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Central nervous system drugs

Propofol

Also known as 2,6-Diisopropylphenol, Diprivan, Disoprofol

CAS 2078-54-8Formula C12H18OMolar mass 178.28 g/molEC 218-206-6
GHS signal word: Warning. Pictograms: Harmful or irritant 115 suppliers listed Drug substance
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Propofol chemical structure, C12H18O, CAS 2078-54-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Light-straw-colored liquid
Melting point
18 °C
Boiling point
242 °C
Density
0.955 g/cm³ @ 20 °C
Solubility
Insoluble in water. Soluble in alcohol and toluene.
HS code
290719
Category
Central nervous system drugs
Illustrative photo, 200 litre blue HDPE drums of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Propofol?

Plain description, key identifiers and synonyms

Propofol is a phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. It has a role as an anticonvulsant, a sedative, an intravenous anaesthetic, a radical scavenger and an antiemetic.

Propofol is an intravenous medication used in anaesthesia.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2,6-di(propan-2-yl)phenol
CAS number
2078-54-8 CAS number cross-checkedOther or deprecated CAS: 113981-41-2
EC number
218-206-6
Molecular formula
C12H18O
UNII
YI7VU623SF
MDL number
MFCD00008885
InChIKey
OLBCVFGFOZPWHH-UHFFFAOYSA-N
InChI
InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
SMILES (canonical and isomeric)
CC(C)C1=C(C(=CC=C1)C(C)C)O

Synonyms

  • 2,6-Diisopropylphenol
  • Diprivan
  • Disoprofol
  • Disoprivan
  • Fresofol
  • Rapinovet
  • Ampofol
  • 2,6-Bis(1-methylethyl)phenol
  • Propofolum
  • Phenol, 2,6-bis(1-methylethyl)-
  • ICI 35868
  • Propovan
  • Propoven
  • Lipuro
  • 2,6 Diisopropylphenol
  • 2,6-bis(propan-2-yl)phenol
  • ICI 35,868
  • ICI35,868
  • Phenol, 2,6-bis(1-methylethyl)
  • ICI 35-868
  • Ketafol component propofol
  • 4-06-00-03435 (Beilstein Handbook Reference)
  • Propofol MCT
  • Rapanofal
  • PropoClear
Show all 38 synonyms
  • PropoFlo
  • Propofol Lipuro
  • Propovan CF
  • Propofol 1%
  • PropoFlo 28
  • PropofolVet Multidose
  • PropoFlo, PropoFlo 28
  • Propofol Injectable Emulsion
  • Diisopropylphenol
  • 2,6-di(propan-2-yl)phenol
  • Recofol
  • Ivofol
  • Propofol-Lipuro

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Light-straw-colored liquidexp.
Melting point
18 °Cexp.
Boiling point
242 °Cexp.
Density
0.955 g/cm³ @ 20 °Cexp.
Solubility
Insoluble in water. Soluble in alcohol and toluene.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
178.28 g/molcalc.
Exact mass
178.1358 Dacalc.
LogP (octanol/water)
3.64calc.
Topological polar surface area
20.23 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Propofol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 115 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

115 suppliers in 22 countries

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Propofol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industrial uses: Intermediate.

Use classes: Pharmaceuticals, Animal Drugs.

Industries and functions

Pharmacological actions

  • Anesthetics, Intravenous
  • Hypnotics and Sedatives

Roles

  • anaesthetic
  • analgesic
  • anti-arrhythmia drug
  • anti-inflammatory agent
  • anti-obesity agent
  • anticonvulsant
  • antidepressant
  • antiemetic
  • antihypertensive agent
  • antineoplastic agent
  • antiviral agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • general anaesthetic
  • hepatoprotective agent
  • intravenous anaesthetic
  • neuroprotective agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent
  • radical scavenger
  • sedative
  • vulnerary

Pharmacology

Propofol is a General Anesthetic. The physiologic effect of propofol is by means of General Anesthesia.

How it is made

B.E. Firth, T.J. Rosen, US 4447657 (1984 to Universal Oil Products).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Propofol is traded under.

HS 2907.19Indicative HS code

Monophenols, other

World exports in 2024
$671M
+2.2% vs 2023, imports $781M
2019 to 2024
Top exporters
  1. China20.1%
  2. Germany14.4%
  3. Switzerland * partner reported11.1%
Top importers
  1. China16.3%
  2. Germany10.1%
  3. South Korea8.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Propofol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Propofol, based on the data on this page

What is Propofol?

Propofol is a phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group. It has a role as an anticonvulsant, a sedative, an intravenous anaesthetic, a radical scavenger and an antiemetic.

What is the CAS number of Propofol?

The CAS registry number of Propofol is 2078-54-8. Other or deprecated CAS numbers: 113981-41-2.

What is the molecular formula and weight of Propofol?

The molecular formula of Propofol is C12H18O and its molar mass is 178.28 g/mol.

What is Propofol used for?

Industrial uses: Intermediate. Use classes: Pharmaceuticals, Animal Drugs.

Is Propofol hazardous?

Propofol carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Propofol?

Propofol is usually classified under HS code 290719 (Monophenols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Propofol?

CompoundList lists 115 suppliers of Propofol in China, United States, India, Germany and 18 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Propofol in India?

13 suppliers in India list Propofol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Propofol?

Suppliers quote Propofol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Propofol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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