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Prolylhydroxyproline

Also known as (2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid, (2S,4R)-4-hydroxy-1-(((2S)-pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carboxylic acid, (2S,4R)-4-hydroxy-1-((2S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid

CAS 18684-24-7Formula C10H16N2O4Molar mass 228.25 g/mol
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Prolylhydroxyproline chemical structure, C10H16N2O4, CAS 18684-24-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
18684-24-7
Formula
C10H16N2O4
Molar mass
228.25 g/mol
HS code
293399
Category
Peptides

What is Prolylhydroxyproline?

Plain description, key identifiers and synonyms

Pro-Hyp is a dipeptide composed of L-proline and L-hydroxyproline residues. It is a biomarker for bone collagen degradation. It has a role as a diagnostic agent, a biomarker and a human metabolite. It is functionally related to a L-proline and a trans-4-hydroxy-L-proline. It is a tautomer of a Pro-Hyp zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
CAS number
18684-24-7
Molecular formula
C10H16N2O4
UNII
W8TTC0Y1XY
MDL number
MFCD00037349
INCI name
DIPEPTIDE-6
InChIKey
ONPXCLZMBSJLSP-CSMHCCOUSA-N
InChI
InChI=1S/C10H16N2O4/c13-6-4-8(10(15)16)12(5-6)9(14)7-2-1-3-11-7/h6-8,11,13H,1-5H2,(H,15,16)/t6-,7+,8+/m1/s1
Canonical SMILES
O=C(O)C1CC(O)CN1C(=O)C1CCCN1
Isomeric SMILES
C1C[C@H](NC1)C(=O)N2C[C@@H](C[C@H]2C(=O)O)O

Synonyms

  • (2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
  • (2S,4R)-4-hydroxy-1-(((2S)-pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carboxylic acid
  • (2S,4R)-4-hydroxy-1-((2S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
  • (2S,4R)-4-hydroxy-1-{[(2S)-pyrrolidin-2-yl]carbonyl}pyrrolidine-2-carboxylic acid
  • (2S,4R)-4-hydroxy-1-((2S)-pyrrolidin-1-ium-2-carbonyl)pyrrolidine-2-carboxylate
  • (2S,4R)-4-hydroxy-1-[(2S)-pyrrolidin-1-ium-2-carbonyl]pyrrolidine-2-carboxylate
  • H-Pro-Hyp-OH
  • Pro-Hyp
  • Pro-Hyp-OH
  • L-Prolyl-L-hydroxyproline
  • (2S,4R)-1-(L-prolyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • (2S,4R)-4-hydroxy-1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
  • (2S,4R)-4-Hydroxy-1-[(2S)-2-pyrrolidinylcarbonyl]-2-pyrrolidinecarboxylic acid
  • (2S,4R)-4-Hydroxy-1-[(S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic Acid
  • 4-Hydroxy-1-L-prolyl-proline, 4-Hydroxy-1-L-prolyl-L-proline, L-Prolyl-L-hydroxyproline, Prolylhydroxyproline
  • proline-hydroxyproline
  • L-Pro-L-Hyp
  • L-Proline, L-prolyl-4-hydroxy-, (4R)-
  • 4-hydroxy-1-L-prolyl-Proline
  • (2S,4R)-4-hydroxy-1-
  • L-4-hydroxy-1-L-prolyl-Proline
  • trans-4-hydroxy-1-L-prolyl-Proline
  • (4R)-L-prolyl-4-hydroxy-L-Proline
  • L-prolyl-(4R)-4-hydroxy-L-proline
  • L-Prolyl-[(4R)-4-hydroxy-L-proline]
Show all 27 synonyms
  • 4-hydroxy-1-(2-pyrrolidinylcarbonyl)proline
  • Proline, 4-hydroxy-1-l-prolyl-, l-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
228.25 g/molcalc.
Exact mass
228.111 Dacalc.
LogP (octanol/water)
-1.22calc.
Topological polar surface area
89.87 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C1CCCN1)N1CCCC1

O=C(C1CCCN1)N1CCCC1

2 rings, 12 atoms, the Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone ring system.

164 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Prolylhydroxyproline suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Prolylhydroxyproline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name DIPEPTIDE-6(skin conditioning)

Roles

  • animal metabolite
  • biomarker
  • diagnostic agent
  • eukaryotic metabolite
  • human metabolite
  • indicator
  • mammalian metabolite
  • metabolite
  • pharmaceutical

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Prolylhydroxyproline is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Prolylhydroxyproline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Prolylhydroxyproline, based on the data on this page

What is Prolylhydroxyproline?

Pro-Hyp is a dipeptide composed of L-proline and L-hydroxyproline residues. It is a biomarker for bone collagen degradation. It has a role as a diagnostic agent, a biomarker and a human metabolite. It is functionally related to a L-proline and a trans-4-hydroxy-L-proline. It is a tautomer of a Pro-Hyp zwitterion.

What is the CAS number of Prolylhydroxyproline?

The CAS registry number of Prolylhydroxyproline is 18684-24-7.

What is the molecular formula and weight of Prolylhydroxyproline?

The molecular formula of Prolylhydroxyproline is C10H16N2O4 and its molar mass is 228.25 g/mol.

What is Prolylhydroxyproline used for?

Known uses and roles of Prolylhydroxyproline include skin conditioning agents in cosmetics and personal care, animal metabolite, biomarker, diagnostic agent, eukaryotic metabolite and 7 more.

Is Prolylhydroxyproline hazardous?

No GHS hazard classification for Prolylhydroxyproline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Prolylhydroxyproline?

Prolylhydroxyproline is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Prolylhydroxyproline?

CompoundList lists 2 suppliers of Prolylhydroxyproline in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Prolylhydroxyproline?

Suppliers quote Prolylhydroxyproline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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