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Nucleosides and nucleotides

Naadp+

Also known as beta-NAADP, nicotinic acid-adenine dinucleotide phosphate, NAADP(1+)

CAS 119299-06-8Formula C21H28N6O18P3+Molar mass 745.40 g/molEC 637-221-2
GHS signal word: Warning. Pictograms: Harmful or irritant 1 supplier listed
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Naadp+ chemical structure, C21H28N6O18P3+, CAS 119299-06-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
119299-06-8
Formula
C21H28N6O18P3+
Molar mass
745.40 g/mol
EC number
637-221-2
HS code
293499
Category
Nucleosides and nucleotides

What is Naadp+?

Plain description, key identifiers and synonyms

Nicotinic acid-adenine dinucleotide phosphate is a nicotinic acid dinucleotide that is NADP+ in which the carboxamide group on the pyridine ring is replaced by a carboxy group. It has a role as a metabolite, a calcium channel agonist and a signalling molecule. It is functionally related to a NADP(+). It is a conjugate acid of a nicotinate-adenine dinucleotide phosphate(4-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(2R,3R,4S,5R)-5-[[[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]pyridin-1-ium-3-carboxylic acid
CAS number
119299-06-8Other or deprecated CAS: 5502-96-5
EC number
637-221-2
Molecular formula
C21H28N6O18P3+
InChIKey
QOTXBMGJKFVZRD-HISDBWNOSA-O
InChI
InChI=1S/C21H27N6O18P3/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(44-46(33,34)35)14(29)11(43-20)6-41-48(38,39)45-47(36,37)40-5-10-13(28)15(30)19(42-10)26-3-1-2-9(4-26)21(31)32/h1-4,7-8,10-11,13-16,19-20,28-30H,5-6H2,(H6-,22,23,24,31,32,33,34,35,36,37,38,39)/p+1/t10-,11-,13-,14-,15-,16-,19-,20-/m1/s1
Canonical SMILES
Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)OCC2OC([n+]3cccc(C(=O)O)c3)C(O)C2O)C(O)C1OP(=O)(O)O
Isomeric SMILES
C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O)C(=O)O

Synonyms

  • beta-NAADP
  • nicotinic acid-adenine dinucleotide phosphate
  • NAADP(1+)
  • nicotinic acid-adenine dinucleotide phosphate(1+)
  • 2'-O-phosphonoadenosine 5'-{3-[1-(3-carboxypyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
745.40 g/molcalc.
Exact mass
745.0667 Dacalc.
LogP (octanol/water)
-2.3calc.
Topological polar surface area
359 Ųcalc.
Hydrogen bond donors
9calc.
Hydrogen bond acceptors
17calc.
Rotatable bonds
13calc.
Heavy atoms
48calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.48calc.
Formal charge
1calc.
Stereocentres
10calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH](OCC1CCC(n2cnc3cncnc32)O1)O[PH](=O)OCC1CCC([n+]2ccccc2)O1

O=[PH](OCC1CCC(n2cnc3cncnc32)O1)O[PH](=O)OCC1CCC([n+]2ccccc2)O1

5 rings, 34 atoms.

79 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Naadp+ suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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  • EvitaChem
    China, BeijingUnclaimed profile
    Naadp+Grade, purity and minimum order on request
    Price on request
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Where suppliers are based

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Naadp+ price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • biophysical role
  • calcium channel agonist
  • calcium channel modulator
  • membrane transport modulator
  • metabolite
  • molecular messenger
  • signalling molecule

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Naadp+ is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Naadp+ is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Naadp+, based on the data on this page

What is Naadp+?

Nicotinic acid-adenine dinucleotide phosphate is a nicotinic acid dinucleotide that is NADP+ in which the carboxamide group on the pyridine ring is replaced by a carboxy group. It has a role as a metabolite, a calcium channel agonist and a signalling molecule. It is functionally related to a NADP(+).

What is the CAS number of Naadp+?

The CAS registry number of Naadp+ is 119299-06-8. Other or deprecated CAS numbers: 5502-96-5.

What is the molecular formula and weight of Naadp+?

The molecular formula of Naadp+ is C21H28N6O18P3+ and its molar mass is 745.40 g/mol.

What is Naadp+ used for?

Known uses and roles of Naadp+ include biophysical role, calcium channel agonist, calcium channel modulator, membrane transport modulator, metabolite and 2 more.

Is Naadp+ hazardous?

Naadp+ carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Naadp+?

Naadp+ is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Naadp+?

CompoundList lists 1 supplier of Naadp+ in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Naadp+?

Suppliers quote Naadp+ on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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