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Oncology and immunology drugs

Olaparib

Also known as Lynparza, AZD 2281, Olaparibum

CAS 763113-22-0Formula C24H23FN4O3Molar mass 434.47 g/molEC 642-941-5
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard, Hazardous to the environment 140 suppliers listed Drug substance
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Olaparib chemical structure, C24H23FN4O3, CAS 763113-22-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
763113-22-0
Formula
C24H23FN4O3
Molar mass
434.47 g/mol
EC number
642-941-5
HS code
293359
Category
Oncology and immunology drugs

What is Olaparib?

Plain description, key identifiers and synonyms

Olaparib is a member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine, used to treat advanced ovarian cancer. It has a role as an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer. It is a member of phthalazines, a N-acylpiperazine, a member of cyclopropanes and a member of monofluorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
CAS number
763113-22-0Other or deprecated CAS: 1021843-02-6, 937799-91-2
EC number
642-941-5
Molecular formula
C24H23FN4O3
UNII
WOH1JD9AR8
MDL number
MFCD13185161
InChIKey
FDLYAMZZIXQODN-UHFFFAOYSA-N
InChI
InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
SMILES (canonical and isomeric)
C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Synonyms

  • Lynparza
  • AZD 2281
  • Olaparibum
  • 4-[[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one
  • 4-(3-{[4-(Cyclopropylcarbonyl)piperazin-1-Yl]carbonyl}-4-Fluorobenzyl)phthalazin-1(2h)-One
  • Keylynk-010 component olaparib
  • 4-{[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one
  • 4-[(3-{[4-(Cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorophenyl)methyl]phthalazin-1(2H)-one
  • 4-(3-((4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
  • 4-((3-((4-(Cyclopropylcarbonyl)piperazin-1-yl)carbonyl)-4-fluorophenyl)methyl)phthalazin-1(2H)-one
  • 4-((3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)methyl)-2H-phthalazin-1-one
  • 4-((3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorophenyl)methyl)-1,2-dihydrophthalazin-1-one
  • 4-((3-{(4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl}-4-fluorophenyl)methyl)phthalazin-1(2H)-one
  • PARP inhibitor AZD2281
  • 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine
  • 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
  • Olaparib (AZD2281)
  • OLAPARIB cpd
  • Olaparib (AZD-2281)
  • Olaparib (AZD2281, Ku-0059436)
  • 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
  • Olaparib (DISCONTINUED)
  • 1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-
  • 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one
  • 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one
Show all 31 synonyms
  • Olaparib, KU-0059436
  • 4-[3-[4-(Cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl]phthalazin-1(2H)-one
  • Lynparza (TN)
  • Olaparib (Standard)
  • AZD2281(olaparib)
  • KU 59436

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
434.47 g/molcalc.
Exact mass
434.1754 Dacalc.
LogP (octanol/water)
2.35calc.
Topological polar surface area
86.37 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
32calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCN(C(=O)C2CC2)CC1

O=C(c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1)N1CCN(C(=O)C2CC2)CC1

5 rings, 31 atoms, the 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one ring system.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H341Suspected of causing genetic defects.
  • H360May damage fertility or the unborn child.
  • H360DMay damage the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Olaparib suppliers

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All 140 suppliers
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Where suppliers are based

140 suppliers in 19 countries

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Olaparib price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antineoplastic Agents
  • Poly(ADP-ribose) Polymerase Inhibitors

Roles

  • antihypertensive agent
  • antineoplastic agent
  • apoptosis inducer
  • cardiovascular drug
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Olaparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of olaparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Olaparib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Olaparib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Olaparib, based on the data on this page

What is Olaparib?

Olaparib is a member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine, used to treat advanced ovarian cancer.

What is the CAS number of Olaparib?

The CAS registry number of Olaparib is 763113-22-0. Other or deprecated CAS numbers: 1021843-02-6, 937799-91-2.

What is the molecular formula and weight of Olaparib?

The molecular formula of Olaparib is C24H23FN4O3 and its molar mass is 434.47 g/mol.

What is Olaparib used for?

Known uses and roles of Olaparib include anticancer drugs in pharmaceuticals, antihypertensive agent, antineoplastic agent, apoptosis inducer, cardiovascular drug and 4 more.

Is Olaparib hazardous?

Olaparib carries the GHS signal word "Danger". Main hazards: toxic if swallowed, suspected of causing genetic defects, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Olaparib?

Olaparib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Olaparib?

CompoundList lists 140 suppliers of Olaparib in China, United States, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Olaparib in India?

13 suppliers in India list Olaparib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Olaparib?

Suppliers quote Olaparib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Olaparib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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