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Central nervous system drugs

Memantine

Also known as 3,5-dimethyladamantan-1-amine, 1-Amino-3,5-dimethyladamantane, Memantina

CAS 19982-08-2Formula C12H21NMolar mass 179.31 g/molEC 690-724-9
GHS signal word: Warning. Pictograms: Harmful or irritant 77 suppliers listed Drug substance
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Memantine chemical structure, C12H21N, CAS 19982-08-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
19982-08-2
Formula
C12H21N
Appearance
Oil
Melting point
290 to 295
HS code
292130
Category
Central nervous system drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Memantine?

Plain description, key identifiers and synonyms

Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel), NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as an antidepressant, an antiparkinson drug, a dopaminergic agent, a NMDA receptor antagonist and a neuroprotective agent. It is a primary aliphatic amine and a member of adamantanes. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3,5-dimethyladamantan-1-amine
CAS number
19982-08-2 CAS number cross-checked
EC number
690-724-9
Molecular formula
C12H21N
UNII
W8O17SJF3T
MDL number
MFCD02114015
InChIKey
BUGYDGFZZOZRHP-UHFFFAOYSA-N
InChI
InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
SMILES (canonical and isomeric)
CC12CC3CC(C1)(CC(C3)(C2)N)C

Synonyms

  • 3,5-dimethyladamantan-1-amine
  • 1-Amino-3,5-dimethyladamantane
  • Memantina
  • 3,5-Dimethyl-1-adamantanamine
  • Memantinum
  • 1,3-Dimethyl-5-adamantanamine
  • nemdatine
  • 3,5-Dimethyl-1-aminoadamantane
  • Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-
  • 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
  • 1,3-Dimethyl-5-aminoadamantane
  • Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl-
  • Memantin
  • Axura
  • 3,5-Dimethyl-1-adamantylamine
  • 3,5-dimethyladamantanylamine
  • Memantine (INN)
  • alzantin
  • 3,5-dimethyltricyclo[3.3.1.1~3,7~]decan-1-amine
  • DMAA [Antiparkinson Agent]
  • DRG 0267
  • Exiba (TN)
  • Biomol-NT_000209
  • DivK1c_000068
  • 1-amino-3,5-dimethyladamantan

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oilexp.
Melting point
290 to 295exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
179.31 g/molcalc.
Exact mass
179.1674 Dacalc.
LogP (octanol/water)
2.69calc.
Topological polar surface area
26.02 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
13calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1C2CC3CC1CC(C2)C3

C1C2CC3CC1CC(C2)C3

4 rings, 10 atoms, the Adamantane ring system.

2,136 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Memantine suppliers

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All 77 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

77 suppliers in 20 countries

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Memantine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Antiparkinson Agents, Dopamine Agents, Excitatory Amino Acid Antagonists.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antiparkinson Agents
  • Dopamine Agents
  • Excitatory Amino Acid Antagonists

Roles

  • NMDA receptor antagonist
  • analgesic
  • antagonist
  • anti-obesity agent
  • antidepressant
  • antidyskinesia agent
  • antiglaucoma drug
  • antineoplastic agent
  • antiparkinson drug
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • excitatory amino acid antagonist
  • immunomodulator
  • immunosuppressive agent
  • neuroprotective agent
  • neurotransmitter agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Memantine is a N-methyl-D-aspartate Receptor Antagonist. The mechanism of action of memantine is as a NMDA Receptor Antagonist.

How it is made

/Preparation/ of the free base and hydrochloride: J. Mills, E. Krumkalns, USA 3391142 (1968 to Lilly).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Memantine is traded under.

HS 2921.30Indicative HS code

Cyclanic, cyclenic or cycloterpenic mono- or polyamines, and their derivatives, salts…

World exports in 2024
$643M
−7.5% vs 2023, imports $610M
2019 to 2024
Top exporters
  1. China42.9%
  2. Germany19.9%
  3. Belgium8.9%
Top importers
  1. Germany12.7%
  2. United States9.6%
  3. China8.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Memantine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Memantine, based on the data on this page

What is Memantine?

Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel), NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.

What is the CAS number of Memantine?

The CAS registry number of Memantine is 19982-08-2.

What is the molecular formula and weight of Memantine?

The molecular formula of Memantine is C12H21N and its molar mass is 179.31 g/mol.

What is Memantine used for?

Veterinary medication:. Antiparkinson Agents, Dopamine Agents, Excitatory Amino Acid Antagonists. Use classes: Pharmaceuticals.

Is Memantine hazardous?

Memantine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Memantine?

Memantine is usually classified under HS code 292130 (Cyclanic, cyclenic or cycloterpenic mono- or polyamines, and their derivatives, salts…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Memantine?

CompoundList lists 77 suppliers of Memantine in China, United States, India, Germany and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Memantine in India?

6 suppliers in India list Memantine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Memantine?

Suppliers quote Memantine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Memantine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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