Polymyxin B2
Also known as Polysporin (TN), Polymyxin B sulphate?
Key facts
What buyers check first
What is Polymyxin B2?
Plain description, key identifiers and synonyms
Polymyxin B2 is a polymyxin.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide
- CAS number
- 34503-87-2 CAS number cross-checked
- Molecular formula
- C55H96N16O13
- UNII
- 99SJO09VH2
- InChIKey
- SGPYLFWAQBAXCZ-RUDZPDEXSA-N
- InChI
- InChI=1S/C55H96N16O13/c1-30(2)12-10-11-15-43(74)62-35(16-22-56)50(79)71-45(33(6)73)55(84)67-38(19-25-59)47(76)66-40-21-27-61-54(83)44(32(5)72)70-51(80)39(20-26-60)64-46(75)36(17-23-57)65-52(81)41(28-31(3)4)68-53(82)42(29-34-13-8-7-9-14-34)69-48(77)37(18-24-58)63-49(40)78/h7-9,13-14,30-33,35-42,44-45,72-73H,10-12,15-29,56-60H2,1-6H3,(H,61,83)(H,62,74)(H,63,78)(H,64,75)(H,65,81)(H,66,76)(H,67,84)(H,68,82)(H,69,77)(H,70,80)(H,71,79)/t32-,33-,35+,36+,37+,38+,39+,40+,41+,42-,44+,45+/m1/s1
- Canonical SMILES
- CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O
- Isomeric SMILES
- C[C@H]([C@H]1C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCN)CCN)CC(C)C)CC2=CC=CC=C2)CCN)NC(=O)[C@H](CCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)CCCCC(C)C)O
Synonyms
- Polysporin (TN)
- Polymyxin B sulphate?
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 1,189.47 g/molcalc.Computed value |
|---|---|
| Exact mass | 1,188.7343 Dacalc.Computed value |
| LogP (octanol/water) | -5.63calc.Computed value |
| Topological polar surface area | 490.7 Ųcalc.Computed value |
| Hydrogen bond donors | 18calc.Computed value |
| Hydrogen bond acceptors | 18calc.Computed value |
| Rotatable bonds | 28calc.Computed value |
| Heavy atoms | 84calc.Computed value |
| Rings | 2calc.Computed value |
| Aromatic rings | 1calc.Computed value |
| Fraction sp3 carbons | 0.69calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 12calc.Computed value |
| Lipinski rule of five | Fails (3 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C1CCCNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)C(Cc2ccccc2)NC(=O)CN1
2 rings, 37 atoms.
33 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Polymyxin B2 suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- India, Ahmedabad ManufacturerUnclaimed profilePolymyxin B SulfateGrade, purity and minimum order on requestPrice on request
- Denmark, København S ManufacturerUnclaimed profilePolymyxin b sulfateGrade, purity and minimum order on requestPrice on request
- Nepal, NarayaniUnclaimed profilePolymyxin B SulphateGrade, purity and minimum order on requestPrice on request
- China, ChangzhouUnclaimed profilePolymyxin B sulfateGrade, purity and minimum order on requestPrice on request
- United StatesUnclaimed profilePolymyxin B sulfateGrade, purity and minimum order on requestPrice on request
- ChinaUnclaimed profilePolymyxin B SulfateGrade, purity and minimum order on requestPrice on request
- United StatesUnclaimed profilePolymyxin B SulfateGrade, purity and minimum order on requestPrice on request
- United StatesUnclaimed profilePolymyxin B SulfateGrade, purity and minimum order on requestPrice on request
- Price on request
- ChinaUnclaimed profilePolymyxin B SulfateGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
22 suppliers in 7 countries
- China10
- India4
- United States3
- Canada1
- Denmark1
- United Kingdom1
- and 1 more countries
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Polymyxin B2 price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Pharmacology
Polymyxin B2 is a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B2 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B2 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Polymyxin B2 is traded under.
Antibiotics, other
- China39.7%
- United States11.3%
- Switzerland * partner reported10.9%
* Partner reported figures, a lower bound.
The HS code shown for Polymyxin B2 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
![(6S)-N-[(2S)-4-Amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide, pentahydrochloride chemical structure, C56H103Cl5N16O13, CAS 6883-64-3](/s/OKIKKFVUTYOCNW-XNRVUXMISA-N.svg)
![(6S)-N-[(2S)-4-Amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide, sulfuric acid chemical structure, C56H108N16O33S5, CAS 1013028-95-9](/s/QMGBLVWWRQFHIE-XNRVUXMISA-N.svg)
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about Polymyxin B2, based on the data on this page
What is Polymyxin B2?
What is the CAS number of Polymyxin B2?
What is the molecular formula and weight of Polymyxin B2?
Is Polymyxin B2 hazardous?
What is the HS code of Polymyxin B2?
Where can I buy Polymyxin B2?
Where can I buy Polymyxin B2 in India?
What is the price of Polymyxin B2?
Guides for buyers
Practical guides that help when you source, ship or handle Polymyxin B2
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
- Guide, Chemical identityCAS registry numbers explainedWhat a CAS number identifies, how the check digit works, why one chemical can have several numbers and what a CAS number cannot tell you about a product.Read
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