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Oncology and immunology drugs

Mechlorethamine

Also known as Chlormethine, Nitrogen mustard, Chlorethazine

CAS 51-75-2Formula C5H11Cl2NMolar mass 156.06 g/molEC 200-120-5
Prohibited, not for trade Drug substance
Why it is not for trade
Mechlorethamine chemical structure, C5H11Cl2N, CAS 51-75-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Mobile liquid
Melting point
-60 °C
Boiling point
87 °C
Density
1.118 @ 25 °C/4 °C
Solubility
Very slightly soluble in water, miscible with dimethyl formamide, carbon disulfide, carb…
HS code
292119
Category
Oncology and immunology drugs

What is Mechlorethamine?

Plain description, key identifiers and synonyms

Mechlorethamine is an organochlorine compound and a nitrogen mustard. It has a role as an alkylating agent.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-chloro-N-(2-chloroethyl)-N-methylethanamine
CAS number
51-75-2 CAS number cross-checked
EC number
200-120-5
Molecular formula
C5H11Cl2N
UNII
50D9XSG0VR
InChIKey
HAWPXGHAZFHHAD-UHFFFAOYSA-N
InChI
InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3
SMILES (canonical and isomeric)
CN(CCCl)CCCl

Synonyms

  • Chlormethine
  • Nitrogen mustard
  • Chlorethazine
  • Mustine
  • Mecloretamina
  • Embichin
  • 2-Chloro-N-(2-chloroethyl)-N-methylethanamine
  • Bis(2-chloroethyl)methylamine
  • Dichlor amine
  • Methylbis(2-chloroethyl)amine
  • Clormetina
  • Antimit
  • 2,2'-Dichloro-N-methyldiethylamine
  • N-Methyl-bis(2-chloroethyl)amine
  • N,N-Bis(2-chloroethyl)methylamine
  • Bis(beta-chloroethyl)methylamine
  • Methylbis(beta-chloroethyl)amine
  • Stickstofflost (ebewe)
  • Di(2-chloroethyl)methylamine
  • Methyldi(2-chloroethyl)amine
  • N-Methyl-bis(beta-chloroethyl)amine
  • N,N-Di(chloroethyl)methylamine
  • Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
  • N-Methyl-bis-chloraethylamin
  • beta,beta'-Dichlorodiethyl-N-methylamine
Show all 38 synonyms
  • N-Methyl-2,2'-dichlorodiethylamine
  • TL 146
  • Chloramine (the nitrogen mustard)
  • Diethylamine, 2,2'-dichloro-N-methyl-
  • bis(2-chloroethyl)(methyl)amine
  • Nitrogen mustard (hn 2)
  • Methylchlorethamine
  • Di(chloroethyl)methylamine
  • chloromethine
  • Mechlorethamine N Oxide
  • Nitrogen Mustard N Oxide
  • Methylbis(chloroethylamine)
  • N-Oxide, Nitrogen Mustard

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Mobile liquidexp.
Odour
Faint odor of herringexp.
Melting point
-60 °Cexp.
Boiling point
87 °Cexp.
Density
1.118 @ 25 °C/4 °Cexp.
Solubility
Very slightly soluble in water, miscible with dimethyl formamide, carbon disulfide, carbon tetrachloride, many organic solvents and oilsexp.
Vapour pressure
0.17 mm Hg @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
156.06 g/molcalc.
Exact mass
155.0269 Dacalc.
LogP (octanol/water)
1.4calc.
Topological polar surface area
3.24 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mechlorethamine suppliers

Trading restrictions apply to this substance

Chemical Weapons Convention Schedule 1

Mechlorethamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: OPCW Chemical Weapons Convention Schedule 1

Our policy on controlled substances

Mechlorethamine price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Antineoplastic agent (Hydrochloride).

As a former gas warfare agent.

Lab experiments ... conducted ... for use as cross linking agent in textiles. In USSR ... tested for use in sizing agents for cotton yarn, in grease for metal cutting, as fungicide and as antiviral aerosol disinfectant.

HN-2 is one of three nitrogen mustard blister agents (vesicants). Nitrogen mustards have not previously been used in warfare. The properties of nitrogen mustards are only slightly different from those of sulfur mustards, another major class of blister agents. However, exposure to nitrogen mustards may be more immediately toxic than exposure to sulfur mustard. Nitrogen mustards are alkylating agents that affect DNA and other molecules in the body. Exposure to nitrogen mustard damages the eyes, skin, and respiratory tract and suppresses the immune system.

Read more

Although the nitrogen mustards cause cellular changes within minutes of contact, the onset of pain and other symptoms is delayed. Exposure to large amounts can be fatal. HN-2 has a fruity odor at high concentrations, and a soapy or fishy odor at low concentrations.

Industries and functions

Pharmacological actions

  • Alkylating Agents
  • Antineoplastic Agents, Alkylating
  • Chemical Warfare Agents
  • Irritants

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • genotoxin
  • mutagen
  • pharmaceutical

Pharmacology

Mechlorethamine is an Alkylating Drug. The mechanism of action of mechlorethamine is as an Alkylating Activity.

How it is made

A nitrogen mustard prepared by action of thionyl chloride on 2,2'-(methylimino)diethanol in trichloroethylene.

Regulatory status

Inventories, regulations and trade controls that list this substance

Chemical Weapons Convention Schedule 1

Mechlorethamine is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: OPCW Chemical Weapons Convention Schedule 1

Our policy on controlled substances

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Chlormethine (INN) and its salts, Ref no: 87, Annex ref: II/87
  • Active ingredient in FDA approved drug labels

Controls

  • Chemical Weapons Convention Schedule 1

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mechlorethamine is traded under.

HS 2921.19Indicative HS code

Acyclic monoamines and their derivatives, salts thereof, other

World exports in 2024
$1.21B
+4.0% vs 2023, imports $1.16B
2019 to 2024
Top exporters
  1. China35.5%
  2. United States17.9%
  3. Germany16.4%
Top importers
  1. United States14.1%
  2. South Korea9.7%
  3. Japan8.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Mechlorethamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mechlorethamine, based on the data on this page

What is Mechlorethamine?

Mechlorethamine is an organochlorine compound and a nitrogen mustard. It has a role as an alkylating agent.

What is the CAS number of Mechlorethamine?

The CAS registry number of Mechlorethamine is 51-75-2.

What is the molecular formula and weight of Mechlorethamine?

The molecular formula of Mechlorethamine is C5H11Cl2N and its molar mass is 156.06 g/mol.

What is Mechlorethamine used for?

Antineoplastic agent (Hydrochloride). As a former gas warfare agent. Lab experiments ... conducted ... for use as cross linking agent in textiles. In USSR ... tested for use in sizing agents for cotton yarn, in grease for metal cutting, as fungicide and as antiviral aerosol disinfectant.

Is Mechlorethamine hazardous?

No GHS hazard classification for Mechlorethamine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mechlorethamine?

Mechlorethamine is usually classified under HS code 292119 (Acyclic monoamines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Can I buy Mechlorethamine on CompoundList?

No. Mechlorethamine is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Mechlorethamine

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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