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Screening compounds

Ripasudil

Also known as 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline, K-321 anhydrous free base, 1H-1,4-Diazepine, 1-((4-fluoro-5-isoquinolinyl)sulfonyl)hexahydro-2-methyl-, (2S)-

CAS 223645-67-8Formula C15H18FN3O2SMolar mass 323.39 g/mol
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Ripasudil chemical structure, C15H18FN3O2S, CAS 223645-67-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
223645-67-8
Formula
C15H18FN3O2S
Molar mass
323.39 g/mol
HS code
293590
Category
Screening compounds

What is Ripasudil?

Plain description, key identifiers and synonyms

Ripasudil is a member of isoquinolines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
CAS number
223645-67-8 CAS number cross-checked
Molecular formula
C15H18FN3O2S
UNII
11978226XX
MDL number
MFCD28291829
InChIKey
QSKQVZWVLOIIEV-NSHDSACASA-N
InChI
InChI=1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1
Canonical SMILES
CC1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12
Isomeric SMILES
C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F

Synonyms

  • 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline
  • K-321 anhydrous free base
  • 1H-1,4-Diazepine, 1-((4-fluoro-5-isoquinolinyl)sulfonyl)hexahydro-2-methyl-, (2S)-
  • Isoquinoline, 4-fluoro-5-(((2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl)sulfonyl)-
  • ripasudilum
  • 4-fluoro-5-(((2S)-2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
  • 1H-1,4-Diazepine, 1-[(4-fluoro-5-isoquinolinyl)sulfonyl]hexahydro-2-methyl-, (2S)-
  • Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-
  • K-115 free base
  • k115 Free base
  • Ripasudil free base
  • (S)-4-Fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
  • Ripasudil (USAN/INN)
  • K-115 anhydrous free base
  • K-115 (ripasudil hydrochloride dihydrate)
  • (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl-1,4-homopiperazine
  • 4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
323.39 g/molcalc.
Exact mass
323.1104 Dacalc.
LogP (octanol/water)
1.75calc.
Topological polar surface area
62.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(c1cccc2cnccc12)N1CCCNCC1

O=S(=O)(c1cccc2cnccc12)N1CCCNCC1

3 rings, 20 atoms, the Fasudil ring system.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ripasudil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 1 country

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Ripasudil price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ripasudil is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ripasudil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ripasudil, based on the data on this page

What is Ripasudil?

Ripasudil is a member of isoquinolines.

What is the CAS number of Ripasudil?

The CAS registry number of Ripasudil is 223645-67-8.

What is the molecular formula and weight of Ripasudil?

The molecular formula of Ripasudil is C15H18FN3O2S and its molar mass is 323.39 g/mol.

What is Ripasudil used for?

Known uses and roles of Ripasudil include building blocks in research and laboratory and screening compounds in research and laboratory.

Is Ripasudil hazardous?

No GHS hazard classification for Ripasudil is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ripasudil?

Ripasudil is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ripasudil?

CompoundList lists 3 suppliers of Ripasudil in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ripasudil?

Suppliers quote Ripasudil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ripasudil

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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