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Steroids and sterols

Oric-101

Also known as compound 28, compound 28 (PMID: 30091920), GR Antagonist ORIC-101

CAS 2222344-98-9Formula C34H47NO2Molar mass 501.76 g/mol
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Oric-101 chemical structure, C34H47NO2, CAS 2222344-98-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2222344-98-9
Formula
C34H47NO2
Molar mass
501.76 g/mol
HS code
292250
Category
Steroids and sterols

What is Oric-101?

Plain description, key identifiers and synonyms

Glucocorticoid Receptor Antagonist ORIC-101 is a mifepristone-based steroidal glucocorticoid receptor (GR) antagonist with potential antineoplastic activity. Upon oral administration, ORIC-101 selectively binds to GRs, thereby inhibiting the activation of GR-mediated proliferative and anti-apoptotic gene expression pathways. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance. Inhibition of GR activity may potentially slow tumor cell growth and disease progression in certain cancers. Due to its reduced androgen receptor (AR) agonistic activity and improved cytochrome P450 2C8 (CYP2C8) and 2C9 (CYP2C9) inhibition profile, ORIC-101 may be useful in the treatment of AR-positive tumors with reduced potential for drug-drug interactions.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
CAS number
2222344-98-9
Molecular formula
C34H47NO2
UNII
VI6E2D3CYP
InChIKey
VNLTWJIWEYPBIF-KMSLUKAPSA-N
InChI
InChI=1S/C34H47NO2/c1-22(2)35(7)25-11-8-23(9-12-25)29-21-33(6)30(16-17-34(33,37)19-18-32(3,4)5)28-14-10-24-20-26(36)13-15-27(24)31(28)29/h8-9,11-12,20,22,27-31,37H,10,13-17,21H2,1-7H3/t27-,28-,29+,30-,31+,33-,34+/m0/s1
Canonical SMILES
CC(C)N(C)c1ccc(C2CC3(C)C(CCC3(O)C#CC(C)(C)C)C3CCC4=CC(=O)CCC4C23)cc1
Isomeric SMILES
CC(C)N(C)C1=CC=C(C=C1)[C@H]2C[C@]3([C@@H](CC[C@]3(C#CC(C)(C)C)O)[C@H]4[C@H]2[C@H]5CCC(=O)C=C5CC4)C

Synonyms

  • compound 28
  • compound 28 (PMID: 30091920)
  • GR Antagonist ORIC-101
  • Glucocorticoid Receptor Antagonist ORIC-101
  • ORIC101
  • 19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-(4-(methyl(1-methylethyl)amino)phenyl)-, (11beta,17alpha)-
  • ORIC 101
  • ORIC-101?
  • 19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-(4-(methyl(1-methylethyl)amino)phenyl)-, (11beta,17.alpha.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
501.76 g/molcalc.
Exact mass
501.3607 Dacalc.
LogP (octanol/water)
7.15calc.
Topological polar surface area
40.54 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
37calc.
Rings
5calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.68calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2CCC3C4CCCC4CC(c4ccccc4)C3C2CC1

O=C1C=C2CCC3C4CCCC4CC(c4ccccc4)C3C2CC1

5 rings, 24 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Oric-101 suppliers

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Oric-101 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Oric-101 is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Oric-101 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Oric-101, based on the data on this page

What is Oric-101?

Glucocorticoid Receptor Antagonist ORIC-101 is a mifepristone-based steroidal glucocorticoid receptor (GR) antagonist with potential antineoplastic activity.

What is the CAS number of Oric-101?

The CAS registry number of Oric-101 is 2222344-98-9.

What is the molecular formula and weight of Oric-101?

The molecular formula of Oric-101 is C34H47NO2 and its molar mass is 501.76 g/mol.

Is Oric-101 hazardous?

No GHS hazard classification for Oric-101 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Oric-101?

Oric-101 is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Oric-101?

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What is the price of Oric-101?

Suppliers quote Oric-101 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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