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Central nervous system drugs

Pergolide

Also known as Pergolida, Pergolidum, Parkotil

CAS 66104-22-1Formula C19H26N2SMolar mass 314.50 g/molEC 811-107-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 33 suppliers listed Drug substance
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Pergolide chemical structure, C19H26N2S, CAS 66104-22-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
66104-22-1
Formula
C19H26N2S
Molar mass
314.50 g/mol
EC number
811-107-4
HS code
293969
Category
Central nervous system drugs

What is Pergolide?

Plain description, key identifiers and synonyms

Pergolide is a diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. It has a role as an antiparkinson drug and a dopamine agonist. It is a diamine, an organic heterotetracyclic compound and a methyl sulfide. It is a conjugate base of a pergolide(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline
CAS number
66104-22-1 CAS number cross-checked
EC number
811-107-4
Molecular formula
C19H26N2S
UNII
24MJ822NZ9
InChIKey
YEHCICAEULNIGD-MZMPZRCHSA-N
InChI
InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
Canonical SMILES
CCCN1CC(CSC)CC2c3cccc4[nH]cc(c34)CC21
Isomeric SMILES
CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC

Synonyms

  • Pergolida
  • Pergolidum
  • Parkotil
  • Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-
  • (2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene
  • (2R,4R,7R)-4-((methylsulfanyl)methyl)-6-propyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),9,12,14-tetraene
  • (2R,4R,7R)-4-((methylsulfanyl)methyl)-6-propyl-6,11-diazatetracyclo(7.6.1.02,7.012,16)hexadeca-1(16),9,12,14-tetraene
  • 8beta-[(Methylthio)methyl]-6-propylergoline
  • Pergolide (INN)
  • (6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline
  • Permax (TN)
  • LY 141B
  • Biomol-NT_000025
  • (8beta)-8-[(methylthio)methyl]-6-propylergoline
  • DivK1c_000442
  • (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
  • Sdccgsbi-0050957.p004
  • (6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
  • [2-(1H-Indol-4-yl)-ethyl]-methyl-amine
  • D-8beta-((Methylthio)methyl)-6-propylergoline
  • 8beta-[(Methylsulfanyl)methyl]-6-propylergoline
  • 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
  • (2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(15),9,12(16),13-tetraene
  • (6aR,9R,10aR)-9-((methylthio)methyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
314.50 g/molcalc.
Exact mass
314.1817 Dacalc.
LogP (octanol/water)
4.27calc.
Topological polar surface area
19.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.58calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c[nH]c3c1)CC1NCCCC21

c1cc2c3c(c[nH]c3c1)CC1NCCCC21

4 rings, 16 atoms.

219 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H351Suspected of causing cancer.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (10)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pergolide suppliers

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All 33 suppliers
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Where suppliers are based

33 suppliers in 11 countries

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Pergolide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Dopamine Agonists

Roles

  • antidyskinesia agent
  • antiparkinson drug
  • dopamine agonist
  • dopaminergic agent
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Pergolide is an Ergot-derived Dopamine Receptor Agonist. The mechanism of action of pergolide is as a Dopamine Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pergolide is traded under.

HS 2939.69Indicative HS code

Alkaloids of rye ergot and their derivatives, salts thereof, other

World exports in 2024
$66.7M
+1.1% vs 2023, imports $78M
2019 to 2024
Top exporters
  1. Czech Republic62.5%
  2. Italy14.4%
  3. United States3.7%
Top importers
  1. Japan25.8%
  2. China11.3%
  3. United States7.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Pergolide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pergolide, based on the data on this page

What is Pergolide?

Pergolide is a diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group.

What is the CAS number of Pergolide?

The CAS registry number of Pergolide is 66104-22-1.

What is the molecular formula and weight of Pergolide?

The molecular formula of Pergolide is C19H26N2S and its molar mass is 314.50 g/mol.

What is Pergolide used for?

Use classes: Pharmaceuticals.

Is Pergolide hazardous?

Pergolide carries the GHS signal word "Danger". Main hazards: fatal if swallowed, suspected of causing cancer, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pergolide?

Pergolide is usually classified under HS code 293969 (Alkaloids of rye ergot and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pergolide?

CompoundList lists 33 suppliers of Pergolide in United States, China, United Kingdom, Japan and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pergolide?

Suppliers quote Pergolide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pergolide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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