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Impurities and reference standards

Ramelteon

Also known as Rozerem, (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide, n-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}propanamide

CAS 196597-26-9Formula C16H21NO2Molar mass 259.35 g/molEC 688-929-3
GHS signal word: Warning. Pictograms: Harmful or irritant 89 suppliers listed Drug substance
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Ramelteon chemical structure, C16H21NO2, CAS 196597-26-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
196597-26-9
Formula
C16H21NO2
Appearance
Crystals from ethyl acetate
Melting point
113 to 115
HS code
293299
Category
Impurities and reference standards
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Ramelteon?

Plain description, key identifiers and synonyms

N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e]benzofuran-8-yl]ethyl]propanamide is a member of indanes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
CAS number
196597-26-9 CAS number cross-checked
EC numbers
688-929-3, 690-982-2
Molecular formula
C16H21NO2
UNII
901AS54I69
MDL number
MFCD08067736
InChIKey
YLXDSYKOBKBWJQ-LBPRGKRZSA-N
InChI
InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1
Canonical SMILES
CCC(=O)NCCC1CCc2ccc3c(c21)CCO3
Isomeric SMILES
CCC(=O)NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3

Synonyms

  • Rozerem
  • (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide
  • n-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}propanamide
  • Propanamide, N-(2-((8S)-1,6,7,8-tetrahydro-2H-indeno(5,4-b)furan-8-yl)ethyl)-
  • ramelteonum
  • N-(2-((8S)-1H,2H,6H,7H,8H-indeno(5,4-b)furan-8-yl)ethyl)propanamide
  • N-(2-((8S)-2,6,7,8-tetrahydro-1H-cyclopenta(e)(1)benzoxol-8-yl)ethyl)propanamide
  • N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzoxol-8-yl]ethyl]propanamide
  • (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide
  • (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl)propionamide
  • N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
  • (S)-N-(2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethyl)propionamide
  • N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
  • N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide
  • N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e]benzofuran-8-yl]ethyl]propanamide
  • Rozerem (TN)
  • Ramelteon (JAN/USAN/INN)
  • (S)-N-(2-[1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl)propionamide
  • (S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide
  • JEV
  • Ramelteon (Standard)
  • Ramelteon Impurity 72
  • Ramelteon (TAK-375)
  • Ramelteon 1.0 mg/ml in Acetonitrile
  • (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl)propanamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethyl acetateexp.
Melting point
113 to 115exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
259.35 g/molcalc.
Exact mass
259.1572 Dacalc.
LogP (octanol/water)
2.57calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.56calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c(c3c1CCC3)CCO2

c1cc2c(c3c1CCC3)CCO2

3 rings, 12 atoms.

37 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ramelteon suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 89 suppliers
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Where suppliers are based

89 suppliers in 15 countries

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Ramelteon price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Treatment of insomnia characterized by difficulty with sleep onset.

Therapeutic category: Sedative, hypnotic.

Roles

  • antidepressant
  • antimicrobial agent
  • antipsychotic agent
  • antiviral agent
  • central nervous system depressant
  • central nervous system drug
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Ramelteon is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ramelteon is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ramelteon is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ramelteon, based on the data on this page

What is Ramelteon?

N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e]benzofuran-8-yl]ethyl]propanamide is a member of indanes.

What is the CAS number of Ramelteon?

The CAS registry number of Ramelteon is 196597-26-9.

What is the molecular formula and weight of Ramelteon?

The molecular formula of Ramelteon is C16H21NO2 and its molar mass is 259.35 g/mol.

What is Ramelteon used for?

Treatment of insomnia characterized by difficulty with sleep onset. Therapeutic category: Sedative, hypnotic.

Is Ramelteon hazardous?

Ramelteon carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ramelteon?

Ramelteon is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ramelteon?

CompoundList lists 89 suppliers of Ramelteon in China, United States, India, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ramelteon in India?

8 suppliers in India list Ramelteon on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ramelteon?

Suppliers quote Ramelteon on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ramelteon

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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