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Central nervous system drugs

Rotigotine

Also known as Neupro, Leganto, SPM 962

CAS 99755-59-6Formula C19H25NOSMolar mass 315.48 g/molEC 619-458-3
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 79 suppliers listed Drug substance
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Rotigotine chemical structure, C19H25NOS, CAS 99755-59-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
99755-59-6
Formula
C19H25NOS
Appearance
White to off-white powder
Solubility
Lipophilic and poorly soluble in water at neutral pH. Solubility increases at more acidi…
HS code
293499
Category
Central nervous system drugs
Illustrative photo, fine white powder in an amber glass reagent bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Rotigotine?

Plain description, key identifiers and synonyms

Rotigotine is a member of tetralins.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
CAS number
99755-59-6 CAS number cross-checked
EC number
619-458-3
Molecular formula
C19H25NOS
UNII
87T4T8BO2E
MDL number
MFCD00870193
InChIKey
KFQYTPMOWPVWEJ-INIZCTEOSA-N
InChI
InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
Canonical SMILES
CCCN(CCc1cccs1)C1CCc2c(O)cccc2C1
Isomeric SMILES
CCCN(CCC1=CC=CS1)[C@H]2CCC3=C(C2)C=CC=C3O

Synonyms

  • Neupro
  • Leganto
  • SPM 962
  • Rotigotina
  • (6S)-6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol
  • (-)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
  • (6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol
  • 1-naphthalenol, 5,6,7,8-tetrahydro-6-(propyl (2-(2-thienyl)ethyl)amino-(6S)-
  • (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
  • rotigotinum
  • (6S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
  • rotigotine, (+--)-
  • (+--)-5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
  • 1-Naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-
  • (S)-6-(propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
  • (6s)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
  • (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
  • Rotigotine CDS Patch
  • Rotigotine CDS
  • Neupro (TN)
  • Rotigotine?
  • Rotigotine CRS
  • (6S)-rotigotine
  • 99755-59-6 (free base)
  • Rotigotine (Base)
Show all 28 synonyms
  • Rotigotine (Standard)
  • (2S)-2-[propyl-[2-(2-thienyl)ethyl]amino]tetralin-5-ol
  • Rotigotine (JAN/USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white powderexp.
Solubility
Lipophilic and poorly soluble in water at neutral pH. Solubility increases at more acidic pH.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.48 g/molcalc.
Exact mass
315.1657 Dacalc.
LogP (octanol/water)
4.27calc.
Topological polar surface area
23.47 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.47calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1csc(CCNC2CCc3ccccc3C2)c1

c1csc(CCNC2CCc3ccccc3C2)c1

3 rings, 18 atoms.

36 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Rotigotine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 79 suppliers
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Where suppliers are based

79 suppliers in 17 countries

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Rotigotine price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Dopamine Agonists.

Industries and functions

Pharmacological actions

  • Dopamine Agonists

Roles

  • antidyskinesia agent
  • antiparkinson drug
  • pharmaceutical

Pharmacology

Rotigotine is a Nonergot Dopamine Agonist. The mechanism of action of rotigotine is as a Dopamine Agonist.

How it is made

Improved synthesis: G. Minaskanian, K. Rippel, United States of America patent 6372920 (2002 to Aderis).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rotigotine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Rotigotine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rotigotine, based on the data on this page

What is Rotigotine?

Rotigotine is a member of tetralins.

What is the CAS number of Rotigotine?

The CAS registry number of Rotigotine is 99755-59-6.

What is the molecular formula and weight of Rotigotine?

The molecular formula of Rotigotine is C19H25NOS and its molar mass is 315.48 g/mol.

What is Rotigotine used for?

Dopamine Agonists.

Is Rotigotine hazardous?

Rotigotine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause drowsiness or dizziness, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Rotigotine?

Rotigotine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rotigotine?

CompoundList lists 79 suppliers of Rotigotine in China, United States, India, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Rotigotine in India?

8 suppliers in India list Rotigotine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Rotigotine?

Suppliers quote Rotigotine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rotigotine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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