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Screening compounds

Puquitinib

Also known as XC-302 free base, 9H-Purine-2,6-diamine, N6-cyclopropyl-N2-6-quinolinyl-, N'-cyclopropyl-N-quinolin-6-yl-7H-purine-2,6-diamine

CAS 916890-10-3Formula C17H15N7Molar mass 317.36 g/mol
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Puquitinib chemical structure, C17H15N7, CAS 916890-10-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
916890-10-3
Formula
C17H15N7
Molar mass
317.36 g/mol
HS code
293359
Category
Screening compounds

What is Puquitinib?

Plain description, key identifiers and synonyms

Puquitinib is an orally available selective inhibitor of the delta form of phosphatidylinositol 3-kinase (PI3-kinase subunit delta, PI3K-delta, PI3Kdelta), with potential antineoplastic activity. Upon oral administration, puquitinib selectively binds to the ATP-binding pocket of PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K-delta over-expressing tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-N-cyclopropyl-2-N-quinolin-6-yl-7H-purine-2,6-diamine
CAS number
916890-10-3
Molecular formula
C17H15N7
UNII
WFG29AB872
InChIKey
QUTFBURLXCODBH-UHFFFAOYSA-N
InChI
InChI=1S/C17H15N7/c1-2-10-8-12(5-6-13(10)18-7-1)22-17-23-15-14(19-9-20-15)16(24-17)21-11-3-4-11/h1-2,5-9,11H,3-4H2,(H3,19,20,21,22,23,24)
SMILES (canonical and isomeric)
C1CC1NC2=NC(=NC3=C2NC=N3)NC4=CC5=C(C=C4)N=CC=C5

Synonyms

  • XC-302 free base
  • 9H-Purine-2,6-diamine, N6-cyclopropyl-N2-6-quinolinyl-
  • N'-cyclopropyl-N-quinolin-6-yl-7H-purine-2,6-diamine
  • Puquitinib dimesylate dihydrate
  • 6-N-cyclopropyl-2-N-quinolin-6-yl-7H-purine-2,6-diamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
317.36 g/molcalc.
Exact mass
317.1389 Dacalc.
LogP (octanol/water)
3.22calc.
Topological polar surface area
91.41 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.18calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnc2ccc(Nc3nc(NC4CC4)c4[nH]cnc4n3)cc2c1

c1cnc2ccc(Nc3nc(NC4CC4)c4[nH]cnc4n3)cc2c1

5 rings, 24 atoms. This chemical is the scaffold itself.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Puquitinib suppliers

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Puquitinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Puquitinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Puquitinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Puquitinib, based on the data on this page

What is Puquitinib?

Puquitinib is an orally available selective inhibitor of the delta form of phosphatidylinositol 3-kinase (PI3-kinase subunit delta, PI3K-delta, PI3Kdelta), with potential antineoplastic activity.

What is the CAS number of Puquitinib?

The CAS registry number of Puquitinib is 916890-10-3.

What is the molecular formula and weight of Puquitinib?

The molecular formula of Puquitinib is C17H15N7 and its molar mass is 317.36 g/mol.

What is Puquitinib used for?

Known uses and roles of Puquitinib include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Puquitinib hazardous?

No GHS hazard classification for Puquitinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Puquitinib?

Puquitinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Puquitinib?

Post a free request on CompoundList and suppliers of Puquitinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Puquitinib?

Suppliers quote Puquitinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Puquitinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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