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Hormones and steroids

Megestrol

Also known as Megestrolo, Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, Chronopil

CAS 3562-63-8Formula C22H30O3Molar mass 342.48 g/molEC 222-628-6
GHS signal word: Warning. Pictograms: Serious health hazard 48 suppliers listed Drug substance
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Megestrol chemical structure, C22H30O3, CAS 3562-63-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3562-63-8
Formula
C22H30O3
Molar mass
342.48 g/mol
Solubility
WHITE OR ALMOST WHITE, CRYSTALLINE POWDER, SPARINGLY SOL IN ALC, SLIGHTLY SOL IN ETHER &…
HS code
293723
Category
Hormones and steroids

What is Megestrol?

Plain description, key identifiers and synonyms

Megestrol is a 3-oxo 4-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. It has a role as an antineoplastic agent, a contraceptive drug, a synthetic oral contraceptive, an appetite enhancer and a progestin. It is a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy steroid, a 20-oxo steroid and a 3-oxo-Delta(4) steroid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
CAS number
3562-63-8 CAS number cross-checked
EC number
222-628-6
Molecular formula
C22H30O3
UNII
EA6LD1M70M
InChIKey
VXIMPSPISRVBPZ-NWUMPJBXSA-N
InChI
InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1
Canonical SMILES
CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C
Isomeric SMILES
CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)O)C)[C@@]4(C1=CC(=O)CC4)C

Synonyms

  • Megestrolo
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
  • Chronopil
  • Megestrolum
  • (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
  • (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta(a)phenanthren-3-one
  • Compound 5071
  • 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
  • Megestrol Acetate EP Impurity B
  • (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
  • Megestrol (INN)
  • Megestrol (Acetate)
  • Chronopil (TN)
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione, Megestrol, 6-Methyl-17-hydroxypregna-4,6-diene-3,20-dione
  • Megestrol (Standard)
  • Megestrol Solution in Acetonitrile, 100ug/mL
  • Megestrol Solution in Acetonitrile, 1000ug/mL
  • Megestrol acetate impurity b

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Odour
Odorlessexp.
Taste
Tastelessexp.
Solubility
WHITE OR ALMOST WHITE, CRYSTALLINE POWDER, SPARINGLY SOL IN ALC, SLIGHTLY SOL IN ETHER & FIXED OILS, SOL IN ACETONE, VERY SOL IN CHLOROFORM /ACETATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
342.48 g/molcalc.
Exact mass
342.2195 Dacalc.
LogP (octanol/water)
4calc.
Topological polar surface area
54.37 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2C=CC3C4CCCC4CCC3C2CC1

O=C1C=C2C=CC3C4CCCC4CCC3C2CC1

4 rings, 18 atoms.

106 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Megestrol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 48 suppliers
30 of 30 offers
  • Xianju Belter Co., Ltd
    China ManufacturerUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • 001Chemical
    China, HangzhouUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
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  • A2B Chem LLC
    United States, San DiegoUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
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  • Aa Blocks LLC
    United States, San DiegoUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • Accel Scientific S.L.
    Spain, BarcelonaUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • Achemtek
    United States, WoburnUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View
  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    MegestrolGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

48 suppliers in 11 countries

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Megestrol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Pharmacological actions

  • Antineoplastic Agents, Hormonal
  • Contraceptives, Oral, Hormonal
  • Contraceptives, Oral, Synthetic

Roles

  • agonist
  • antineoplastic agent
  • appetite enhancer
  • appetite regulator
  • contraceptive drug
  • female contraceptive drug
  • hormone
  • molecular messenger
  • oral contraceptive
  • pharmaceutical
  • progestin
  • progestogen
  • reproductive control drug
  • sex hormone
  • synthetic oral contraceptive

Pharmacology

Megestrol is a Progestin.

How it is made

Prepared by oxidation of 17alpha-acetoxy-3beta-hydroxy-6-methylpregn-5-en-20-one with aluminium tert-butoxide and para-quinone in dry benzene. (Megestrol acetate)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Megestrol is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Megestrol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Megestrol, based on the data on this page

What is Megestrol?

Megestrol is a 3-oxo 4-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. It has a role as an antineoplastic agent, a contraceptive drug, a synthetic oral contraceptive, an appetite enhancer and a progestin.

What is the CAS number of Megestrol?

The CAS registry number of Megestrol is 3562-63-8.

What is the molecular formula and weight of Megestrol?

The molecular formula of Megestrol is C22H30O3 and its molar mass is 342.48 g/mol.

What is Megestrol used for?

Veterinary medication:.

Is Megestrol hazardous?

Megestrol carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility. suspected of damaging the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Megestrol?

Megestrol is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Megestrol?

CompoundList lists 48 suppliers of Megestrol in United States, China, United Kingdom, Spain and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Megestrol?

Suppliers quote Megestrol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Megestrol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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