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Cosmetic antioxidants

Palmatine

Also known as Berbericinine, O,O-Dimethyldemethyleneberberine, 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium

CAS 3486-67-7Formula C21H22NO4+Molar mass 352.41 g/mol
15 suppliers listed
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Palmatine chemical structure, C21H22NO4+, CAS 3486-67-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
3486-67-7
Formula
C21H22NO4+
Molar mass
352.41 g/mol
HS code
293979
Category
Cosmetic antioxidants

What is Palmatine?

Plain description, key identifiers and synonyms

Palmatine is a berberine alkaloid and an organic heterotetracyclic compound. It has a role as a plant metabolite.

Palmatine is a quaternary ammonium cation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
CAS number
3486-67-7 CAS number cross-checked
Molecular formula
C21H22NO4+
UNII
G50C034217
MDL number
MFCD00221758
INCI name
PALMATINE
InChIKey
QUCQEUCGKKTEBI-UHFFFAOYSA-N
InChI
InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1
SMILES (canonical and isomeric)
COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC

Synonyms

  • Berbericinine
  • O,O-Dimethyldemethyleneberberine
  • 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium
  • palmatine ion
  • palmatine cation
  • 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium
  • 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo(a,g)quinolizinium
  • 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium
  • 2,3,9,10-tetramethoxy-5,6-dihydroisoquino(3,2-a)isoquinolinium
  • Palmatin
  • Burasaine
  • Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-
  • 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
  • Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-
  • 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
  • 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium
  • Palmatine-chloride
  • Palmitine
  • 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium
  • 5-21-06-00202 (Beilstein Handbook Reference)
  • DivK1c_006715
  • DivK1c_006834
  • 2,3,9,10-tetramethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium
  • BERBINIUM, 7,8,13,13a-TETRAHYDRO-2,3,9,10-TETRAMETHOXY-
  • 2,3,9,10-tetramethoxy-protoberberine
Show all 27 synonyms
  • Sdccgmls-0066652.p001
  • Palmatine (negative marker) (constituent of goldenseal)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
352.41 g/molcalc.
Exact mass
352.1543 Dacalc.
LogP (octanol/water)
3.38calc.
Topological polar surface area
40.8 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
26calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
1calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC[n+]1cc3ccccc3cc1-2

c1ccc2c(c1)CC[n+]1cc3ccccc3cc1-2

4 rings, 18 atoms, the Protoberberine ring system.

57 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Palmatine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 15 suppliers
15 of 15 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

15 suppliers in 5 countries

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Palmatine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name PALMATINE(antioxidant)

Roles

  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Palmatine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Palmatine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Palmatine, based on the data on this page

What is Palmatine?

Palmatine is a berberine alkaloid and an organic heterotetracyclic compound. It has a role as a plant metabolite.

What is the CAS number of Palmatine?

The CAS registry number of Palmatine is 3486-67-7.

What is the molecular formula and weight of Palmatine?

The molecular formula of Palmatine is C21H22NO4+ and its molar mass is 352.41 g/mol.

What is Palmatine used for?

Known uses and roles of Palmatine include antioxidants in cosmetics and personal care, eukaryotic metabolite, metabolite, plant metabolite and antioxidant.

Is Palmatine hazardous?

No GHS hazard classification for Palmatine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Palmatine?

Palmatine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Palmatine?

CompoundList lists 15 suppliers of Palmatine in China, United States, France, Hong Kong and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Palmatine?

Suppliers quote Palmatine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Palmatine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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