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Screening compounds

Pifithrin

Also known as Pifithrin-alpha, PFT-alpha, 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide (1:1)

CAS 63208-82-2Formula C16H19BrN2OSMolar mass 367.31 g/mol
13 suppliers listed
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Pifithrin chemical structure, C16H19BrN2OS, CAS 63208-82-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
63208-82-2
Formula
C16H19BrN2OS
Molar mass
367.31 g/mol
HS code
293420
Category
Screening compounds

What is Pifithrin?

Plain description, key identifiers and synonyms

Pifithrin-alpha hydrobromide is a hydrobromide salt prepared from 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone and one equivalent of hydrogen bromide. It is a chemical that inhibits p53-mediated gene activation and apoptosis. It has a role as a p53 inhibitor, a hepatoprotective agent, an apoptosis inhibitor and an aryl hydrocarbon receptor agonist. It contains a 3-[2-(4-methylphenyl)-2-oxoethyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-2(3H)-iminium.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone, hydrobromide
CAS number
63208-82-2 CAS number cross-checked
Molecular formula
C16H19BrN2OS
UNII
D213B92S1Y
MDL number
MFCD00417851
InChIKey
HAGVCKULCLQGRF-UHFFFAOYSA-N
InChI
InChI=1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
SMILES (canonical and isomeric)
CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br

Synonyms

  • Pifithrin-alpha
  • PFT-alpha
  • 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide (1:1)
  • Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)
  • 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
  • PFT alpha
  • 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone
  • Pifithrin-alpha hydrobromide
  • pifithrin alpha
  • 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone,hydrobromide
  • PFTalpha
  • Pifithrin-|A (PFT|A)
  • 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide
  • Pifithrin-a hydrobromide
  • 2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-p-tolylethanone hydrobromide
  • 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone, hydrobromide
  • Pifithrin-alpha (PFTalpha)
  • 2-(2-imino-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethan-1-one hydrobromide
  • Pifithrin-alpha HBr
  • Pifithrin hydrobromide
  • C16H19BrN2OS
  • Pifithrin- alpha hydrobromide
  • Pifithrin- (pft)
  • PFT-a
  • Pifithrin-_ (PFT_)
Show all 33 synonyms
  • A) HBr
  • Pifithrin- (PFT) HBr
  • Pifithrin-alpha (hydrobromide)?
  • Pifithrin-f inverted question mark
  • Pifithrin-? (PFT?) Hhydrobromide
  • Pifithrin-alpha, >=95% (HPLC), powder
  • https://pubmed.ncbi.nlm.nih.gov/?term=Pifithrin-alpha+&sort=date
  • 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone . HBr

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
367.31 g/molcalc.
Exact mass
366.0401 Dacalc.
LogP (octanol/water)
3.68calc.
Topological polar surface area
45.85 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, N=c1sc2c(n1CC(=O)c1ccccc1)CCCC2

N=c1sc2c(n1CC(=O)c1ccccc1)CCCC2

3 rings, 19 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Pifithrin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
13 of 13 offers

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Where suppliers are based

13 suppliers in 3 countries

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Pifithrin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • apoptosis inhibitor
  • aryl hydrocarbon receptor agonist
  • hepatoprotective agent
  • p53 inhibitor
  • pharmaceutical
  • protective agent

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pifithrin is traded under.

HS 2934.20Indicative HS code

Compounds containing in the structure a benzothiazole ring-system (whether or not…

World exports in 2024
$662M
+4.3% vs 2023, imports $630M
2019 to 2024
Top exporters
  1. China62.9%
  2. Belgium14.6%
  3. United States5.4%
Top importers
  1. India * partner reported18.5%
  2. United States18.1%
  3. Brazil6.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pifithrin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pifithrin, based on the data on this page

What is Pifithrin?

Pifithrin-alpha hydrobromide is a hydrobromide salt prepared from 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone and one equivalent of hydrogen bromide. It is a chemical that inhibits p53-mediated gene activation and apoptosis.

What is the CAS number of Pifithrin?

The CAS registry number of Pifithrin is 63208-82-2.

What is the molecular formula and weight of Pifithrin?

The molecular formula of Pifithrin is C16H19BrN2OS and its molar mass is 367.31 g/mol.

What is Pifithrin used for?

Known uses and roles of Pifithrin include building blocks in research and laboratory, screening compounds in research and laboratory, agonist, apoptosis inhibitor, aryl hydrocarbon receptor agonist and 4 more.

Is Pifithrin hazardous?

No GHS hazard classification for Pifithrin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Pifithrin?

Pifithrin is usually classified under HS code 293420 (Compounds containing in the structure a benzothiazole ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pifithrin?

CompoundList lists 13 suppliers of Pifithrin in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Pifithrin?

Suppliers quote Pifithrin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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