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Screening compounds

Naftopidil

Also known as Flivas, Naftopidilum, 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol

CAS 57149-07-2Formula C24H28N2O3Molar mass 392.50 g/molEC 692-531-5
GHS signal word: Warning. Pictograms: Serious health hazard 37 suppliers listed
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Naftopidil chemical structure, C24H28N2O3, CAS 57149-07-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
57149-07-2
Formula
C24H28N2O3
Molar mass
392.50 g/mol
EC number
692-531-5
HS code
293359
Category
Screening compounds

What is Naftopidil?

Plain description, key identifiers and synonyms

Naftopidil is a member of piperazines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
CAS number
57149-07-2 CAS number cross-checked
EC number
692-531-5
Molecular formula
C24H28N2O3
UNII
R9PHW59SFN
MDL number
MFCD00242741, MFCD11046013
InChIKey
HRRBJVNMSRJFHQ-UHFFFAOYSA-N
InChI
InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
SMILES (canonical and isomeric)
COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O

Synonyms

  • Flivas
  • Naftopidilum
  • 1-(4-(2-methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol
  • 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol
  • 1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
  • 1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol
  • (2RS)-1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(naphthalen-1-yloxy)propan-2-ol
  • 4-(2-methoxyphenyl)-alpha-[(1-naphthalenyloxy)methyl]-1-piperazineethanol
  • (+/-)-Naftopidil
  • Avishot
  • 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
  • 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
  • Avishot,
  • Flivas (TN)
  • Naftopidil (Standard)
  • (+-)-1-(4-(2-Methoxyphenyl)piperazinyl)-3-(1-naphthyloxy)propan-2-ol
  • Naftopidil (JP18/INN)
  • (RS)-1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
  • 4-(2-Methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-1-pioerazineethanol
  • REGID_for_CID_4418
  • Naftopidil - Bio-X trade mark
  • (+-)-4-(o-Methoxyphenyl)-alpha-((1-naphthyloxy)methyl)-1-piperazineethanol
  • 1-Pioerazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-
  • Sdccgsbi-0050915.p003
  • 1-[4-(2-methoxyphenyl)piperazinyl]-3-naphthyloxypropan-2-ol
Show all 27 synonyms
  • 1-[4-(2-Methoxyphenyl)piperazinyl]-3-(1-naphthyloxy)propan-2-ol
  • 1-[4-(2-methoxyphenyl)piperazino]-3-(1-naphthoxy)propan-2-ol, hydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
392.50 g/molcalc.
Exact mass
392.21 Dacalc.
LogP (octanol/water)
3.41calc.
Topological polar surface area
45.17 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
7calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(N2CCN(CCCOc3cccc4ccccc34)CC2)cc1

c1ccc(N2CCN(CCCOc3cccc4ccccc34)CC2)cc1

4 rings, 26 atoms, the Piperazine, 1-(3-(1-naphthalenyloxy)propyl)-4-phenyl- ring system.

27 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Naftopidil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 37 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

37 suppliers in 13 countries

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Naftopidil price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adrenergic alpha-Antagonists
  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Platelet Aggregation Inhibitors

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Naftopidil is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Naftopidil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Naftopidil, based on the data on this page

What is Naftopidil?

Naftopidil is a member of piperazines.

What is the CAS number of Naftopidil?

The CAS registry number of Naftopidil is 57149-07-2.

What is the molecular formula and weight of Naftopidil?

The molecular formula of Naftopidil is C24H28N2O3 and its molar mass is 392.50 g/mol.

What is Naftopidil used for?

Known uses and roles of Naftopidil include building blocks in research and laboratory, screening compounds in research and laboratory, adrenergic alpha-antagonists, antihypertensive agents, calcium channel blockers and 1 more.

Is Naftopidil hazardous?

Naftopidil carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Naftopidil?

Naftopidil is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Naftopidil?

CompoundList lists 37 suppliers of Naftopidil in China, United States, Japan, Italy and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Naftopidil in India?

1 supplier in India list Naftopidil on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Naftopidil?

Suppliers quote Naftopidil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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