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Antibiotics and anti-infectives

Quinidine

Also known as (+)-Quinidine, Conquinine, Pitayine

CAS 56-54-2Formula C20H24N2O2Molar mass 324.42 g/molEC 200-279-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 70 suppliers listed Drug substance
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Quinidine chemical structure, C20H24N2O2, CAS 56-54-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals with 2.5 mol water of crystallization, crystals from dilute alcohol
Melting point
174 to 175
Solubility
Lustrous needles, decomposes at 259 °C (drug), specific optical rotation at 20 °C/D + 20…
HS code
293920
Category
Antibiotics and anti-infectives
UN number
UN 2811
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Quinidine?

Plain description, key identifiers and synonyms

Quinidine is a cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. It has a role as an alpha-adrenergic antagonist, an antimalarial, an anti-arrhythmia drug, a sodium channel blocker, a muscarinic antagonist, a P450 inhibitor, a potassium channel blocker, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor, an EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor and a drug allergen. It derives from a hydride of a cinchonan.

Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
CAS number
56-54-2 CAS number cross-checked
EC number
200-279-0
Molecular formula
C20H24N2O2
UNII
ITX08688JL
MDL number
MFCD00135581
InChIKey
LOUPRKONTZGTKE-LHHVKLHASA-N
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
Canonical SMILES
C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12
Isomeric SMILES
COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O

Synonyms

  • (+)-Quinidine
  • Conquinine
  • Pitayine
  • (9S)-6'-Methoxycinchonan-9-ol
  • (8R,9S)-Quinidine
  • Conchinin
  • Quinidex
  • Chinidin
  • beta-Quinine
  • Conchinine
  • Kinidin
  • beta-Quinidine
  • Quiniduran
  • Cinchonan-9-ol, 6'-methoxy-, (9S)-
  • alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
  • (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
  • 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
  • alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-
  • (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
  • (R)-(6-methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol
  • (S)-[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
  • Apo Quinidine
  • (S)-(6-methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol
  • (S)-((2R,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
  • (S)-((4S,5R,7R)-5-ethenyl-1-azabicyclo(2.2.2)octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
Show all 36 synonyms
  • (S)-((2R,4S,5R)-5-ethenyl-1-azabicyclo(2.2.2)octan-2-yl)(6-methoxyquinolin-4-yl)methanol
  • (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo(2.2.2)oct-2-yl)-methanol
  • (S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
  • Quinicardine
  • Quinindine
  • Chinidine
  • (1S)-(6-Methoxyquinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • Quinora
  • (S)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • Quinidine (>85%)
  • (3'alpha, 9S)-6'-Methoxycinchonan-9-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals with 2.5 mol water of crystallization, crystals from dilute alcoholexp.
Melting point
174 to 175exp.
Solubility
Lustrous needles, decomposes at 259 °C (drug), specific optical rotation at 20 °C/D + 200 deg, sol in 60 parts water, freely soluble in hot water, in alcohol, chloroform, slightly in ether, neutral reaction. /Quinidine hydrochloride…exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
324.42 g/molcalc.
Exact mass
324.1838 Dacalc.
LogP (octanol/water)
3.17calc.
Topological polar surface area
45.59 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.45calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(CC3CC4CCN3CC4)ccnc2c1

c1ccc2c(CC3CC4CCN3CC4)ccnc2c1

5 rings, 19 atoms.

518 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Quinidine suppliers

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All 70 suppliers
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Where suppliers are based

70 suppliers in 16 countries

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Quinidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-Antagonists
  • Anti-Arrhythmia Agents
  • Antimalarials
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Enzyme Inhibitors
  • Muscarinic Antagonists
  • Voltage-Gated Sodium Channel Blockers

Roles

  • P450 inhibitor
  • adrenergic agent
  • adrenergic antagonist
  • aetiopathogenetic role
  • alpha-adrenergic antagonist
  • alpha-adrenergic drug
  • anti-arrhythmia drug
  • antiinfective agent
  • antimalarial
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • biophysical role
  • cardiovascular drug
  • cholinergic antagonist
  • cholinergic drug
  • drug allergen
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical
  • potassium channel blocker
  • sodium channel blocker

Pharmacology

Quinidine is an Antiarrhythmic and Cytochrome P450 2D6 Inhibitor. The mechanism of action of quinidine is as a Cytochrome P450 2D6 Inhibitor.

How it is made

Isomerization of quinine sulfate

Quinidine may be made by treating quinine with a metallic alkoxide or by oxidizing quinine to quinone and then reducing the latter with sodium isopropoxide. It may also be obtained directly from the mother liquors remaining after removal of quinine from extracts of Cinchona, separation from cinchonine and other alkaloids is effected by special processes

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Quinidine is traded under.

HS 2939.20Indicative HS code

Alkaloids of cinchona and their derivatives, salts thereof

World exports in 2024
$33.5M
+7.5% vs 2023, imports $36.7M
2019 to 2024
Top exporters
  1. Netherlands30.5%
  2. Indonesia23.9%
  3. Madagascar * partner reported22.2%
Top importers
  1. Netherlands21.2%
  2. United States13.7%
  3. Ireland9.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Quinidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Quinidine, based on the data on this page

What is Quinidine?

Quinidine is a cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.

What is the CAS number of Quinidine?

The CAS registry number of Quinidine is 56-54-2.

What is the molecular formula and weight of Quinidine?

The molecular formula of Quinidine is C20H24N2O2 and its molar mass is 324.42 g/mol.

What is Quinidine used for?

Use classes: Pharmaceuticals.

Is Quinidine hazardous?

Quinidine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Quinidine?

Quinidine is usually classified under HS code 293920 (Alkaloids of cinchona and their derivatives, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Quinidine?

CompoundList lists 70 suppliers of Quinidine in United States, China, Germany, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Quinidine in India?

2 suppliers in India list Quinidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Quinidine?

Suppliers quote Quinidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Quinidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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