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Impurities and reference standards

(R)-9-Hydroxy risperidone

Also known as (R)-paliperidone, (+)-9-Hydroxyrisperidone, Paliperidone R-Isomer

CAS 130049-85-3Formula C23H27FN4O3Molar mass 426.49 g/mol
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(R)-9-Hydroxy risperidone chemical structure, C23H27FN4O3, CAS 130049-85-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
130049-85-3
Formula
C23H27FN4O3
Molar mass
426.49 g/mol
HS code
293499
Category
Impurities and reference standards

What is (R)-9-Hydroxy risperidone?

Plain description, key identifiers and synonyms

(R)-paliperidone is a 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (R)-enantiomer of paliperidone. It is an enantiomer of a (S)-paliperidone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
CAS number
130049-85-3
Molecular formula
C23H27FN4O3
UNII
29F930S8Z1
InChIKey
PMXMIIMHBWHSKN-LJQANCHMSA-N
InChI
InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/t19-/m1/s1
Canonical SMILES
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O
Isomeric SMILES
CC1=C(C(=O)N2CCC[C@H](C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

Synonyms

  • (R)-paliperidone
  • (+)-9-Hydroxyrisperidone
  • Paliperidone R-Isomer
  • Paliperidone, (R)-
  • (9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • 9-hydroxy risperidone
  • (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • (9R)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one
  • (R)-3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
  • 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-, (9R)-
  • 9-(R)-Paliperidone
  • 9R-Paliperidone
  • Paliperidone (Invega)
  • Risperidone EP Impurity C
  • (9R)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4 -one
  • (9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidyl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • (9R)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
426.49 g/molcalc.
Exact mass
426.2067 Dacalc.
LogP (octanol/water)
3.08calc.
Topological polar surface area
84.39 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
31calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(CCN2CCC(c3noc4ccccc34)CC2)cnc2n1CCCC2

O=c1c(CCN2CCC(c3noc4ccccc34)CC2)cnc2n1CCCC2

5 rings, 28 atoms.

43 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(R)-9-Hydroxy risperidone suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 2 countries

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(R)-9-Hydroxy risperidone price

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (R)-9-Hydroxy risperidone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for (R)-9-Hydroxy risperidone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (R)-9-Hydroxy risperidone, based on the data on this page

What is (R)-9-Hydroxy risperidone?

(R)-paliperidone is a 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one that is the (R)-enantiomer of paliperidone. It is an enantiomer of a (S)-paliperidone.

What is the CAS number of (R)-9-Hydroxy risperidone?

The CAS registry number of (R)-9-Hydroxy risperidone is 130049-85-3.

What is the molecular formula and weight of (R)-9-Hydroxy risperidone?

The molecular formula of (R)-9-Hydroxy risperidone is C23H27FN4O3 and its molar mass is 426.49 g/mol.

What is (R)-9-Hydroxy risperidone used for?

Use classes: Pharmaceuticals.

Is (R)-9-Hydroxy risperidone hazardous?

No GHS hazard classification for (R)-9-Hydroxy risperidone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (R)-9-Hydroxy risperidone?

(R)-9-Hydroxy risperidone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (R)-9-Hydroxy risperidone?

CompoundList lists 2 suppliers of (R)-9-Hydroxy risperidone in China and Czech Republic. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (R)-9-Hydroxy risperidone?

Suppliers quote (R)-9-Hydroxy risperidone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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