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Central nervous system drugs

Risperidone

Also known as Risperdal, Risperdal Consta, Rispolept

CAS 106266-06-2Formula C23H27FN4O2Molar mass 410.49 g/molEC 600-733-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard, Hazardous to the environment 182 suppliers listed Drug substance
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Risperidone chemical structure, C23H27FN4O2, CAS 106266-06-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to slightly beige powder
Melting point
170 °C
Solubility
Soluble in methylene chloride, sparingly soluble in alcohol, practically insoluble in wa…
HS code
293499
Category
Central nervous system drugs
Illustrative photo, fine white powder in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Risperidone?

Plain description, key identifiers and synonyms

Risperidone is a member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. It has a role as a psychotropic drug, an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist, a dopaminergic antagonist, a second generation antipsychotic and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is an organofluorine compound, a pyridopyrimidine, a heteroarylpiperidine and a member of 1,2-benzoxazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
CAS number
106266-06-2 CAS number cross-checkedOther or deprecated CAS: 1026102-43-1
EC number
600-733-1
Molecular formula
C23H27FN4O2
UNII
L6UH7ZF8HC
MDL number
MFCD00274576
InChIKey
RAPZEAPATHNIPO-UHFFFAOYSA-N
InChI
InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
SMILES (canonical and isomeric)
CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

Synonyms

  • Risperdal
  • Risperdal Consta
  • Rispolept
  • Rispolin
  • Risperin
  • Sequinan
  • Risperidona
  • Risperidal M-Tab
  • Risperidonum
  • Risperdal M-Tab
  • Spiron
  • Perseris
  • Risvan
  • Rykindo
  • UZEDY
  • 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-
  • Consta, Risperdal
  • 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
  • 4H-Pyrido(1,2-a)pyrimidin-4-one, 6,7,8,9-tetrahydro-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-2-methyl-
  • 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-
  • 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
  • Risperdal M
  • Risperdal quicklet
  • Risperidone M-tab
  • 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-4-one
Show all 38 synonyms
  • 3-(2-(4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4H,6H,7H,8H,9H-pyrido(1,2-a)pyrimidin-4-one
  • 3-(2-(4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydropyrido(2,1-b)pyrimidin-4-one
  • 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
  • 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[2,1-b]pyrimidin-4-one
  • Perseris kit
  • Risperdal Consta Long Acting
  • Rykindo extended-release microspheres
  • Apexidone
  • Belivon
  • Psychodal
  • 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to slightly beige powderexp.
Melting point
170 °Cexp.
Solubility
Soluble in methylene chloride, sparingly soluble in alcohol, practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
410.49 g/molcalc.
Exact mass
410.2118 Dacalc.
LogP (octanol/water)
3.59calc.
Topological polar surface area
64.16 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
30calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c(CCN2CCC(c3noc4ccccc34)CC2)cnc2n1CCCC2

O=c1c(CCN2CCC(c3noc4ccccc34)CC2)cnc2n1CCCC2

5 rings, 28 atoms.

43 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H331Toxic if inhaled.
  • H351Suspected of causing cancer.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Risperidone suppliers

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All 182 suppliers
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Where suppliers are based

182 suppliers in 31 countries

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Risperidone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antipsychotic Agents, Dopamine Antagonists, Serotonin Antagonists.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antipsychotic Agents
  • Dopamine Antagonists
  • Serotonin Antagonists

Roles

  • H1-receptor antagonist
  • adrenergic agent
  • adrenergic antagonist
  • alpha-adrenergic antagonist
  • alpha-adrenergic drug
  • antagonist
  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • enzyme inhibitor
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • second generation antipsychotic
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Risperidone is an Atypical Antipsychotic.

How it is made

A Friedel-Crafts condensation of 1-acetylpiperidone-4-carbonyl chloride and 2,4-difluorobenzene, followed by hydrolysis of the N-acetyl group yields 4-(2,4-difluorobenzoyl)piperidone and the benzoyl carbonyl is converted to the oxime. With alkali, the fluorine atom in the 2-position is displaced through ring closure to form the isoxazole moiety. The secondary amine of the piperidine ring is alkylated with 3-(2-chloroethyl)pyridol[1,2-a]pyrimidin-4-one to yield the product.

Preparation: L. E. J. Kennis, J. Vandenberk, European Patent Office 196132, eidem, United States of America patent 4804663 (1986, 1989 both to Janssen)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Risperidone is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Risperidone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Risperidone, based on the data on this page

What is Risperidone?

Risperidone is a member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.

What is the CAS number of Risperidone?

The CAS registry number of Risperidone is 106266-06-2. Other or deprecated CAS numbers: 1026102-43-1.

What is the molecular formula and weight of Risperidone?

The molecular formula of Risperidone is C23H27FN4O2 and its molar mass is 410.49 g/mol.

What is Risperidone used for?

Antipsychotic Agents, Dopamine Antagonists, Serotonin Antagonists. Use classes: Pharmaceuticals.

Is Risperidone hazardous?

Risperidone carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic if inhaled, suspected of causing cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Risperidone?

Risperidone is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Risperidone?

CompoundList lists 182 suppliers of Risperidone in China, United States, India, Germany and 27 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Risperidone in India?

34 suppliers in India list Risperidone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Risperidone?

Suppliers quote Risperidone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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