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Vitamins and nutraceutical actives

Phylloquinone

Also known as Vitamin k1, phytonadione, Phytomenadione

CAS 84-80-0Formula C31H46O2Molar mass 450.71 g/molEC 201-564-2
GHS signal word: Warning. Pictograms: Harmful or irritant 155 suppliers listed Drug substance
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Phylloquinone chemical structure, C31H46O2, CAS 84-80-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow viscous oil
Melting point
-20 °C
Boiling point
140 to 145
Density
0.964 @ 25 °C/25 °C
Solubility
Colorless oil, UV max (95% alcohol): 259, 305 nm (log Em 3.79, 3.31), insol in water /2,…
HS code
293629
Category
Vitamins and nutraceutical actives
Illustrative photo, amber viscous liquid in an open pail in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Phylloquinone?

Plain description, key identifiers and synonyms

Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a member of phylloquinones and a vitamin K.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
CAS number
84-80-0 CAS number cross-checkedOther or deprecated CAS: 10485-69-5, 11104-38-4, 79083-00-4
EC numbers
201-564-2, 234-330-3, 279-052-3
Molecular formula
C31H46O2
UNII
MLF3D1712D, S5Z3U87QHF
MDL number
MFCD00214063
InChIKey
MBWXNTAXLNYFJB-NKFFZRIASA-N
InChI
InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
Canonical SMILES
CC(=CCC1=C(C)C(=O)c2ccccc2C1=O)CCCC(C)CCCC(C)CCCC(C)C
Isomeric SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C

Synonyms

  • Vitamin k1
  • phytonadione
  • Phytomenadione
  • Phytylmenadione
  • Mephyton
  • 3-Phytylmenadione
  • Monodion
  • Synthex P
  • Phyllochinon
  • Kinadion
  • Kephton
  • Mono-Kay
  • Combinal K1
  • Fitomenadiona
  • Kativ N
  • alpha-Phylloquinone
  • trans-Phylloquinone
  • K-Ject
  • 2-Methyl-3-phytyl-1,4-naphthoquinone
  • Antihemorrhagic vitamin
  • Phyllochinonum
  • Phytomenadionum
  • Phytonadionum
  • Orakay
  • Aqua mephyton
Show all 39 synonyms
  • Fitomenadione
  • Vitamin K 1
  • 2',3'-trans-Vitamin K1
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • Kanavit
  • Neokay
  • Konakion mm
  • Vitamin K1(20)
  • Konakion mm paed
  • 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
  • 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
  • 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione
  • 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
  • vitaminum k1

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow viscous oilexp.
Odour
Odorlessexp.
Melting point
-20 °Cexp.
Boiling point
140 to 145exp.
Density
0.964 @ 25 °C/25 °Cexp.
Solubility
Colorless oil, UV max (95% alcohol): 259, 305 nm (log Em 3.79, 3.31), insol in water /2,3-Epoxide/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
450.71 g/molcalc.
Exact mass
450.3498 Dacalc.
LogP (octanol/water)
9.16calc.
Topological polar surface area
34.14 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
14calc.
Heavy atoms
33calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC(=O)c2ccccc21

O=C1C=CC(=O)c2ccccc21

2 rings, 12 atoms, the 1,4-Naphthoquinone ring system.

875 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (9)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Phylloquinone suppliers

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All 155 suppliers
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Where suppliers are based

155 suppliers in 23 countries

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Phylloquinone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Cosmetics.

Pharmacological actions

  • Antifibrinolytic Agents
  • Vitamins

Roles

  • animal metabolite
  • anti-HBV agent
  • anti-inflammatory agent
  • antifibrotic agent
  • antimicrobial agent
  • antineoplastic agent
  • antirheumatic drug
  • antiviral agent
  • bone density conservation agent
  • cardiovascular drug
  • cofactor
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Functional uses

  • Softener and conditioner

Pharmacology

Phytonadione is a Vitamin K and Warfarin Reversal Agent. The physiologic effect of phytonadione is by means of Increased Prothrombin Activity and Reversed Anticoagulation Activity.

How it is made

Partial syntheses from menadione and phytol ... Synthesis using a pi-allylic nickel(I) complex...

Synthetically from 2-methyl-1,4-naphthoquinone and phytol.

The first syntheses and structural elucidation of phylloquinone were published in 1939 almost simultaneously by four groups. The starting materials were menadione or menadiol as the aromatic component and natural phytol or one of its derivatives. A breakthrough in commercial synthesis was achieved in the 1950s, when it was found that monoacylated menadiols (e.g. the monoacetate or the monobenzoate) could be used advantageously in the alkylation step and that natural phytol could be replaced by isophytol, which is easy to synthesize.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Phytonadione [INCI], phytomenadione [INN], Ref no: 1371, Annex ref: II/1371
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Phylloquinone is traded under.

HS 2936.29Indicative HS code

Vitamins and their derivatives, unmixed, other vitamins and their derivatives

World exports in 2024
$2.21B
+8.7% vs 2023, imports $1.85B
2019 to 2024
Top exporters
  1. China25.3%
  2. United States14.5%
  3. Australia13.8%
Top importers
  1. United States16.4%
  2. Netherlands9.4%
  3. Spain5.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Phylloquinone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Phylloquinone, based on the data on this page

What is Phylloquinone?

Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite.

What is the CAS number of Phylloquinone?

The CAS registry number of Phylloquinone is 84-80-0. Other or deprecated CAS numbers: 10485-69-5, 11104-38-4, 79083-00-4.

What is the molecular formula and weight of Phylloquinone?

The molecular formula of Phylloquinone is C31H46O2 and its molar mass is 450.71 g/mol.

What is Phylloquinone used for?

Veterinary medication:. Use classes: Cosmetics.

Is Phylloquinone hazardous?

Phylloquinone carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Phylloquinone?

Phylloquinone is usually classified under HS code 293629 (Vitamins and their derivatives, unmixed, other vitamins and their derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Phylloquinone?

CompoundList lists 155 suppliers of Phylloquinone in China, United States, India, Germany and 19 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Phylloquinone in India?

19 suppliers in India list Phylloquinone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Phylloquinone?

Suppliers quote Phylloquinone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Phylloquinone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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