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Cardiovascular and metabolic drugs

Ramipril

Also known as Altace, Tritace, Triatec

CAS 87333-19-5Formula C23H32N2O5Molar mass 416.52 g/molEC 642-904-3
GHS signal word: Danger. Pictograms: Serious health hazard 131 suppliers listed Drug substance
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Ramipril chemical structure, C23H32N2O5, CAS 87333-19-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Felty needles from ether
Melting point
109 °C
Solubility
Sparingly soluble in water
HS code
293399
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ramipril?

Plain description, key identifiers and synonyms

Ramipril is a dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug, a matrix metalloproteinase inhibitor, a cardioprotective agent and a bradykinin receptor B2 agonist. It is an ethyl ester, a dicarboxylic acid monoester, an azabicycloalkane, a cyclopentapyrrole and a dipeptide. It is a conjugate acid of a ramipril(1-).

Ramipril is a pharmaceutical compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
CAS number
87333-19-5 CAS number cross-checkedOther or deprecated CAS: 1028843-43-7
EC number
642-904-3
Molecular formula
C23H32N2O5
UNII
L35JN3I7SJ
MDL number
MFCD00865775
InChIKey
HDACQVRGBOVJII-JBDAPHQKSA-N
InChI
InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
Canonical SMILES
CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(C(=O)O)CC2CCCC21
Isomeric SMILES
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O

Synonyms

  • Altace
  • Tritace
  • Triatec
  • Ramace
  • Vesdil
  • Delix
  • Cardace
  • Acovil
  • Pramace
  • Hoe-498
  • Ramiprilum
  • Unipril
  • HOE 498
  • Corpril
  • Ramipres
  • Ecator
  • Hopace
  • (2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, 1-ethyl ester
  • (2S,3aS,6aS)-1-((S)-N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrol-2-carbonsaeure
  • Ramiprilum (Latin)
  • (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid
  • Cyclopenta(b)pyrrole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-
  • Zabien
  • Cyclopenta(b)pyrrole-2-carboxylic acid, 1-((2S)-2-(((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3as,6as)-
Show all 37 synonyms
  • Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,6aS)-
  • Ranace
  • (2S,3aS,6aS)-1-((2S)-2-(((2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta(d)pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-((2S)-2-(((2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-octahydrocyclopenta(b)pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[d]pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid, 1-ethyl ester
  • Carasel
  • Quark
  • Altace (TN)
  • (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
  • Lostapres
  • Hytren

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Felty needles from etherexp.
Melting point
109 °Cexp.
Solubility
Sparingly soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
416.52 g/molcalc.
Exact mass
416.2311 Dacalc.
LogP (octanol/water)
2.38calc.
Topological polar surface area
95.94 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
9calc.
Heavy atoms
30calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.61calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNCCCc1ccccc1)N1CCC2CCCC21

O=C(CNCCCc1ccccc1)N1CCC2CCCC21

3 rings, 21 atoms.

25 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ramipril suppliers

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All 131 suppliers
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Where suppliers are based

131 suppliers in 21 countries

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Ramipril price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents.

Industries and functions

Pharmacological actions

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents

Roles

  • agonist
  • anti-arrhythmia drug
  • antiatherosclerotic agent
  • antihypertensive agent
  • antimicrobial agent
  • antirheumatic drug
  • antiviral agent
  • bradykinin receptor B2 agonist
  • bradykinin receptor agonist
  • cardioprotective agent
  • cardiovascular drug
  • enzyme inhibitor
  • hypoglycemic agent
  • matrix metalloproteinase inhibitor
  • pharmaceutical
  • pro-agent
  • prodrug
  • protective agent
  • renoprotective agent

Pharmacology

Ramipril is an Angiotensin Converting Enzyme Inhibitor. The mechanism of action of ramipril is as an Angiotensin-converting Enzyme Inhibitor.

How it is made

Preparation: V. Teetz et al., European Patent Office patent 79022 (1983 to Hoechst) ... E. H. Gold et al., United States of America patent 4587258 (1986 to Schering Corp.).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ramipril is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ramipril is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ramipril, based on the data on this page

What is Ramipril?

Ramipril is a dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

What is the CAS number of Ramipril?

The CAS registry number of Ramipril is 87333-19-5. Other or deprecated CAS numbers: 1028843-43-7.

What is the molecular formula and weight of Ramipril?

The molecular formula of Ramipril is C23H32N2O5 and its molar mass is 416.52 g/mol.

What is Ramipril used for?

Veterinary medication:. Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents.

Is Ramipril hazardous?

Ramipril carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ramipril?

Ramipril is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ramipril?

CompoundList lists 131 suppliers of Ramipril in India, United States, China, Germany and 17 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ramipril in India?

37 suppliers in India list Ramipril on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ramipril?

Suppliers quote Ramipril on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ramipril

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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