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Analgesics and anti-inflammatories

Quinine

Also known as Chinine, Chinin, (-)-Quinine

CAS 130-95-0Formula C20H24N2O2Molar mass 324.42 g/molEC 205-003-2
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 82 suppliers listed Drug substance
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Quinine chemical structure, C20H24N2O2, CAS 130-95-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Triboluminescent, orthorhombic needles from absolute alcohol
Melting point
177 °C
Solubility
In water, 500 mg/L at 15 °C
HS code
293920
Category
Analgesics and anti-inflammatories
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Quinine?

Plain description, key identifiers and synonyms

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as a non-narcotic analgesic, an antimalarial and a muscle relaxant. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
CAS number
130-95-0 CAS number cross-checkedOther or deprecated CAS: 72402-53-0
EC numbers
205-003-2, 215-805-4
Molecular formula
C20H24N2O2
UNII
26MX5YAL2R, A7V27PHC7A
MDL number
MFCD00198096
INCI name
QUININE
InChIKey
LOUPRKONTZGTKE-WZBLMQSHSA-N
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
Canonical SMILES
C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12
Isomeric SMILES
COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O

Synonyms

  • Chinine
  • Chinin
  • (-)-Quinine
  • (8S,9R)-Quinine
  • 6'-Methoxycinchonidine
  • (R)-(-)-quinine
  • 6-Methoxycinchonine
  • chininum
  • quinina
  • Rezquin
  • Chininum purum
  • (8S,9R)-6'-Methoxycinchonan-9-ol
  • (R)-(-)-Quinine, 6-methoxycinchonidine
  • (8-alpha,9R)-6'-Methoxycinchonan-9-ol
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
  • (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol
  • 2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-
  • (R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
  • Quinson
  • Quinsul
  • (R)-((1S,2S,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)(6-methoxyquinolin-4-yl)methanol
  • (R)-((2S,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
  • (R)-((4S,5R,7S)-5-ethenyl-1-azabicyclo(2.2.2)octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
  • (R)-[(4S,5R,7S)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
  • Hydrochloride, Quinine
Show all 37 synonyms
  • Quinoline alkaloid
  • Quinine, Anhydrous
  • Quinsan
  • Quinine anhydrous
  • quinine bisulphate
  • Aflukin
  • (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • GNF-Pf-506
  • (9R)-6'-methoxy-8alpha-cinchonan-9-ol
  • Quinine, tannate
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
  • (-)quinine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Triboluminescent, orthorhombic needles from absolute alcoholexp.
Odour
ODORLESSexp.
Taste
Very bitter tasteexp.
Melting point
177 °Cexp.
Solubility
In water, 500 mg/L at 15 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
324.42 g/molcalc.
Exact mass
324.1838 Dacalc.
LogP (octanol/water)
3.17calc.
Topological polar surface area
45.59 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.45calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(CC3CC4CCN3CC4)ccnc2c1

c1ccc2c(CC3CC4CCN3CC4)ccnc2c1

5 rings, 19 atoms.

518 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (23)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Quinine suppliers

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All 82 suppliers
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Where suppliers are based

82 suppliers in 16 countries

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Quinine price

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Uses and applications

What the substance is used for, by industry and function

Medicine (antimalarial) as the alkaloid or as numerous salts and derivatives, flavoring in carbonated beverages.

Flavor in carbonated beverages.

Veterinary medication:.

Use classes: Cosmetics, Pharmaceuticals.

Cosmetic ingredient, INCI name QUININE(denaturant, hair conditioning, fragrance)

Pharmacological actions

  • Analgesics, Non-Narcotic
  • Antimalarials
  • Muscle Relaxants, Central

Roles

  • analgesic
  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • muscle relaxant
  • neuromuscular agent
  • non-narcotic analgesic
  • pharmaceutical

Functional uses

  • Deodorizer
  • Pharmaceutical
  • Softener and conditioner

Cosmetic functions

  • Denaturant
  • Fragrance
  • Hair conditioning

Pharmacology

Quinine is an Antimalarial.

How it is made

Extraction from cinchona bark with slaked lime, followed by aq sodium hydroxide or carbonate treatment, extraction into hot mineral oil, sepn using sulfuric acid, then dil sodium hydroxide, & purification by recrystallization

Finely ground cinchona bark mixed with lime is extracted with hot, high-boiling paraffin oil. The solution is filtered, shaken with dilute sulfuric acid, and the latter neutralized while still hot with sodium carbonate, on cooling, quinine sulfate crystallized out. The sulfate is then treated with ammonia, the alkaloid being obtained.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: QUININE, Ref no: 21, Annex ref: III/21
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Quinine is traded under.

HS 2939.20Indicative HS code

Alkaloids of cinchona and their derivatives, salts thereof

World exports in 2024
$33.5M
+7.5% vs 2023, imports $36.7M
2019 to 2024
Top exporters
  1. Netherlands30.5%
  2. Indonesia23.9%
  3. Madagascar * partner reported22.2%
Top importers
  1. Netherlands21.2%
  2. United States13.7%
  3. Ireland9.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Quinine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Quinine, based on the data on this page

What is Quinine?

Quinine is a cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy. It has a role as a non-narcotic analgesic, an antimalarial and a muscle relaxant. It is a conjugate base of a quinine(1+). It derives from a hydride of an (8S)-cinchonan.

What is the CAS number of Quinine?

The CAS registry number of Quinine is 130-95-0. Other or deprecated CAS numbers: 72402-53-0.

What is the molecular formula and weight of Quinine?

The molecular formula of Quinine is C20H24N2O2 and its molar mass is 324.42 g/mol.

What is Quinine used for?

Medicine (antimalarial) as the alkaloid or as numerous salts and derivatives, flavoring in carbonated beverages. Flavor in carbonated beverages. Veterinary medication:. Use classes: Cosmetics, Pharmaceuticals.

Is Quinine hazardous?

Quinine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Quinine?

Quinine is usually classified under HS code 293920 (Alkaloids of cinchona and their derivatives, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Quinine?

CompoundList lists 82 suppliers of Quinine in United States, China, Germany, Spain and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Quinine in India?

2 suppliers in India list Quinine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Quinine?

Suppliers quote Quinine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Quinine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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