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Hormones and steroids

Medroxyprogesterone acetate

Also known as Medroxyprogesterone 17-acetate, Provera, Depo-Provera

CAS 71-58-9Formula C24H34O4Molar mass 386.53 g/molEC 200-757-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 106 suppliers listed Drug substance
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Medroxyprogesterone acetate chemical structure, C24H34O4, CAS 71-58-9
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
207.2 to 208.9
Solubility
Less than 1 mg/mL at 73 °F
HS code
293723
Category
Hormones and steroids
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Medroxyprogesterone acetate?

Plain description, key identifiers and synonyms

Medroxyprogesterone acetate is an acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control. It has a role as an antioxidant, an inhibitor, an antineoplastic agent, a female contraceptive drug, a synthetic oral contraceptive, an androgen, a progestin and an adjuvant. It is a 20-oxo steroid, an acetate ester, a steroid ester, a 3-oxo-Delta(4) steroid and a corticosteroid. It is functionally related to a medroxyprogesterone.

Medroxyprogesterone acetate is an injectible form of birth control.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
CAS number
71-58-9 CAS number cross-checkedOther or deprecated CAS: 1301724-98-0
EC number
200-757-9
Molecular formula
C24H34O4
UNII
C2QI4IOI2G
MDL number
MFCD00010483
InChIKey
PSGAAPLEWMOORI-PEINSRQWSA-N
InChI
InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
Canonical SMILES
CC(=O)OC1(C(C)=O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C
Isomeric SMILES
C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C

Synonyms

  • Medroxyprogesterone 17-acetate
  • Provera
  • Depo-Provera
  • Metigestrona
  • Farlutin
  • Clinovir
  • Gestapuran
  • Lutopolar
  • Perlutex
  • Oragest
  • Veramix
  • Amen
  • Methylacetoxyprogesterone
  • Medroxyacetate progesterone
  • Progestalfa
  • Clinofem
  • Nadigest
  • Nidaxin
  • Prodasone
  • Progevera
  • Proverone
  • Repromix
  • Sirprogen
  • Hysron
  • Depo-clinovir
Show all 39 synonyms
  • Depo-progestin
  • Depot-medroxyprogesterone acetate
  • Repromap
  • Provera dosepak
  • Depo-Progevera
  • 6-alpha-Methyl-17-alpha-acetoxyprogesterone
  • Cycrin
  • MAP (steroid)
  • Depo-Subq Provera 104
  • 6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate
  • Aragest
  • Farlutal
  • 17alpha-Hydroxy-6alpha-methylprogesterone acetate
  • 6alpha-Methyl-17alpha-hydroxyprogesterone acetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
207.2 to 208.9exp.
Solubility
Less than 1 mg/mL at 73 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
386.53 g/molcalc.
Exact mass
386.2457 Dacalc.
LogP (octanol/water)
4.66calc.
Topological polar surface area
60.44 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.79calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CCC3C2CC1

O=C1C=C2CCC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

1,419 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (19)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Medroxyprogesterone acetate suppliers

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All 106 suppliers
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Where suppliers are based

106 suppliers in 17 countries

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Medroxyprogesterone acetate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antineoplastic Agents, Hormonal
  • Contraceptive Agents, Female
  • Contraceptive Agents, Hormonal
  • Contraceptive Agents, Male

Roles

  • adjuvant
  • agonist
  • analgesic
  • androgen
  • anti-HIV agent
  • anticoagulant
  • antihypertensive agent
  • antimicrobial agent
  • antineoplastic agent
  • antioxidant
  • antiviral agent
  • bone density conservation agent
  • cardiovascular drug
  • contraceptive drug
  • female contraceptive drug
  • hematologic agent
  • hypoglycemic agent
  • inhibitor
  • molecular messenger
  • oral contraceptive
  • pharmaceutical
  • progestin
  • reproductive control drug
  • synthetic oral contraceptive

Pharmacology

Medroxyprogesterone Acetate is a synthetic, acetate derivative of the sex hormone progesterone. Medroxyprogesterone 17-acetate (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Medroxyprogesterone acetate is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Medroxyprogesterone acetate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Medroxyprogesterone acetate, based on the data on this page

What is Medroxyprogesterone acetate?

Medroxyprogesterone acetate is an acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.

What is the CAS number of Medroxyprogesterone acetate?

The CAS registry number of Medroxyprogesterone acetate is 71-58-9. Other or deprecated CAS numbers: 1301724-98-0.

What is the molecular formula and weight of Medroxyprogesterone acetate?

The molecular formula of Medroxyprogesterone acetate is C24H34O4 and its molar mass is 386.53 g/mol.

What is Medroxyprogesterone acetate used for?

Use classes: Pharmaceuticals.

Is Medroxyprogesterone acetate hazardous?

Medroxyprogesterone acetate carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Medroxyprogesterone acetate?

Medroxyprogesterone acetate is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Medroxyprogesterone acetate?

CompoundList lists 106 suppliers of Medroxyprogesterone acetate in China, United States, United Kingdom, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Medroxyprogesterone acetate in India?

4 suppliers in India list Medroxyprogesterone acetate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Medroxyprogesterone acetate?

Suppliers quote Medroxyprogesterone acetate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Medroxyprogesterone acetate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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