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Central nervous system drugs

Pimozide

Also known as Orap, Opiran, Pimozidum

CAS 2062-78-4Formula C28H29F2N3OMolar mass 461.56 g/molEC 218-171-7
GHS signal word: Warning. Pictograms: Harmful or irritant 77 suppliers listed Drug substance
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Pimozide chemical structure, C28H29F2N3O, CAS 2062-78-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2062-78-4
Formula
C28H29F2N3O
Molar mass
461.56 g/mol
EC number
218-171-7
HS code
293339
Category
Central nervous system drugs

What is Pimozide?

Plain description, key identifiers and synonyms

Pimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group. It has a role as a H1-receptor antagonist, a serotonergic antagonist, a dopaminergic antagonist, a first generation antipsychotic and an antidyskinesia agent. It is a member of benzimidazoles, an organofluorine compound and a heteroarylpiperidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
CAS number
2062-78-4 CAS number cross-checked
EC number
218-171-7
Molecular formula
C28H29F2N3O
UNII
1HIZ4DL86F
MDL number
MFCD00055081
InChIKey
YVUQSNJEYSNKRX-UHFFFAOYSA-N
InChI
InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
SMILES (canonical and isomeric)
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F

Synonyms

  • Orap
  • Opiran
  • Pimozidum
  • McN-JR-6238
  • pimozida
  • 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
  • 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • Orap forte
  • 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
  • 3-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzimidazol-2-one
  • 1-(1-(4,4-Bis(4-fluorophenyl)butyl)piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one
  • 1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • Neoperidole
  • 2H-Benzimidazol-2-one, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-
  • McN-JR 6238
  • 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
  • 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone
  • 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone
  • 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine
  • 1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
  • 2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-
  • Primozida
  • 3-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidyl]-1H-benzimidazol-2-one
  • Primozide
  • 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine
Show all 32 synonyms
  • 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one
  • Orap (TN)
  • Pimozide?
  • Pimozide CRS
  • 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one
  • Pimozide (Standard)
  • Tocris-0937

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
461.56 g/molcalc.
Exact mass
461.2279 Dacalc.
LogP (octanol/water)
5.86calc.
Topological polar surface area
41.03 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
7calc.
Heavy atoms
34calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.32calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccccc2)c2ccccc2)CC1

O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccccc2)c2ccccc2)CC1

5 rings, 32 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Pimozide suppliers

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All 77 suppliers
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Where suppliers are based

77 suppliers in 15 countries

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Pimozide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Dyskinesia Agents
  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • antidepressant
  • antidyskinesia agent
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Pimozide is a Typical Antipsychotic.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Pimozide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Pimozide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Pimozide, based on the data on this page

What is Pimozide?

Pimozide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group.

What is the CAS number of Pimozide?

The CAS registry number of Pimozide is 2062-78-4.

What is the molecular formula and weight of Pimozide?

The molecular formula of Pimozide is C28H29F2N3O and its molar mass is 461.56 g/mol.

What is Pimozide used for?

Use classes: Pharmaceuticals.

Is Pimozide hazardous?

Pimozide carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Pimozide?

Pimozide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Pimozide?

CompoundList lists 77 suppliers of Pimozide in United States, China, India, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Pimozide in India?

10 suppliers in India list Pimozide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Pimozide?

Suppliers quote Pimozide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Pimozide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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