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Impurities and reference standards

N4-Hydroxycytidine

Also known as N(4)-Hydroxycytidine, EIDD-1931, Uridine, 4-oxime

CAS 3258-02-4Formula C9H13N3O6Molar mass 259.22 g/molEC 868-922-3
GHS signal word: Warning. Pictograms: Harmful or irritant 11 suppliers listed
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N4-Hydroxycytidine chemical structure, C9H13N3O6, CAS 3258-02-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3258-02-4
Formula
C9H13N3O6
Molar mass
259.22 g/mol
EC number
868-922-3
HS code
293499
Category
Impurities and reference standards

What is N4-Hydroxycytidine?

Plain description, key identifiers and synonyms

N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N4-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. It has a role as an anticoronaviral agent, an antiviral agent, a drug metabolite and a human xenobiotic metabolite. It is a ketoxime and a nucleoside analogue. It is functionally related to a cytidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
CAS number
3258-02-4 CAS number cross-checked
EC number
868-922-3
Molecular formula
C9H13N3O6
UNII
C3D11PV2O4
MDL number
MFCD01675695
InChIKey
XCUAIINAJCDIPM-XVFCMESISA-N
InChI
InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1
Canonical SMILES
O=c1nc(NO)ccn1C1OC(CO)C(O)C1O
Isomeric SMILES
C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Synonyms

  • N(4)-Hydroxycytidine
  • EIDD-1931
  • Uridine, 4-oxime
  • 4-oxime uridine
  • 4-N-Hydroxycytidine
  • EiDD1931
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)-1,2-dihydropyrimidin-2-one
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-4-(hydroxyamino)-1,2-dihydropyrimidin-2-one
  • N-hydroxycytidine
  • Beta-D-N4-hydroxycytidine
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • EIDD 1931
  • Molnupiravir Impurity 1
  • (E)-1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyamino)pyrimidin-2(1H)-one
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyamino)pyrimidin-2-one
  • N-4-Hydroxycytidine
  • Cytidine, N-hydroxy-
  • 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyamino)pyrimidin-2(1H)-one
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • Molnupiravir IP Impurity L
  • beta-D-N(4)-hydroxycytidine
  • N-hydroxy-3,4-dihydrocytidine
  • EIDD 1931 - Bio-X trade mark
Show all 30 synonyms
  • EIDD-1931, NHC, beta-D-N4-hydroxycytidine
  • (E)-1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furyl]-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxyamino-1H-pyrimidin-2-one
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyimino)-1,2,3,4-tetrahydropyrimidin-2-one
  • Su

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
259.22 g/molcalc.
Exact mass
259.0804 Dacalc.
LogP (octanol/water)
-2.34calc.
Topological polar surface area
137.1 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
3calc.
Heavy atoms
18calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1ncccn1C1CCCO1

O=c1ncccn1C1CCCO1

2 rings, 12 atoms.

1,589 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

N4-Hydroxycytidine suppliers

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Where suppliers are based

11 suppliers in 3 countries

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N4-Hydroxycytidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • animal metabolite
  • anticoronaviral agent
  • antimicrobial agent
  • antiviral agent
  • drug metabolite
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • xenobiotic metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code N4-Hydroxycytidine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for N4-Hydroxycytidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about N4-Hydroxycytidine, based on the data on this page

What is N4-Hydroxycytidine?

N(4)-hydroxycytidine is a nucleoside analogue that is cytidine which carries a hydroxy group at the N4-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV.

What is the CAS number of N4-Hydroxycytidine?

The CAS registry number of N4-Hydroxycytidine is 3258-02-4.

What is the molecular formula and weight of N4-Hydroxycytidine?

The molecular formula of N4-Hydroxycytidine is C9H13N3O6 and its molar mass is 259.22 g/mol.

What is N4-Hydroxycytidine used for?

Known uses and roles of N4-Hydroxycytidine include animal metabolite, anticoronaviral agent, antimicrobial agent, antiviral agent, drug metabolite and 6 more.

Is N4-Hydroxycytidine hazardous?

N4-Hydroxycytidine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of N4-Hydroxycytidine?

N4-Hydroxycytidine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy N4-Hydroxycytidine?

CompoundList lists 11 suppliers of N4-Hydroxycytidine in China, United States and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of N4-Hydroxycytidine?

Suppliers quote N4-Hydroxycytidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle N4-Hydroxycytidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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