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Peptides

Plitidepsin

Also known as Aplidine, aplidin, Dehydrodidemnin B

CAS 137219-37-5Formula C57H87N7O15Molar mass 1,110.36 g/mol
4 suppliers listed
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Plitidepsin chemical structure, C57H87N7O15, CAS 137219-37-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
137219-37-5
Formula
C57H87N7O15
Molar mass
1,110.36 g/mol
HS code
293499
Category
Peptides

What is Plitidepsin?

Plain description, key identifiers and synonyms

Plitidepsin is a didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans. It has a role as an anticoronaviral agent, an antineoplastic agent and a marine metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-N-[(2R)-1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-13-[(2S)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-N-methyl-1-(2-oxopropanoyl)pyrrolidine-2-carboxamide
CAS number
137219-37-5 CAS number cross-checked
Molecular formula
C57H87N7O15
UNII
Y76ID234HW
InChIKey
UUSZLLQJYRSZIS-LXNNNBEUSA-N
InChI
InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1
Canonical SMILES
CCC(C)C1NC(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)C2CCCN2C(=O)C(C)=O)C(C)OC(=O)C(Cc2ccc(OC)cc2)N(C)C(=O)C2CCCN2C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(C(C)C)OC(=O)CC1O
Isomeric SMILES
CC[C@H](C)[C@@H]1[C@H](CC(=O)O[C@H](C(=O)[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]3CCCN3C(=O)C(=O)C)C)CC4=CC=C(C=C4)OC)C)CC(C)C)C)C(C)C)O

Synonyms

  • Aplidine
  • aplidin
  • Dehydrodidemnin B
  • plitidepsina
  • plitidepsine
  • plitidepsinum
  • Dehydrodemnin B
  • N-(1-(1,2-Dioxopropyl)-L-prolyl)didemnin A
  • Plitidepsin (INN)
  • plitidepsium
  • Aplidine?
  • ZIY
  • Plitidepsin (Standard)
  • Didemnin A, N-(1-(1,2-dioxopropyl)-L-prolyl)-
  • 2-9-Didemnin B, 2-(1-(1,2-dioxopropyl)-L-proline)-
  • aplidine, dehydrodemnin B. US brand name: Aplidin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,110.36 g/molcalc.
Exact mass
1,109.626 Dacalc.
LogP (octanol/water)
2.52calc.
Topological polar surface area
284.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
15calc.
Rotatable bonds
15calc.
Heavy atoms
79calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.7calc.
Formal charge
0calc.
Stereocentres
12calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1COC(=O)CCCNC(=O)C(NC(=O)CNC(=O)C2CCCN2)COC(=O)C(Cc2ccccc2)NC(=O)C2CCCN2C(=O)CNC(=O)C1

O=C1COC(=O)CCCNC(=O)C(NC(=O)CNC(=O)C2CCCN2)COC(=O)C(Cc2ccccc2)NC(=O)C2CCCN2C(=O)CNC(=O)C1

4 rings, 52 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Plitidepsin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 1 country

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Plitidepsin price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anticoronaviral agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • marine metabolite
  • metabolite
  • pharmaceutical

Pharmacology

Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Plitidepsin is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Plitidepsin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Plitidepsin, based on the data on this page

What is Plitidepsin?

Plitidepsin is a didemnin that is didemin B in which the hydroxy group of the 1-(2-hydroxypropanoyl)-L-prolinamide moiety has been oxidised to the corresponding ketone. It was originally isolated from the Mediterranean tunicate Aplidium albicans.

What is the CAS number of Plitidepsin?

The CAS registry number of Plitidepsin is 137219-37-5.

What is the molecular formula and weight of Plitidepsin?

The molecular formula of Plitidepsin is C57H87N7O15 and its molar mass is 1,110.36 g/mol.

What is Plitidepsin used for?

Known uses and roles of Plitidepsin include anticoronaviral agent, antimicrobial agent, antineoplastic agent, antiviral agent, marine metabolite and 2 more.

Is Plitidepsin hazardous?

No GHS hazard classification for Plitidepsin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Plitidepsin?

Plitidepsin is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Plitidepsin?

CompoundList lists 4 suppliers of Plitidepsin in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Plitidepsin?

Suppliers quote Plitidepsin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Plitidepsin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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