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Analgesics and anti-inflammatories

Methotrexate safety data

GHS hazards, precautions, first aid, handling and transport for Methotrexate. A classification summary, not a safety data sheet.
CAS 59-05-2Formula C20H22N8O5

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

GHS classification

Pictograms, signal word and hazard classes of the GHS classification

GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
Signal word
Danger

Hazard classes and categories

  • Acute Tox. 3 (oral)
  • Skin Irrit. 2
  • Eye Irrit. 2
  • Muta. 1A/1B
  • Repr. 1A/1B

Hazard statements

H codes grouped by type. Percentages show the share of classification notifications that report the statement

Health hazards

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H340May cause genetic defects.
  • H360May damage fertility or the unborn child.

Precautionary statements

P codes for prevention, response, storage and disposal

Prevention

  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.

Response

  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

Storage

  • P405Store locked up.

Disposal

  • P501Dispose of contents and container in accordance with local regulations.

First aid

General first aid measures. Get medical advice if you feel unwell

If inhaled
IMMEDIATELY leave the contaminated area, take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used, if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
Skin contact
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eye contact
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
If swallowed
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

Handling, storage and disposal

Summaries only, follow the supplier SDS for your grade

Safe handling

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Storage

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 °C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 °C. /Methotrexate sodium/

Exposure limits and toxicity

Occupational exposure limits and toxicity data

SYMPTOMS: Symptoms of exposure to this compound include renal damage, leukopenia, headache, drowsiness, blurred vision, aphasia and hemiparesis. In addition, it causes developmental abnormalities of the craniofacial area and the musculoskeletal system, carcinogenic effects, leukemia, lymphoma effects including Hodgkin's disease, thrombocytopenia, bone marrow changes, other blood changes, cerebral spinal fluid effects, eye effects, blood pressure lowering, cough, dyspnea, fibrosis (pneumoconiosis), cyanosis, gastrointestinal effects, fatty liver degeneration and other liver changes, hepatitis, impaired liver function tests, skin tumors, fever, effects on inflammation or mediation of…

Transport information

UN dangerous goods classification for road, sea and air

UN number
UN 3249

Shipping rules depend on mode, quantity and packaging. Confirm the classification with the supplier SDS and your freight forwarder.

Supplier safety data sheets

SDS documents uploaded by suppliers who list this chemical

No supplier has uploaded an SDS for Methotrexate yet. Suppliers usually send one with their quote. Request quotes

Safety questions

Quick answers about handling Methotrexate safely

Is Methotrexate hazardous?

Methotrexate carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

Which GHS pictograms apply to Methotrexate?

The GHS classification of Methotrexate shows 3 pictograms: GHS06 (acute toxicity (severe)), GHS07 (harmful or irritant), GHS08 (serious health hazard).

What is the UN number of Methotrexate?

Methotrexate is transported under UN 3249. Check the supplier SDS and the current ADR, IMDG or IATA rules before shipping.

How should Methotrexate be stored?

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 °C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 °C. /Methotrexate sodium/

Where can I get the SDS for Methotrexate?

Ask the supplier for the safety data sheet of the exact grade you buy. Suppliers on CompoundList can attach their SDS to listings and send it with a quote. This page is a GHS classification summary, not an SDS.

GHS classification summary, not an SDS. Always check the supplier's SDS. Last updated 7 Oct 2026. Report an error

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