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Cosmetic antioxidants

Nobiletin

Also known as 5,6,7,8,3',4'-Hexamethoxyflavone, 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

CAS 478-01-3Formula C21H22O8Molar mass 402.40 g/mol
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Nobiletin chemical structure, C21H22O8, CAS 478-01-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
478-01-3
Formula
C21H22O8
Molar mass
402.40 g/mol
HS code
293299
Category
Cosmetic antioxidants

What is Nobiletin?

Plain description, key identifiers and synonyms

Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a flavone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
CAS number
478-01-3 CAS number cross-checked
Molecular formula
C21H22O8
UNII
D65ILJ7WLY
MDL number
MFCD03273560
INCI name
NOBILETIN
InChIKey
MRIAQLRQZPPODS-UHFFFAOYSA-N
InChI
InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
SMILES (canonical and isomeric)
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

Synonyms

  • 5,6,7,8,3',4'-Hexamethoxyflavone
  • 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
  • 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-
  • Hexamethoxyflavone
  • 3',4',5,6,7,8-Hexamethoxyflavone
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one
  • Flavone, 5,6,7,8,3',4'-hexamethoxy
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one
  • 3,4,5,6,7,8-Hexamethoxyflavone
  • nobiretin
  • nobliletin
  • hexamethoxy fl avone
  • Nobiletin (Standard)
  • Nobiletin, >=97%
  • Nobiletin (Hexamethoxyflavone)
  • Nobiletin, analytical standard
  • ACon1_000921
  • NOBILETIN, 20% (Technical Grade)
  • Sdccgmls-0066776.p001
  • 5,6,7,8,3'',4''-hexamethoxyflavone
  • Flavone, 3',4',5,6,7,8-hexamethoxy-
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H
  • 2-(3,4-Dimethoxy-phenyl)-5,6,7,8-tetramethoxy-chromen-4-one
  • 4H-1-Benzopyran-4-one,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-
Show all 26 synonyms
  • 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 9CI

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
402.40 g/molcalc.
Exact mass
402.1315 Dacalc.
LogP (octanol/water)
3.51calc.
Topological polar surface area
85.59 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
7calc.
Heavy atoms
29calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Nobiletin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 30 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

30 suppliers in 5 countries

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Nobiletin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name NOBILETIN(antimicrobial, antioxidant, preservative)

Pharmacological actions

  • Antioxidants

Roles

  • antineoplastic agent
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Functional uses

  • Antioxidant
  • Biocide
  • Preservative

Cosmetic functions

  • Antimicrobial
  • Antioxidant
  • Preservative

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nobiletin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nobiletin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nobiletin, based on the data on this page

What is Nobiletin?

Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively. It has a role as an antineoplastic agent and a plant metabolite. It is functionally related to a flavone.

What is the CAS number of Nobiletin?

The CAS registry number of Nobiletin is 478-01-3.

What is the molecular formula and weight of Nobiletin?

The molecular formula of Nobiletin is C21H22O8 and its molar mass is 402.40 g/mol.

What is Nobiletin used for?

Known uses and roles of Nobiletin include preservatives in cosmetics and personal care, antioxidants in cosmetics and personal care, antineoplastic agent, eukaryotic metabolite, metabolite and 7 more.

Is Nobiletin hazardous?

No GHS hazard classification for Nobiletin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Nobiletin?

Nobiletin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nobiletin?

CompoundList lists 30 suppliers of Nobiletin in China, United States, Germany, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Nobiletin?

Suppliers quote Nobiletin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nobiletin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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