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Coenzymes and cofactors

Pantethine

Also known as D-Pantethine, Pantomin, Pantetina

CAS 16816-67-4Formula C22H42N4O8S2Molar mass 554.73 g/molEC 240-842-8
GHS signal word: Warning. Pictograms: Hazardous to the environment 10 suppliers listed
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Pantethine chemical structure, C22H42N4O8S2, CAS 16816-67-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
16816-67-4
Formula
C22H42N4O8S2
Molar mass
554.73 g/mol
EC number
240-842-8
HS code
293090
Category
Coenzymes and cofactors

What is Pantethine?

Plain description, key identifiers and synonyms

Pantethine is an organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group. It has a role as a coenzyme and a nutraceutical. It is functionally related to a pantothenic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
CAS number
16816-67-4 CAS number cross-checkedOther or deprecated CAS: 644967-47-5
EC number
240-842-8
Molecular formula
C22H42N4O8S2
UNII
7K81IL792L
MDL number
MFCD07357234
INCI name
PANTETHINE
InChIKey
DJWYOLJPSHDSAL-ROUUACIJSA-N
InChI
InChI=1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1
Canonical SMILES
CC(C)(CO)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO
Isomeric SMILES
CC(C)(CO)[C@H](C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO)O)O

Synonyms

  • D-Pantethine
  • Pantomin
  • Pantetina
  • Pantosin
  • Bis(pantothenamidoethyl) disulfide
  • D-Bis(N-pantothenyl-beta-aminoethyl) disulfide
  • Bis(N-pantothenylamidoethyl) disulfide
  • D-Bis(N-pantothenyl-2-aminoethyl)-disulfide
  • (2R)-N-[2-({2-[(2-{3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanamido}ethyl)disulfanyl]ethyl}carbamoyl)ethyl]-2,4-dihydroxy-3,3-dimethylbutanamide
  • Butanamide, N,N'-(dithiobis(2,1-ethanediylimino(3-oxo-3,1-propanediyl)))bis(2,4-dihydroxy-3,3-dimethyl-, (2R,2'r)-
  • Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)-
  • (2R)-N-(2-((2-((2-(3-((2R)-2,4-dihydroxy-3,3-dimethylbutanamido)propanamido)ethyl)disulfanyl)ethyl)carbamoyl)ethyl)-2,4-dihydroxy-3,3-dimethylbutanamide
  • Bis(2-(3-((2R)-2,4-dihydroxy-3,3-dimethylbutanoylamino)propanoylamino)ethyl) disulfide
  • (2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
  • Lipodel
  • (2R,2'R)-N,N'-(((Disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2,4-dihydroxy-3,3-dimethylbutanamide)
  • LBF disulfide
  • (2R,2'R)-N,N'-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide]
  • (R-(R*,R*))-N,N'-(Dithiobis(ethyleneimino(3-oxopropane-3,1-diyl)))bis(2,4-dihydroxy-3,3-dimethylbutyramide)
  • Pantosin (TN)
  • D-pantethine anhydrous
  • D-Pantethine, LBF disulfide
  • Pantethine (Standard)
  • Pantethine, D-(p)
  • D-Pantethine, analytical standard
Show all 32 synonyms
  • Butanamide, N,N'-(dithiobis(2,1-ethanediylimino(3-oxo-3,1-propanediyl)))bis(2- ,4-dihydroxy-3,3-dimethyl-
  • Butyramide, N,N'-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,3-dimethyl-, D-(+)-
  • N,N'-(Dithiobis(2,1-ethanediylimino(3-oxo-3,1-propanediyl)))bis(2- ,4-dihydroxy-3,3-dimethylbutanamide
  • D-Bis(N-pantothenyl-2-aminoethyl)-disulphide
  • (2R,2'R)-N,N'-{Disulfanediylbis[ethane-2,1-diylazanediyl(3-oxopropane-3,1-diyl)]}bis(2,4-dihydroxy-3,3-dimethylbutanamide)
  • (2R,2'R)-N,N'-{disulfanediylbis[ethane-2,1-diylimino(3-oxopropane-3,1-diyl)]}bis(2,4-dihydroxy-3,3-dimethylbutanamide)
  • N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
554.73 g/molcalc.
Exact mass
554.2444 Dacalc.
LogP (octanol/water)
-1.63calc.
Topological polar surface area
197.3 Ųcalc.
Hydrogen bond donors
8calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
19calc.
Heavy atoms
36calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.82calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H400Very toxic to aquatic life.
Precautionary statements (3)
  • P273Avoid release to the environment.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pantethine suppliers

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Where suppliers are based

10 suppliers in 2 countries

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Pantethine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name PANTETHINE(skin conditioning - emollient, hair conditioning)

Roles

  • coenzyme
  • cofactor
  • nutraceutical
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Hair conditioning
  • Skin conditioning - emollient

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pantethine is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Pantethine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pantethine, based on the data on this page

What is Pantethine?

Pantethine is an organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group. It has a role as a coenzyme and a nutraceutical. It is functionally related to a pantothenic acid.

What is the CAS number of Pantethine?

The CAS registry number of Pantethine is 16816-67-4. Other or deprecated CAS numbers: 644967-47-5.

What is the molecular formula and weight of Pantethine?

The molecular formula of Pantethine is C22H42N4O8S2 and its molar mass is 554.73 g/mol.

What is Pantethine used for?

Use classes: Cosmetics.

Is Pantethine hazardous?

Pantethine carries the GHS signal word "Warning". Main hazards: very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pantethine?

Pantethine is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pantethine?

CompoundList lists 10 suppliers of Pantethine in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pantethine?

Suppliers quote Pantethine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pantethine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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