Saccharin
Also known as o-Benzoic sulfimide, o-Sulfobenzimide, Saccharine
Key facts
What buyers check first
- Appearance
- Monoclinic crystals
- Melting point
- 228 °C
- Boiling point
- Sublimes
- Density
- 0.828 g/cm³ at 25 °C
- Solubility
- 1 G SOL IN 2.6 ML WATER, 4.7 ML ALC /CALCIUM SALT/.
- HS code
- 292511
- Category
- Sweeteners
What is Saccharin?
Plain description, key identifiers and synonyms
Saccharin is a 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent. It has a role as a xenobiotic, a sweetening agent and an environmental contaminant. It is a 1,2-benzisothiazole and a N-sulfonylcarboxamide.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 1,1-dioxo-1,2-benzothiazol-3-one
- CAS number
- 81-07-2 CAS number cross-checked
- EC number
- 201-321-0
- Molecular formula
- C7H5NO3S
- UNII
- FST467XS7D
- MDL number
- MFCD00005866
- INCI name
- SACCHARIN
- InChIKey
- CVHZOJJKTDOEJC-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
- SMILES (canonical and isomeric)
- C1=CC=C2C(=C1)C(=O)NS2(=O)=O
Synonyms
- o-Benzoic sulfimide
- o-Sulfobenzimide
- Saccharine
- Saccharimide
- Benzosulfimide
- Garantose
- o-Benzosulfimide
- Benzoic sulfimide
- Benzosulphimide
- Saccharinol
- Saccharinose
- Saccharin insoluble
- Benzosulfinide
- Hermesetas
- Saccharol
- Glucid
- Gluside
- Saccharin acid
- 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide
- Benzoic sulphimide
- Kandiset
- Sacarina
- Sucrette
- Zaharina
- Sykose
Show all 39 synonymsShow fewer synonyms
- Saxin
- o-Benzoyl sulfimide
- Sucre edulcor
- Benzo-2-sulphimide
- o-Benzoic sulphimide
- Benzoylsulfonic Imide
- o-Benzosulphimide
- o-Sulfobenzoic acid imide
- Insoluble saccharin
- 550 Saccharine
- Anhydro-o-sulfaminebenzoic acid
- Natreen
- Sacharin
- o-Benzoyl sulphimide
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Monoclinic crystalsexp.Measured value |
|---|---|
| Odour | ODORLESS OR HAS FAINT AROMATIC ODOR.exp.Measured value |
| Taste | In dilute aqueous solution it is 500 times as sweet as sugar, sweet taste detectable in 1:100,000 dilution.exp.Measured value |
| Melting point | 228 °Cexp.Measured value |
| Boiling point | Sublimesexp.Measured value |
| Density | 0.828 g/cm³ at 25 °Cexp.Measured value |
| Solubility | 1 G SOL IN 2.6 ML WATER, 4.7 ML ALC /CALCIUM SALT/.exp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 183.19 g/molcalc.Computed value |
|---|---|
| Exact mass | 182.999 Dacalc.Computed value |
| LogP (octanol/water) | 0.12calc.Computed value |
| Topological polar surface area | 63.24 Ųcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 3calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 12calc.Computed value |
| Rings | 2calc.Computed value |
| Aromatic rings | 1calc.Computed value |
| Fraction sp3 carbons | 0calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C1NS(=O)(=O)c2ccccc21
2 rings, 12 atoms. This chemical is the scaffold itself.
263 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidSaccharin suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- India, Navi Mumbai ManufacturerUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- Price on request
- United StatesUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- India, Padra ManufacturerUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- India ManufacturerUnclaimed profileSaccharineGrade, purity and minimum order on requestPrice on request
- India, ChennaiUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- South Korea ManufacturerUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- China ManufacturerUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
- RussiaUnclaimed profileSaccharinGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
121 suppliers in 27 countries
- United States35
- China27
- Germany6
- United Kingdom6
- India6
- Spain5
- and 21 more countries
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Saccharin price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Non-nutritive sweetener, pharmaceutic aid (flavor). In formulations for electroplating-bath brighteners.
