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Aromatic building blocks

Nortilidine

Also known as 3-Cyclohexene-1-carboxylic acid, 2-(methylamino)-1-phenyl-, ethyl ester, (1R,2S)-rel-, ethyl (1R,2S)-2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate, (-)-nortilidine

CAS 38677-94-0Formula C16H21NO2Molar mass 259.35 g/mol
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Nortilidine chemical structure, C16H21NO2, CAS 38677-94-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
38677-94-0
Formula
C16H21NO2
Molar mass
259.35 g/mol
HS code
292249
Category
Aromatic building blocks

What is Nortilidine?

Plain description, key identifiers and synonyms

(1R,2S)-nortilidine is an ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate that is ent-dextilidine in which one of the methyl groups attached to the nitrogen is replaced by hydrogen. ent-Dextilidine is metabolised to (1R,2S)-nortilidine by the liver. It has a role as a drug metabolite and a NMDA receptor antagonist. It is an enantiomer of a (1S,2R)-nortilidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl (1R,2S)-2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate
CAS number
38677-94-0 CAS number cross-checked
Molecular formula
C16H21NO2
UNII
7145G6817J
InChIKey
PDJZPNKVLDWEKI-GOEBONIOSA-N
InChI
InChI=1S/C16H21NO2/c1-3-19-15(18)16(13-9-5-4-6-10-13)12-8-7-11-14(16)17-2/h4-7,9-11,14,17H,3,8,12H2,1-2H3/t14-,16+/m0/s1
SMILES
CCOC(=O)[C@]1(CCC=C[C@@H]1NC)C2=CC=CC=C2

Synonyms

  • 3-Cyclohexene-1-carboxylic acid, 2-(methylamino)-1-phenyl-, ethyl ester, (1R,2S)-rel-
  • ethyl (1R,2S)-2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate
  • (-)-nortilidine
  • (1R,2S)-nortilidine
  • (1R,2S)-(-)-nortilidine
  • 1-Phenyl-1-trans-carbethoxy-2-methylaminocyclohex-3-ene
  • ethyl trans-(-)-2-(methylamino)-1-phenyl-3-cyclohexene-1-carboxylate
  • 3-Cyclohexene-1-carboxylic acid, 2-(methylamino)-1-phenyl-, ethyl ester, trans-
  • 3-Cyclohexene-1-carboxylic acid, 2-(methylamino)-1-phenyl-, ethyl ester, trans-(+-)-
  • Ethyl (1R,6S)-6-(methylamino)-3,6-dihydro[1,1'-biphenyl]-1(2H)-carboxylate
  • 3-Cyclohexene-1-carboxylic acid, 2-(methylamino)-1-phenyl-, ethyl ester, trans-(+/-)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
259.35 g/molcalc.
Exact mass
259.1572 Dacalc.
LogP (octanol/water)
2.43calc.
Topological polar surface area
38.33 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CCC(c2ccccc2)CC1

C1=CCC(c2ccccc2)CC1

2 rings, 12 atoms, the 4-Phenylcyclohexene ring system.

93 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Nortilidine suppliers

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Nortilidine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • NMDA receptor antagonist
  • animal metabolite
  • antagonist
  • drug metabolite
  • eukaryotic metabolite
  • excitatory amino acid antagonist
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • xenobiotic metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nortilidine is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, and…

World exports in 2024
$3.88B
−11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nortilidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nortilidine, based on the data on this page

What is Nortilidine?

(1R,2S)-nortilidine is an ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate that is ent-dextilidine in which one of the methyl groups attached to the nitrogen is replaced by hydrogen. ent-Dextilidine is metabolised to (1R,2S)-nortilidine by the liver.

What is the CAS number of Nortilidine?

The CAS registry number of Nortilidine is 38677-94-0.

What is the molecular formula and weight of Nortilidine?

The molecular formula of Nortilidine is C16H21NO2 and its molar mass is 259.35 g/mol.

What is Nortilidine used for?

Known uses and roles of Nortilidine include building blocks in research and laboratory, screening compounds in research and laboratory, nmda receptor antagonist, animal metabolite, antagonist and 8 more.

Is Nortilidine hazardous?

No GHS hazard classification for Nortilidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Nortilidine?

Nortilidine is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nortilidine?

Post a free request on CompoundList and suppliers of Nortilidine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Nortilidine?

Suppliers quote Nortilidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nortilidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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