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Pharmaceuticals and APIs

Metaxalone

Also known as Skelaxin, Zorane, Methaxalonum

CAS 1665-48-1Formula C12H15NO3Molar mass 221.26 g/molEC 216-777-6
GHS signal word: Warning. Pictograms: Harmful or irritant 68 suppliers listed Drug substance
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Metaxalone chemical structure, C12H15NO3, CAS 1665-48-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to almost white crystalline powder
Melting point
122 °C
Boiling point
223 °C
Solubility
Practically insoluble in water
HS code
293499
Category
Pharmaceuticals and APIs
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Metaxalone?

Plain description, key identifiers and synonyms

Metaxalone is an aromatic ether.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
CAS number
1665-48-1 CAS number cross-checked
EC number
216-777-6
Molecular formula
C12H15NO3
UNII
1NMA9J598Y
MDL number
MFCD00867700
InChIKey
IMWZZHHPURKASS-UHFFFAOYSA-N
InChI
InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
SMILES (canonical and isomeric)
CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C

Synonyms

  • Skelaxin
  • Zorane
  • Methaxalonum
  • Metaxalon
  • Methoxolone
  • 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
  • 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
  • Metaxalona
  • Metassalone
  • Metaxalonum
  • Flexura
  • 5-(3,5-Xyloloxymethyl)oxazolidin-2-one
  • CL 39,148
  • 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
  • 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
  • 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
  • 5-((3,5-Xylyloxy)methyl)-2-oxazolidinone
  • 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-
  • 5-(3,5-dimethylphenoxymethyl)-1,3-oxazolidin-2-one
  • 2-Oxazolidinone, 5-[(3,5-xylyloxy)methyl]-
  • 5-[(3,5-Dimethylphenoxy)methyl]-2-oxazolidinone
  • 5-((3,5-Dimethylphenoxy)methyl)-1,3-oxazolidin-2-one
  • Metaxal
  • metaxalone tablet
  • 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Show all 31 synonyms
  • Metaxolone
  • Metazalone
  • Metazolone
  • 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one
  • AHR 438
  • 5-(3,5-dimethylphenoxymethyl)-2-oxazolidinone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to almost white crystalline powderexp.
Odour
Odorlessexp.
Melting point
122 °Cexp.
Boiling point
223 °Cexp.
Solubility
Practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
221.26 g/molcalc.
Exact mass
221.1052 Dacalc.
LogP (octanol/water)
1.79calc.
Topological polar surface area
47.56 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NCC(COc2ccccc2)O1

O=C1NCC(COc2ccccc2)O1

2 rings, 14 atoms, the 5-(Phenoxymethyl)-1,3-oxazolidin-2-one ring system.

36 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Metaxalone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 68 suppliers
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Where suppliers are based

68 suppliers in 10 countries

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Metaxalone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Neuromuscular Agents

Pharmacology

Metaxalone is a Muscle Relaxant. The physiologic effect of metaxalone is by means of Centrally-mediated Muscle Relaxation.

How it is made

Lunsford et al, j am chem soc 82, 1166 (1960), lunsford, us pat 3,062,827 (1962 to ah robins).

Prepared by heating urea and 3-(3',5'-dimethylphenoxy)-1,2-propanediol to 200 °C

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Metaxalone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Metaxalone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Metaxalone, based on the data on this page

What is Metaxalone?

Metaxalone is an aromatic ether.

What is the CAS number of Metaxalone?

The CAS registry number of Metaxalone is 1665-48-1.

What is the molecular formula and weight of Metaxalone?

The molecular formula of Metaxalone is C12H15NO3 and its molar mass is 221.26 g/mol.

What is Metaxalone used for?

Use classes: Pharmaceuticals.

Is Metaxalone hazardous?

Metaxalone carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Metaxalone?

Metaxalone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Metaxalone?

CompoundList lists 68 suppliers of Metaxalone in India, China, United States, Germany and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Metaxalone in India?

20 suppliers in India list Metaxalone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Metaxalone?

Suppliers quote Metaxalone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Metaxalone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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