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Pharmaceuticals and APIs

Methscopolamine bromide

Also known as scopolamine methyl bromide, Holopon, Hyoscine Methobromide

CAS 155-41-9Formula C18H24BrNO4Molar mass 398.30 g/molEC 205-844-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 62 suppliers listed Drug substance
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Methscopolamine bromide chemical structure, C18H24BrNO4, CAS 155-41-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
155-41-9
Formula
C18H24BrNO4
Molar mass
398.30 g/mol
EC number
205-844-5
HS code
293399
Category
Pharmaceuticals and APIs

What is Methscopolamine bromide?

Plain description, key identifiers and synonyms

Scopolamine methobromide is a quaternary ammonium salt resulting from the reaction of the amino group of scopolamine with methyl bromide. It has a role as a muscarinic antagonist, a parasympatholytic, an antiemetic and an antispasmodic drug. It is a bromide salt and a quaternary ammonium salt. It is functionally related to a scopolamine.

Methscopolamine bromide is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(1R,2R,4S,5S)-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate bromide
CAS number
155-41-9 CAS number cross-checked
EC number
205-844-5
Molecular formula
C18H24BrNO4
UNII
RTN51LK7WL
MDL number
MFCD00078560
InChIKey
CXYRUNPLKGGUJF-OZVSTBQFSA-M
InChI
InChI=1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12?,13-,14-,15+,16-,17+;/m1./s1
Canonical SMILES
C[N+]1(C)C2CC(OC(=O)C(CO)c3ccccc3)CC1C1OC12.[Br-]
Isomeric SMILES
C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4)C.[Br-]

Synonyms

  • scopolamine methyl bromide
  • Holopon
  • Hyoscine Methobromide
  • (-)-scopolamine methobromide
  • (-)-Scopolamine methyl bromide
  • Methscopolamine (bromide)
  • Scopolamine methobromide
  • Hyoscine methyl bromide
  • Methylscopolamine bromide
  • N-Methylhyoscinium bromide
  • Proscomide
  • N-Methylscopolamine Bromide
  • N-Methylhyoscine bromide
  • N-Methylscopolammonium bromide
  • Ampyrox
  • Mescopil
  • Paraspan
  • Restropin
  • Blocan
  • Diopal
  • Nutrop
  • Scopolamine methylbromide
  • Neo-Avagal
  • Lescopine bromide
  • (S)-6beta,7beta-Epoxy-8-methyl-3alpha-(-)-tropoyloxy-1alphaH,5alphaH-tromanium bromide
Show all 38 synonyms
  • Epoxymethamine bromide
  • Hyoscine methylbromide
  • (1R,2R,4S,5S,7s)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
  • Methoscopylamine bromide
  • (-)-Scopolamine methyl bromide, Hyoscine methyl bromide
  • Scordin
  • Pamine Forte
  • Methylscopolamine hydrobromide
  • Hyoscin methobromide
  • Epoxytropine tropate methylbromide
  • Hyoscin-N-methylbromid
  • Scopolammonium, N-methylbromide
  • Scopolamin-N-methylbromid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
398.30 g/molcalc.
Exact mass
397.0889 Dacalc.
LogP (octanol/water)
-1.93calc.
Topological polar surface area
59.06 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
6calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Cc1ccccc1)OC1CC2NC(C1)C1OC21

O=C(Cc1ccccc1)OC1CC2NC(C1)C1OC21

4 rings, 19 atoms.

88 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H400Very toxic to aquatic life.
Precautionary statements (11)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methscopolamine bromide suppliers

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Where suppliers are based

62 suppliers in 15 countries

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Methscopolamine bromide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antiemetic
  • antispasmodic drug
  • cholinergic antagonist
  • cholinergic drug
  • muscarinic antagonist
  • muscle relaxant
  • neuromuscular agent
  • neurotransmitter agent
  • parasympatholytic
  • pharmaceutical

Pharmacology

Methscopolamine Bromide is the bromide salt form of methscopolamine, a quaternary ammonium derivative of scopolamine with anticholinergic properties. Methscopolamine bromide exerts its effect on muscarine receptors in the gastrointestinal tract, thereby blocking the actions of acetylcholine. This leads to an inhibition of gastric secretions and gastrointestinal motility.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methscopolamine bromide is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methscopolamine bromide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methscopolamine bromide, based on the data on this page

What is Methscopolamine bromide?

Scopolamine methobromide is a quaternary ammonium salt resulting from the reaction of the amino group of scopolamine with methyl bromide. It has a role as a muscarinic antagonist, a parasympatholytic, an antiemetic and an antispasmodic drug. It is a bromide salt and a quaternary ammonium salt.

What is the CAS number of Methscopolamine bromide?

The CAS registry number of Methscopolamine bromide is 155-41-9.

What is the molecular formula and weight of Methscopolamine bromide?

The molecular formula of Methscopolamine bromide is C18H24BrNO4 and its molar mass is 398.30 g/mol.

What is Methscopolamine bromide used for?

Known uses and roles of Methscopolamine bromide include antiemetic, antispasmodic drug, cholinergic antagonist, cholinergic drug, muscarinic antagonist and 5 more.

Is Methscopolamine bromide hazardous?

Methscopolamine bromide carries the GHS signal word "Warning". Main hazards: harmful in contact with skin, harmful if inhaled, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methscopolamine bromide?

Methscopolamine bromide is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methscopolamine bromide?

CompoundList lists 62 suppliers of Methscopolamine bromide in United States, China, Germany, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methscopolamine bromide in India?

3 suppliers in India list Methscopolamine bromide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methscopolamine bromide?

Suppliers quote Methscopolamine bromide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methscopolamine bromide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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