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Analgesics and anti-inflammatories

Penicillamine

Also known as D-Penicillamine, Cuprimine, D-(-)-Penicillamine

CAS 52-67-5Formula C5H11NO2SMolar mass 149.22 g/molEC 200-148-8
GHS signal word: Warning. Pictograms: Harmful or irritant 99 suppliers listed Drug substance
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Penicillamine chemical structure, C5H11NO2S, CAS 52-67-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Fine, white or practically white, crystalline powder
Melting point
202 to 206
Solubility
CRYSTALS, DECOMP 177.5 °C, SPECIFIC OPTICAL ROTATION: -63 DEG @ 25 °C/D (1N SODIUM HYDRO…
HS code
293090
Category
Analgesics and anti-inflammatories
Illustrative photo, off-white crystalline powder with an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Penicillamine?

Plain description, key identifiers and synonyms

D-penicillamine is an optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. It has a role as a copper chelator, an antirheumatic drug, a chelator and a drug allergen. It is a penicillamine and a non-proteinogenic alpha-amino acid. It is an enantiomer of a L-penicillamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-methyl-3-sulfanylbutanoic acid
CAS number
52-67-5 CAS number cross-checkedOther or deprecated CAS: 771431-20-0
EC number
200-148-8
Molecular formula
C5H11NO2S
UNII
GNN1DV99GX
MDL number
MFCD00064302
InChIKey
VVNCNSJFMMFHPL-VKHMYHEASA-N
InChI
InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
Canonical SMILES
CC(C)(S)C(N)C(=O)O
Isomeric SMILES
CC(C)([C@H](C(=O)O)N)S

Synonyms

  • D-Penicillamine
  • Cuprimine
  • D-(-)-Penicillamine
  • 3-Mercapto-D-valine
  • (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid
  • Depen
  • (-)-Penicillamine
  • Cuprenil
  • Cupripen
  • D-Valine, 3-mercapto-
  • Kuprenil
  • Trolovol
  • (S)-3,3-Dimethylcysteine
  • Mercaptovaline
  • Penicilamina
  • D-3-Mercaptovaline
  • Penicillaminum
  • D-beta,beta-Dimethylcysteine
  • Penicillamina
  • Sufortan
  • (S)-2-amino-3-mercapto-3-methylbutanoic acid
  • Dimethylcysteine
  • beta,beta-Dimethylcysteine
  • Distamine
  • D Penicillamine
Show all 38 synonyms
  • D 3 Mercaptovaline
  • Penicillaminate, Copper
  • beta,beta Dimethylcysteine
  • Kelatin
  • Atamir
  • D Mercaptovaline
  • (2S)-2-azaniumyl-3-methyl-3-sulfanylbutanoate
  • (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid, 3-sulfanyl-D-valine
  • 3,3-dimethylcysteine
  • D,L-Penicillamine
  • DL-3-Mercaptovaline
  • Artamine
  • H-D-Pen-OH

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Fine, white or practically white, crystalline powderexp.
Odour
SLIGHT CHARACTERISTIC ODORexp.
Taste
SLIGHTLY BITTERexp.
Melting point
202 to 206exp.
Solubility
CRYSTALS, DECOMP 177.5 °C, SPECIFIC OPTICAL ROTATION: -63 DEG @ 25 °C/D (1N SODIUM HYDROXIDE), HYGROSCOPIC, FREELY SOL IN WATER, SOL IN ETHANOL. /D-PENICILLAMINE HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
149.22 g/molcalc.
Exact mass
149.0511 Dacalc.
LogP (octanol/water)
0.11calc.
Topological polar surface area
63.32 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
9calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Penicillamine suppliers

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Where suppliers are based

99 suppliers in 15 countries

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Penicillamine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Experimental inducer of convulsions in rats. (L-Penicillamine).

Pharmacological actions

  • Antidotes
  • Antirheumatic Agents
  • Chelating Agents

Roles

  • aetiopathogenetic role
  • allergen
  • antirheumatic drug
  • chelator
  • copper chelator
  • drug allergen
  • ligand
  • pharmaceutical

Pharmacology

Penicillamine is an Antirheumatic Agent.

How it is made

By acid hydrolysis of penicillin. It is pptd from hydrolysis mixt as mercuric salt which is then collected, suspended in water, & treated with hydrogen sulfide to liberate free acid. Purification involves only recrystallization from water.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Penicillamine is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Penicillamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Penicillamine, based on the data on this page

What is Penicillamine?

D-penicillamine is an optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. It has a role as a copper chelator, an antirheumatic drug, a chelator and a drug allergen.

What is the CAS number of Penicillamine?

The CAS registry number of Penicillamine is 52-67-5. Other or deprecated CAS numbers: 771431-20-0.

What is the molecular formula and weight of Penicillamine?

The molecular formula of Penicillamine is C5H11NO2S and its molar mass is 149.22 g/mol.

What is Penicillamine used for?

Experimental inducer of convulsions in rats. (L-Penicillamine).

Is Penicillamine hazardous?

Penicillamine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Penicillamine?

Penicillamine is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Penicillamine?

CompoundList lists 99 suppliers of Penicillamine in United States, China, India, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Penicillamine in India?

12 suppliers in India list Penicillamine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Penicillamine?

Suppliers quote Penicillamine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Penicillamine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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