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Impurities and reference standards

Senecionine

Also known as Aureine, Senecionin, 12-Hydroxysenecionan-11,16-dione

CAS 130-01-8Formula C18H25NO5Molar mass 335.40 g/molEC 603-379-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 5 suppliers listed
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Senecionine chemical structure, C18H25NO5, CAS 130-01-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Plates
Melting point
236 °C
Solubility
Practically insol in water, freely sol in chloroform, slightly sol in alc, ether
HS code
293979
Category
Impurities and reference standards
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Senecionine?

Plain description, key identifiers and synonyms

Senecionine is a pyrrolizidine alkaloid isolated from the plant species of the genus Senecio. It has a role as a plant metabolite. It is a lactone, a tertiary alcohol and a pyrrolizidine alkaloid. It is functionally related to a senecionan. It is a conjugate base of a senecionine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1R,4Z,6R,7R,17R)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
CAS number
130-01-8 CAS number cross-checked
EC number
603-379-6
Molecular formula
C18H25NO5
UNII
BO6N1U5YG6
MDL number
MFCD00221720
InChIKey
HKODIGSRFALUTA-JTLQZVBZSA-N
InChI
InChI=1S/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-/m1/s1
Canonical SMILES
CC=C1CC(C)C(C)(O)C(=O)OCC2=CCN3CCC(OC1=O)C23
Isomeric SMILES
C/C=C\1/C[C@H]([C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(C)O)C

Synonyms

  • Aureine
  • Senecionin
  • 12-Hydroxysenecionan-11,16-dione
  • Senecionan-11,16-dione, 12-hydroxy-
  • (-)-Senecionine
  • (1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,14aR,14bR)-
  • [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,14aR,14bR)-
  • (1R,4Z,6R,7R,17R)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione
  • (1R,4Z,6R,7R,17R)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo(9.5.1.014,17)heptadec-11-ene-3,8-dione
  • (5R,6R,9a1R,14aR,Z)-3-ethylidene-6-hydroxy-5,6-dimethyl-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
  • Aureine\, Senecionin
  • Senecionine (Standard)
  • Senecionine Impurity 1
  • Senecionan-11, 12-hydroxy-
  • Senecionine, analytical standard
  • Senecionine, >=95.0% (GC)
  • (Z)-ethylidene-hydroxy-dimethyl-[?]dione
  • (15Z)-12-hydroxysenecionan-11,16-dione
  • Senecionine 100 microg/mL in Methanol:Water
  • (1R,4Z,6R,7R,17R)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.0,14,17]heptadec-11-ene-3,8-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Platesexp.
Taste
Bitterexp.
Melting point
236 °Cexp.
Solubility
Practically insol in water, freely sol in chloroform, slightly sol in alc, etherexp.
Vapour pressure
1.8 × 10⁻¹² mm Hg @ 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
335.40 g/molcalc.
Exact mass
335.1733 Dacalc.
LogP (octanol/water)
1.19calc.
Topological polar surface area
76.07 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
0calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1CCCC(=O)OCC2=CCN3CCC(OC1=O)C23

C=C1CCCC(=O)OCC2=CCN3CCC(OC1=O)C23

3 rings, 20 atoms.

34 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Senecionine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
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Where suppliers are based

5 suppliers in 2 countries

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Senecionine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Senecio herb is used (as a folk remedy) for diabetes mellitus, hemorrhage, high blood pressure, for spasms, and as a uterine stimulant.

Pharmacological actions

  • Antineoplastic Agents, Phytogenic

Roles

  • eukaryotic metabolite
  • metabolite
  • plant metabolite

How it is made

From whole plant of senecio vulgaris l, compositae and several other senecio spp.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Senecionine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Senecionine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Senecionine, based on the data on this page

What is Senecionine?

Senecionine is a pyrrolizidine alkaloid isolated from the plant species of the genus Senecio. It has a role as a plant metabolite. It is a lactone, a tertiary alcohol and a pyrrolizidine alkaloid. It is functionally related to a senecionan. It is a conjugate base of a senecionine(1+).

What is the CAS number of Senecionine?

The CAS registry number of Senecionine is 130-01-8.

What is the molecular formula and weight of Senecionine?

The molecular formula of Senecionine is C18H25NO5 and its molar mass is 335.40 g/mol.

What is Senecionine used for?

Senecio herb is used (as a folk remedy) for diabetes mellitus, hemorrhage, high blood pressure, for spasms, and as a uterine stimulant.

Is Senecionine hazardous?

Senecionine carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Senecionine?

Senecionine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Senecionine?

CompoundList lists 5 suppliers of Senecionine in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Senecionine?

Suppliers quote Senecionine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Senecionine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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