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Murcko scaffold

Protoberberine scaffold

58 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
18
Chemicals
58
With full pages
19
Scaffold SMILES

c1ccc2c(c1)CC[n+]1cc3ccccc3cc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Protoberberine page
Murcko scaffold c1ccc2c(c1)CC[n+]1cc3ccccc3cc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

Palmatine chemical structure, C21H22NO4+, CAS 3486-67-7
Palmatine
CAS 3486-67-7C21H22NO4+
Dehydrocorydaline chemical structure, C22H24NO4+, CAS 30045-16-0
Dehydrocorydaline
CAS 30045-16-0C22H24NO4+
Columbamine iodide chemical structure, C20H20INO4, CAS 2007-07-0
Columbamine iodide
CAS 2007-07-0C20H20INO4
Columbamine chemical structure, C20H20NO4+, CAS 3621-36-1
Columbamine
CAS 3621-36-1C20H20NO4+
Jatrorrhizine chemical structure, C20H20NO4+, CAS 3621-38-3
Jatrorrhizine
CAS 3621-38-3C20H20NO4+
Palmatine chloride chemical structure, C21H22ClNO4, CAS 10605-02-4
Palmatine chloride
CAS 10605-02-4C21H22ClNO4
Protoberberine chemical structure, C17H14N+, CAS 19716-69-9
Protoberberine
CAS 19716-69-9C17H14N+
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-, iodide chemical structure, C22H24INO4, CAS 37553-95-0
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-, iodide
CAS 37553-95-0C22H24INO4
Dehydrodiscretine chemical structure, C20H20NO4+, CAS 68947-61-5
Dehydrodiscretine
CAS 68947-61-5C20H20NO4+
Dibenzo(a,g)quinolizinium, 5,6-dihydro-3,10-dihydroxy-2,9-dimethoxy-,chloride chemical structure, C19H18ClNO4, CAS 78134-82-4
Dibenzo(a,g)quinolizinium, 5,6-dihydro-3,10-dihydroxy-2,9-dimethoxy-,chloride
CAS 78134-82-4C19H18ClNO4
Dehydrodiscretamine chemical structure, C19H18NO4+, CAS 89560-99-6
Dehydrodiscretamine
CAS 89560-99-6C19H18NO4+
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-, chloride (1:1) chemical structure, C22H24ClNO4, CAS 10605-03-5
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-, chloride (1:1)
CAS 10605-03-5C22H24ClNO4
Pseudocolumbamine chemical structure, C20H20NO4+, CAS 64191-04-4
Pseudocolumbamine
CAS 64191-04-4C20H20NO4+
Dehydrocapaurimine chemical structure, C20H20ClNO5, CAS 57499-40-8
Dehydrocapaurimine
CAS 57499-40-8C20H20ClNO5
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1) chemical structure, C21H23NO5, CAS 131-04-4
Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1)
CAS 131-04-4C21H23NO5
Demethyleneberberine chloride chemical structure, C19H18ClNO4, CAS 16705-03-6
Demethyleneberberine chloride
CAS 16705-03-6C19H18ClNO4
Demethyleneberberine chemical structure, C19H18NO4+, CAS 25459-91-0
Demethyleneberberine
CAS 25459-91-0C19H18NO4+
Jatrorrhizine chloride chemical structure, C20H20ClNO4, CAS 6681-15-8
Jatrorrhizine chloride
CAS 6681-15-8C20H20ClNO4
2,3,9,10-Tetrahydroxyberberine chemical structure, C17H14NO4+, CAS 162854-37-7
2,3,9,10-Tetrahydroxyberberine
CAS 162854-37-7C17H14NO4+
Dibenzo[a,g]quinolizinium, 5,6-dihydro-3,4,10,11-tetramethoxy- chemical structure, C21H22NO4+, CAS 286000-57-5
Dibenzo[a,g]quinolizinium, 5,6-dihydro-3,4,10,11-tetramethoxy-
CAS 286000-57-5C21H22NO4+
Pseudopalmatine chemical structure, C21H22NO4+, CAS 19716-66-6
Pseudopalmatine
CAS 19716-66-6C21H22NO4+
Palmatine iodide chemical structure, C21H22INO4, CAS 4880-79-9
Palmatine iodide
CAS 4880-79-9C21H22INO4
Dehydrocorydalmine chemical structure, C20H20NO4+, CAS 6877-27-6
Dehydrocorydalmine
CAS 6877-27-6C20H20NO4+
Dehydrocorybulbine chemical structure, C21H22NO4+, CAS 59870-72-3
Dehydrocorybulbine
CAS 59870-72-3C21H22NO4+