass 462.49 g/molEC 690-739-0
GHS signal word: Warning. Pictograms: Serious health hazard 2 suppliers listed
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Mapracorat chemical structure, C25H26F4N2O2, CAS 887375-26-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
887375-26-0
Formula
C25H26F4N2O2
Molar mass
462.49 g/mol
EC number
690-739-0
HS code
293499
Category
Screening compounds

What is Mapracorat?

Plain description, key identifiers and synonyms

Mapracorat is an aminoquinoline.

Mapracorat is a type of selective glucocorticoid receptor agonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol
CAS number
887375-26-0 CAS number cross-checked
EC number
690-739-0
Molecular formula
C25H26F4N2O2
UNII
145V79YBVP
MDL number
MFCD19443722
InChIKey
VJGFOYBQOIPQFY-XMMPIXPASA-N
InChI
InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1
Canonical SMILES
Cc1ccc2c(NCC(O)(CC(C)(C)c3cc(F)cc4c3OCC4)C(F)(F)F)cccc2n1
Isomeric SMILES
CC1=NC2=C(C=C1)C(=CC=C2)NC[C@](CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O

Synonyms

  • (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol
  • mapracoratum
  • (2R)-1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-(((2-methylquinolin-5-yl)amino)methyl)pentan-2-ol
  • BOL 303242-X
  • (2R)-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-1-((2-methylquinolin-5-yl)amino)-2-(trifluoromethyl)pentan-2-ol
  • ZK 245186
  • Mapracorat (USAN)
  • ZK-245186, BOL-303242X
  • (2R)-1,1,1-Trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-(((2- methylquinolin-5-yl)amino)methyl)pentan-2-ol
  • (2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-[[(2-methyl-5-quinolyl)amino]methyl]pentan-2-ol
  • (2R)-1,1,1-triluoro-4-(5-luoro-2,3-dihydro-1-benzouran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol
  • (R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(((2-methylquinolin-5-yl)amino)methyl)pentan-2-ol
  • 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-gamma,gamma-dimethyl-alpha-(((2-methyl-5- quinolinyl)amino)methyl)-alpha-(trifluoromethyl)-,(alphar)-
  • 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-gamma,gamma-dimethyl-alpha-(((2-methyl-5-quinolinyl)amino)methyl)-alpha-(trifluoromethyl)-, (alphaR)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
462.49 g/molcalc.
Exact mass
462.193 Dacalc.
LogP (octanol/water)
5.69calc.
Topological polar surface area
54.38 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
6calc.
Heavy atoms
33calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(CCCCNc2cccc3ncccc23)c2c(c1)CCO2

c1cc(CCCCNc2cccc3ncccc23)c2c(c1)CCO2

4 rings, 24 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mapracorat suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Mapracorat price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antipsoriatic
  • dermatologic drug
  • ophthalmology drug
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mapracorat is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mapracorat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mapracorat, based on the data on this page

What is Mapracorat?

Mapracorat is an aminoquinoline.

What is the CAS number of Mapracorat?

The CAS registry number of Mapracorat is 887375-26-0.

What is the molecular formula and weight of Mapracorat?

The molecular formula of Mapracorat is C25H26F4N2O2 and its molar mass is 462.49 g/mol.

What is Mapracorat used for?

Known uses and roles of Mapracorat include building blocks in research and laboratory, screening compounds in research and laboratory, antipsoriatic, dermatologic drug, ophthalmology drug and 1 more.

Is Mapracorat hazardous?

Mapracorat carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Mapracorat?

Mapracorat is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mapracorat?

CompoundList lists 2 suppliers of Mapracorat in Canada and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Mapracorat?

Suppliers quote Mapracorat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mapracorat

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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