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Screening compounds

Paltusotine

Also known as 3-(4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl)-2-hydroxybenzonitrile, 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile, CRN 00808

CAS 2172870-89-0Formula C27H22F2N4OMolar mass 456.50 g/mol
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Paltusotine chemical structure, C27H22F2N4O, CAS 2172870-89-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2172870-89-0
Formula
C27H22F2N4O
Molar mass
456.50 g/mol
HS code
293349
Category
Screening compounds

What is Paltusotine?

Plain description, key identifiers and synonyms

Paltusotine is an orally bioavailable, nonpeptide somatostatin receptor type 2 (SST2, SSTR2) agonist, with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities. Upon oral administration, paltusotine targets, binds to and activates SSTR2, which leads to an inhibition in the secretion of human growth hormone (hGH) in the pituitary gland and results in decreased production of insulin-like growth factor (IGF-1). This may inhibit IGF-1-mediated cell signaling pathways, and lead to apoptosis. SSTR2 is overexpressed by some neuroendocrine tumor cells, and GH is over-produced in the pituitary gland in acromegaly.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
CAS number
2172870-89-0
Molecular formula
C27H22F2N4O
UNII
F2IBD1GMD3
InChIKey
GHILNKWBALQPDP-UHFFFAOYSA-N
InChI
InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
SMILES (canonical and isomeric)
C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N

Synonyms

  • 3-(4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl)-2-hydroxybenzonitrile
  • 3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
  • CRN 00808
  • Benzonitrile, 3-(4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl)-2-hydroxy-
  • Benzonitrile, 3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-
  • Palsonify
  • Paltusotine dihydrochloride
  • Paltusotine?
  • 3-(4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl)-2-hydroxybenzonitrile dihydrochloride
  • Paltusotine (USAN/INN)
  • Paltusotine (crn00808)
  • US10351547, Compound 2-2
  • compound 22
  • 3-[4-(4-Amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxybenzonitrile
  • IUD
  • Paltusotine,Somatostatin Receptor,CRN-00808,CRN 00808,Inhibitor,IGF-1,orally,CRN00808,SSTR,inhibit,SSTRs

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
456.50 g/molcalc.
Exact mass
456.1762 Dacalc.
LogP (octanol/water)
5.35calc.
Topological polar surface area
86.17 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
3calc.
Heavy atoms
34calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.19calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2ccc3ncc(-c4ccccc4)c(N4CCCCC4)c3c2)cc1

c1ccc(-c2ccc3ncc(-c4ccccc4)c(N4CCCCC4)c3c2)cc1

5 rings, 28 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Paltusotine suppliers

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Where suppliers are based

1 supplier in 1 country

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Paltusotine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Paltusotine is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Paltusotine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Paltusotine, based on the data on this page

What is Paltusotine?

Paltusotine is an orally bioavailable, nonpeptide somatostatin receptor type 2 (SST2, SSTR2) agonist, with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities.

What is the CAS number of Paltusotine?

The CAS registry number of Paltusotine is 2172870-89-0.

What is the molecular formula and weight of Paltusotine?

The molecular formula of Paltusotine is C27H22F2N4O and its molar mass is 456.50 g/mol.

What is Paltusotine used for?

Known uses and roles of Paltusotine include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Paltusotine hazardous?

No GHS hazard classification for Paltusotine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Paltusotine?

Paltusotine is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Paltusotine?

CompoundList lists 1 supplier of Paltusotine in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Paltusotine?

Suppliers quote Paltusotine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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