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Pharmaceuticals and APIs

Phenylephrine hydrochloride

Also known as Phenylephrine HCl, Biomydrin, Mydfrin

CAS 61-76-7Formula C9H14ClNO2Molar mass 203.67 g/molEC 200-517-3
GHS signal word: Warning. Pictograms: Harmful or irritant 127 suppliers listed Drug substance
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Phenylephrine hydrochloride chemical structure, C9H14ClNO2, CAS 61-76-7
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Powder
Melting point
140 to 145
Solubility
Greater than or equal to 100 mg/mL at 70 °F
HS code
292250
Category
Pharmaceuticals and APIs
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Phenylephrine hydrochloride?

Plain description, key identifiers and synonyms

Phenylephrine Hydrochloride is the hydrochloride salt form of phenylephrine, a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol, hydrochloride
CAS number
61-76-7 CAS number cross-checked
EC number
200-517-3
Molecular formula
C9H14ClNO2
UNII
04JA59TNSJ
MDL number
MFCD00012605
InChIKey
OCYSGIYOVXAGKQ-FVGYRXGTSA-N
InChI
InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
Canonical SMILES
CNCC(O)c1cccc(O)c1.Cl
Isomeric SMILES
CNC[C@@H](C1=CC(=CC=C1)O)O.Cl

Synonyms

  • Phenylephrine HCl
  • Biomydrin
  • Mydfrin
  • Nostril
  • (R)-Phenylephrine hydrochloride
  • Neo-Synephrine
  • L-Phenylephrine hydrochloride
  • Almefrin
  • Consdrin
  • Fenilfar
  • Histabid
  • Idrianol
  • Neophryn
  • Neosympatol
  • Oftalfrine
  • Phenistan
  • Pyristan
  • Stanephrin
  • Sucraphen
  • Synethenate
  • Vazculep
  • Efricel
  • Emagrin
  • Lexatol
  • Prefrin
Show all 39 synonyms
  • Rhinall
  • Synasal
  • Fenox
  • meta-Sympatol
  • Alcon-efrin
  • OP-Isophrin
  • Neo-Synesin 1
  • Metaoxedrine chloride
  • (-)-Phenylephrine hydrochloride
  • Consdrin hydrochloride
  • Isophrin hydrochloride
  • Metaoxedrine hydrochloride
  • meta-Synephrine hydrochloride
  • Levophenylephrine hydrochloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Powderexp.
Melting point
140 to 145exp.
Solubility
Greater than or equal to 100 mg/mL at 70 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
203.67 g/molcalc.
Exact mass
203.0713 Dacalc.
LogP (octanol/water)
1.07calc.
Topological polar surface area
52.49 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (22)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phenylephrine hydrochloride suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 127 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

127 suppliers in 19 countries

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Phenylephrine hydrochloride price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Functional uses

  • Pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phenylephrine hydrochloride is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Phenylephrine hydrochloride is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phenylephrine hydrochloride, based on the data on this page

What is Phenylephrine hydrochloride?

Phenylephrine Hydrochloride is the hydrochloride salt form of phenylephrine, a direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property.

What is the CAS number of Phenylephrine hydrochloride?

The CAS registry number of Phenylephrine hydrochloride is 61-76-7.

What is the molecular formula and weight of Phenylephrine hydrochloride?

The molecular formula of Phenylephrine hydrochloride is C9H14ClNO2 and its molar mass is 203.67 g/mol.

What is Phenylephrine hydrochloride used for?

Known uses and roles of Phenylephrine hydrochloride include pharmaceutical.

Is Phenylephrine hydrochloride hazardous?

Phenylephrine hydrochloride carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phenylephrine hydrochloride?

Phenylephrine hydrochloride is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phenylephrine hydrochloride?

CompoundList lists 127 suppliers of Phenylephrine hydrochloride in India, United States, China, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Phenylephrine hydrochloride in India?

37 suppliers in India list Phenylephrine hydrochloride on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Phenylephrine hydrochloride?

Suppliers quote Phenylephrine hydrochloride on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phenylephrine hydrochloride

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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