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Antibiotics and anti-infectives

Psilocybin

Also known as Psilocybine, Indocybin, Psilocibin

CAS 520-52-5Formula C12H17N2O4PMolar mass 284.25 g/molEC 208-294-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade
Why it is not for trade
Psilocybin chemical structure, C12H17N2O4P, CAS 520-52-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from boiling water
Melting point
220 to 228
Solubility
Soluble in 20 parts boiling water
HS code
293399
Category
Antibiotics and anti-infectives

What is Psilocybin?

Plain description, key identifiers and synonyms

Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonancatl or "magic mushrooms"). It has a role as a hallucinogen, a serotonergic agonist, a prodrug and a fungal metabolite. It is an organic phosphate, a tryptamine alkaloid and a tertiary amino compound. It is functionally related to a psilocin. It is a conjugate acid of a psilocybin(1-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
CAS number
520-52-5 CAS number cross-checked
EC number
208-294-4
Molecular formula
C12H17N2O4P
UNII
2RV7212BP0
InChIKey
QVDSEJDULKLHCG-UHFFFAOYSA-N
InChI
InChI=1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17)
SMILES (canonical and isomeric)
CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O

Synonyms

  • Psilocybine
  • Indocybin
  • Psilocibin
  • Teonanacatl
  • Psilocin phosphate ester
  • Psilocibina
  • Psilotsibin
  • Psilocybinum
  • O-Phosphoryl-4-hydroxy-N,N-dimethyltryptamine
  • 4-Phosphoryloxy-N,N-dimethyltryptamine
  • 3-2'-Dimethylaminoethylindol-4-phosphate
  • 3-(2-(Dimethylamino)ethyl)-1H-indol-4-ol dihydrogen phosphate ester
  • 3-(2-Dimethylaminoethyl)indol-4-yl dihydrogen phosphate
  • COMP360
  • COMP-360
  • 4-Phosphoryloxy-omega-N,N-dimethyltryptamine
  • 3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate
  • 1H-Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate (ester)
  • [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
  • ({3-[2-(dimethylamino)ethyl]-1H-indol-4-yl}oxy)phosphonic acid
  • 3-(2-(dimethylamino)ethyl)-1H-indol-4-yl dihydrogen phosphate
  • ((3-(2-(dimethylamino)ethyl)-1H-indol-4-yl)oxy)phosphonic acid
  • (3-(2-(Dimethylamino)ethyl)-1H-indol-4-yl) dihydrogen phosphate
  • 1H-Indol-4-ol, 3-[2-(dimethylamino)ethyl]-, dihydrogen phosphate (ester)
  • (3-(2-(dimethylazaniumyl)ethyl)-1H-indol-4-yl) hydrogen phosphate
Show all 34 synonyms
  • Cy 39
  • Psilocybine (INN)
  • Psilocybin (USAN)
  • Psilocine Phosphate
  • Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate
  • Psylocybin
  • Psilocybin (1.0mg/ml in Methanol)
  • Psilocybin (1mg/ml in Acetonitrile)
  • Psilocybin (1mg/ml in 1:1 Acetonitrile:Water)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from boiling waterexp.
Taste
Slightly ammonia-likeexp.
Melting point
220 to 228exp.
Solubility
Soluble in 20 parts boiling waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
284.25 g/molcalc.
Exact mass
284.0926 Dacalc.
LogP (octanol/water)
1.74calc.
Topological polar surface area
85.79 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
5calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]ccc2c1

c1ccc2[nH]ccc2c1

2 rings, 9 atoms, the Indole ring system.

25,097 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H302Harmful if swallowed.
  • H310Fatal in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H330Fatal if inhaled.
  • H370Causes damage to organs.
Precautionary statements (25)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Psilocybin suppliers

Trading restrictions apply to this substance

Psychotropic substance

Psilocybin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971 Schedule I

Our policy on controlled substances

Psilocybin price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Hallucinogens.

The use of hallucinogenic mushrooms predates the arrival of the Spaniards to the New World. The Aztecs consumed a substance called teonanacatl (God's flesh) in religious ceremonies. Later, Psilocybe mexicana was discovered to be the active component of teonanacatl. The use of mushrooms by people native to the Americas to produce mystical revelations during religious ceremonies continued into the twentieth century.

Pharmacological actions

  • Hallucinogens

Roles

  • analgesic
  • antibacterial drug
  • antidepressant
  • antiinfective agent
  • antimicrobial drug
  • antineoplastic agent
  • antipsychotic agent
  • anxiolytic drug
  • appetite enhancer
  • appetite regulator
  • central nervous system depressant
  • central nervous system drug
  • fungal metabolite
  • geroprotector
  • hallucinogen
  • neurotransmitter agent
  • pharmaceutical
  • pro-agent
  • prodrug
  • protective agent
  • psychotropic drug
  • serotonergic agonist
  • serotonergic drug
  • vulnerary

Pharmacology

Psilocybine is a tryptamine alkaloid, isolated from various genera of fungi including the genus Psilocybe, with hallucinogenic, anxiolytic, and psychoactive activities. In vivo, psilocybine is rapidly dephosphorylated into the active compound psilocin, which activates serotonin 2A (5-HT2A) receptors in the central nervous system (CNS), mimicking the effects of serotonin.

How it is made

Heim et al., DE 1087321(1960 to Sandoz)

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Psilocybin is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971 Schedule I

Our policy on controlled substances

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Psilocybine (INN), Ref no: 278, Annex ref: II/278

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Psilocybin is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Psilocybin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Psilocybin, based on the data on this page

What is Psilocybin?

Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonancatl or "magic mushrooms").

What is the CAS number of Psilocybin?

The CAS registry number of Psilocybin is 520-52-5.

What is the molecular formula and weight of Psilocybin?

The molecular formula of Psilocybin is C12H17N2O4P and its molar mass is 284.25 g/mol.

What is Psilocybin used for?

Hallucinogens. The use of hallucinogenic mushrooms predates the arrival of the Spaniards to the New World. The Aztecs consumed a substance called teonanacatl (God's flesh) in religious ceremonies. Later, Psilocybe mexicana was discovered to be the active component of teonanacatl.

Is Psilocybin hazardous?

Psilocybin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, harmful if swallowed, fatal in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Psilocybin?

Psilocybin is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Can I buy Psilocybin on CompoundList?

No. Psilocybin is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Psilocybin

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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