CompoundList
Sign in
Heterocyclic compounds

Retrorsine

Also known as beta-Longilobine, cis-Retronecic acid ester of retronecine, 12,18-Dihydroxy-senecionan-11,16-dione

CAS 480-54-6Formula C18H25NO6Molar mass 351.40 g/molEC 610-403-9
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 3 suppliers listed
Get quotes Compare 3 suppliers
Retrorsine chemical structure, C18H25NO6, CAS 480-54-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless prisms
Melting point
212 °C
Solubility
Soluble in chloroform, slightly soluble in acetone, ethanol, water
HS code
293499
Category
Heterocyclic compounds
Illustrative photo, colourless crystals in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Retrorsine?

Plain description, key identifiers and synonyms

Retrorsine is a macrolide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
CAS number
480-54-6 CAS number cross-checked
EC number
610-403-9
Molecular formula
C18H25NO6
UNII
XJ86XWL8IY
InChIKey
BCJMNZRQJAVDLD-CQRYIUNCSA-N
InChI
InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1
Canonical SMILES
CC=C1CC(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23
Isomeric SMILES
C/C=C\1/C[C@H]([C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(CO)O)C

Synonyms

  • beta-Longilobine
  • cis-Retronecic acid ester of retronecine
  • 12,18-Dihydroxy-senecionan-11,16-dione
  • Senecionan-11,16-dione, 12,18-dihydroxy-
  • trans-15-Ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1-enine
  • 3-Ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione
  • (1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
  • (1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo(9.5.1.014,17)heptadec-11-ene-3,8-dione
  • 12,18-Dihydroxysenecionan-11,16-dione
  • Retrorsin
  • (15Z)-12,18-dihydroxysenecionan-11,16-dione
  • Retrorcine
  • Retrorsine (Standard)
  • Retrorsine, >=90% (HPLC)
  • Retrorsine 100 microg/mL in Water
  • (Z)-ethylidene-hydroxy-(hydroxymethyl)-methyl-[?]dione
  • (1R,4Z,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0??,??]heptadec-11-ene-3,8-dione
  • (7S,1R,6R,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14- azatricyclo[9.5.1.0<14,17>]heptadec-11-ene-3,8-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless prismsexp.
Melting point
212 °Cexp.
Solubility
Soluble in chloroform, slightly soluble in acetone, ethanol, waterexp.
Vapour pressure
1.9 × 10⁻¹⁴ mm Hg @ 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
351.40 g/molcalc.
Exact mass
351.1682 Dacalc.
LogP (octanol/water)
0.17calc.
Topological polar surface area
96.3 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
1calc.
Heavy atoms
25calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1CCCC(=O)OCC2=CCN3CCC(OC1=O)C23

C=C1CCCC(=O)OCC2=CCN3CCC(OC1=O)C23

3 rings, 20 atoms.

34 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Retrorsine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 2 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Retrorsine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Some of the Senecio species in which it occurs have been used as medicinal herbs, eg, S. discolor (SW)DC was used against coughs, colds, fevers and indigestion in Jamaica, S. bupleuroids DC was reported to be an ingredient in an African remedy for chest troubles, and S. vulgaris was used in Europe for dysmenorrhea and amenorrhea and in the U.S. as a diaphoretic, diuretic, tonic and emmenagogue. S isatideue is a high-yielding source suitable for preparative purposes.

Pharmacological actions

  • Antineoplastic Agents, Phytogenic

How it is made

Not produced commercially.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Retrorsine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Retrorsine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Retrorsine, based on the data on this page

What is Retrorsine?

Retrorsine is a macrolide.

What is the CAS number of Retrorsine?

The CAS registry number of Retrorsine is 480-54-6.

What is the molecular formula and weight of Retrorsine?

The molecular formula of Retrorsine is C18H25NO6 and its molar mass is 351.40 g/mol.

What is Retrorsine used for?

Some of the Senecio species in which it occurs have been used as medicinal herbs, eg, S. discolor (SW)DC was used against coughs, colds, fevers and indigestion in Jamaica, S. bupleuroids DC was reported to be an ingredient in an African remedy for chest troubles, and S.

Is Retrorsine hazardous?

Retrorsine carries the GHS signal word "Danger". Main hazards: fatal if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Retrorsine?

Retrorsine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Retrorsine?

CompoundList lists 3 suppliers of Retrorsine in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Retrorsine?

Suppliers quote Retrorsine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Retrorsine

Get quotes for Retrorsine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Retrorsine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Retrorsine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/retrorsine-480-54-6" title="Retrorsine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Heterocyclic compounds or HS code 293499

3 suppliers
Free quotes, contact stays private
Get quotes