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Heterocyclic building blocks

N-Nitrosopiperidine

Also known as 1-Nitrosopiperidine, Piperidine, 1-nitroso-, NO-Pip

CAS 100-75-4Formula C5H10N2OMolar mass 114.15 g/molEC 202-886-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 8 suppliers listed
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N-Nitrosopiperidine chemical structure, C5H10N2O, CAS 100-75-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow oil
Boiling point
219 °C
Density
1.0631 g/cm³ at 18.5 °C
Solubility
Soluble in water (7.7%) and in organic solvents and lipids
HS code
293339
Category
Heterocyclic building blocks
UN number
UN 2811
Illustrative photo, golden oil with amber dropper bottles on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is N-Nitrosopiperidine?

Plain description, key identifiers and synonyms

N-nitrosopiperidine is a nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. It has a role as a mutagen, a carcinogenic agent, an apoptosis inducer and an environmental contaminant. It is a piperidine and a nitrosamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-nitrosopiperidine
CAS number
100-75-4 CAS number cross-checked
EC number
202-886-6
Molecular formula
C5H10N2O
UNII
6N066XUL4L
InChIKey
UWSDONTXWQOZFN-UHFFFAOYSA-N
InChI
InChI=1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2
SMILES (canonical and isomeric)
C1CCN(CC1)N=O

Synonyms

  • 1-Nitrosopiperidine
  • Piperidine, 1-nitroso-
  • NO-Pip
  • NPIP
  • Nitrosopiperidin
  • N-Nitroso-piperidin
  • nitrosopiperidine
  • N-N-Pip
  • N-PIP
  • TL 266
  • N-nitrosopentamethyleneimine
  • Hexahydro-N-nitroso-pyridine
  • RCRA waste number U179
  • Pyridine, hexahydro-N-nitroso-
  • 1-Nitroso-piperidine
  • RCRA waste no. U179
  • Piperidine, 1-nitroso-, 1-Nitrosopiperidine, N-Nitrosopiperidine, NPI, NPIP, NSC 138
  • N-nitrosohexahydropyridine
  • Nitrosopiperidine, n-
  • 5-20-03-00530 (Beilstein Handbook Reference)
  • N-Nitrosopiperidine 10 microg/mL in Methanol
  • 1-Nitrosopiperidine-d4, NPI-d4, NPIP-d4, NSC 138-d4,

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow oilexp.
Boiling point
219 °Cexp.
Density
1.0631 g/cm³ at 18.5 °Cexp.
Solubility
Soluble in water (7.7%) and in organic solvents and lipidsexp.
Vapour pressure
9.20 × 10⁻² mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
114.15 g/molcalc.
Exact mass
114.0793 Dacalc.
LogP (octanol/water)
1.15calc.
Topological polar surface area
32.67 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCNCC1

C1CCNCC1

1 ring, 6 atoms, the Piperidine ring system.

32,085 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H351Suspected of causing cancer.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

N-Nitrosopiperidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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Where suppliers are based

8 suppliers in 5 countries

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N-Nitrosopiperidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

N-Nitroso compounds are produced primarily as research chemicals and not for commercial purposes. (N-Nitroso compounds).

Pharmacological actions

  • Carcinogens
  • Mutagens

Roles

  • aetiopathogenetic role
  • apoptosis inducer
  • carcinogenic agent
  • environmental contaminant
  • genotoxin
  • mutagen

Pharmacology

N-Nitrosopiperidine is a clear, yellow, oily, liquid that is light sensitive and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosopiperidine is used in laboratory research to induce tumors in experimental animals. This substance is naturally formed in foods that contain sodium nitrite as a preservative, including meat, fish and cheese, as a result of nitrosation of piperidine in the presence of nitrite. N-Nitrosopiperidine is reasonably anticipated to be a human carcinogen. (NCI05)

How it is made

The reaction of piperidine with nitrogen dioxide or nitric oxide under pressure and in the presence of suitable catalysts

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code N-Nitrosopiperidine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for N-Nitrosopiperidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about N-Nitrosopiperidine, based on the data on this page

What is N-Nitrosopiperidine?

N-nitrosopiperidine is a nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.

What is the CAS number of N-Nitrosopiperidine?

The CAS registry number of N-Nitrosopiperidine is 100-75-4.

What is the molecular formula and weight of N-Nitrosopiperidine?

The molecular formula of N-Nitrosopiperidine is C5H10N2O and its molar mass is 114.15 g/mol.

What is N-Nitrosopiperidine used for?

N-Nitroso compounds are produced primarily as research chemicals and not for commercial purposes. (N-Nitroso compounds).

Is N-Nitrosopiperidine hazardous?

N-Nitrosopiperidine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of N-Nitrosopiperidine?

N-Nitrosopiperidine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy N-Nitrosopiperidine?

CompoundList lists 8 suppliers of N-Nitrosopiperidine in China, India, Czech Republic, Singapore and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy N-Nitrosopiperidine in India?

2 suppliers in India list N-Nitrosopiperidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of N-Nitrosopiperidine?

Suppliers quote N-Nitrosopiperidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle N-Nitrosopiperidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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