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Screening compounds

Rintodestrant

Also known as Rintodestrant (USAN), 2-Propenoic acid, 3-(4-((2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxybenzo(b)thien-3-yl)oxy)phenyl)-, (2E)-, (2E)-3-(4-((2-(4-Fluoro-2,6-dimethylbenzoyl)-6-hydroxy-1-benzothiophen-3-yl)oxy)phenyl)prop-2-enoic acid

CAS 2088518-51-6Formula C26H19FO5SMolar mass 462.50 g/mol
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Rintodestrant chemical structure, C26H19FO5S, CAS 2088518-51-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2088518-51-6
Formula
C26H19FO5S
Molar mass
462.50 g/mol
HS code
293499
Category
Screening compounds

What is Rintodestrant?

Plain description, key identifiers and synonyms

Rintodestrant is an orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, rintodestrant specifically targets and binds to the estrogen receptor alpha (ERalpha, ERa, ESR1) and induces a conformational change that promotes ERalpha degradation and downregulation. This prevents ERalpha-mediated signaling and inhibits both the growth and survival of ERalpha-expressing cancer cells.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(E)-3-[4-[[2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxy-1-benzothiophen-3-yl]oxy]phenyl]prop-2-enoic acid
CAS number
2088518-51-6
Molecular formula
C26H19FO5S
UNII
W3Y784Y0ES
InChIKey
KOAITBOFZOEDOC-BJMVGYQFSA-N
InChI
InChI=1S/C26H19FO5S/c1-14-11-17(27)12-15(2)23(14)24(31)26-25(20-9-6-18(28)13-21(20)33-26)32-19-7-3-16(4-8-19)5-10-22(29)30/h3-13,28H,1-2H3,(H,29,30)/b10-5+
Canonical SMILES
Cc1cc(F)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(C=CC(=O)O)cc1
Isomeric SMILES
CC1=CC(=CC(=C1C(=O)C2=C(C3=C(S2)C=C(C=C3)O)OC4=CC=C(C=C4)/C=C/C(=O)O)C)F

Synonyms

  • Rintodestrant (USAN)
  • 2-Propenoic acid, 3-(4-((2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxybenzo(b)thien-3-yl)oxy)phenyl)-, (2E)-
  • (2E)-3-(4-((2-(4-Fluoro-2,6-dimethylbenzoyl)-6-hydroxy-1-benzothiophen-3-yl)oxy)phenyl)prop-2-enoic acid
  • (2E)-3-(4-{[2-(4-Fluoro-2,6-dimethylbenzoyl)-6-hydroxy-1-benzothiophen-3-yl]oxy}phenyl)prop-2-enoic acid
  • SERD G1T48
  • Selective Estrogen Receptor Degrader G1T48
  • Selective Estrogen Receptor Downregulator G1T48
  • (E)-3-[4-[[2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxy-1-benzothiophen-3-yl]oxy]phenyl]prop-2-enoic acid
  • WHO 11394
  • Rintodestrant (Synonyms: G1T48)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
462.50 g/molcalc.
Exact mass
462.0937 Dacalc.
LogP (octanol/water)
6.48calc.
Topological polar surface area
83.83 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
33calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccc1)c1sc2ccccc2c1Oc1ccccc1

O=C(c1ccccc1)c1sc2ccccc2c1Oc1ccccc1

4 rings, 24 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rintodestrant suppliers

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Rintodestrant price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rintodestrant is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Rintodestrant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rintodestrant, based on the data on this page

What is Rintodestrant?

Rintodestrant is an orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity.

Guides for buyers

Practical guides that help when you source, ship or handle Rintodestrant

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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