A sweetening agent in Aromatic Cascara Sagrada Fluid extract and highly alcoholic preparations. ... It is used as a sweetening agent in vehicles, canned foods, and beverages and in diets for diabetics to replace sucrose.
Add sweetness with or without the extra calories ... (in) beverages, baked goods, confections, table-top sugar, substitutes, many processed foods.
Non-caloric synthetic sweetener in tablets, liq products, soft drinks, dietetic foods, misc pharmaceuticals, chewing gum, tooth paste, smokeless tobacco products, electroplating bath additive, cattle feed additive, antiseptic (former use), preservative to retard fermentation of food (former use).
Saccharin has been used in the sweetening of pharmaceutical tablets and in processing of tobacco.
Use classes: Pesticide transformation products, Cosmetics.
Industries and functions
Cosmetic ingredient, INCI name SACCHARIN(fragrance, oral care)
Pharmacological actions
- Sweetening Agents
Roles
- additive
- anticonvulsant
- central nervous system depressant
- central nervous system drug
- environmental contaminant
- flavouring agent
- food additive
- food component
- pharmaceutical
- physiological role
- sweetening agent
- xenobiotic
Functional uses
- Deodorizer
- Flavouring and nutrient
- Fragrance
Cosmetic functions
- Fragrance
- Oral care
How it is made
In most countries, commercial saccharin is produced by the Remsen-Fahlberg process ... Toluene is used as the starting material and reacted with chlorosulfonic acid to a mixture of isomeric toluene sulfochlorides. In the presence of ammonia, 2-toluene sulfochloride forms 2-toluene sulfonic acid amide which is oxidized under appropriate conditions to saccharin. Potential oxidizing agents are potassium permanganate or chromic acid.
In the United States, the Maumee process is used. This starts from either anthranilic acid or its methyl ester, which can be obtained from phthalic acid anhydride.
Read more
With sodium nitrite, anthranilic acid forms a diazonium compound, which is reacted with sulfur dioxide or sulfites, and chlorinated to 2-chlorosulfonylbenzoic acid methyl ester. In the presence of ammonia, this ester yields the respective amide, from which, after de-esterification, saccharin is obtained. Reaction with sodium hydroxide or calcium hydroxide forms the respective saccharin salts.
Saccharin is dissolved in an equimolar quantity of aqueous sodium hydroxide, and the solution is concentrated to crystallization. (Saccharin sodium)
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- EU cosmetic ingredient inventory
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Saccharin is traded under.
Saccharin and its salts
- China56.4%
- South Korea14.5%
- Germany7.7%
- United States12.1%
- Germany9.7%
- Thailand7.8%
The HS code shown for Saccharin is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
Same formula isomers
Different compounds that share this molecular formula
![5-Methyl-2H-thieno[2,3-d][1,3]oxazine-2,4(1H)-dione chemical structure, C7H5NO3S, CAS 109666-88-8](/s/WBLHZJOTBCBRCB-UHFFFAOYSA-N.svg)
![1-Methyl-1H,2H,4H-thieno[3,2-d][1,3]oxazine-2,4-dione chemical structure, C7H5NO3S, CAS 103979-57-3](/s/ZBOLUTGJASWHGP-UHFFFAOYSA-N.svg)
![6-Methyl-2H-thieno[2,3-d][1,3]oxazine-2,4(1H)-dione chemical structure, C7H5NO3S, CAS 877142-62-6](/s/KUYVNJOOVJOKCR-UHFFFAOYSA-N.svg)
![Thieno[2,3-b]pyridin-3(2H)-one 1,1-Dioxide chemical structure, C7H5NO3S, CAS 2173565-54-1](/s/PURUKMLQZGUQMY-UHFFFAOYSA-N.svg)
Frequently asked questions
Quick answers about Saccharin, based on the data on this page
What is Saccharin?
What is the CAS number of Saccharin?
What is the molecular formula and weight of Saccharin?
What is Saccharin used for?
Is Saccharin hazardous?
What is the HS code of Saccharin?
Where can I buy Saccharin?
Where can I buy Saccharin in India?
What is the price of Saccharin?
Guides for buyers
Practical guides that help when you source, ship or handle Saccharin
- Article, QualityWhat a certificate of analysis should containThe parts of a complete COA, how to read it against your specification, the warning signs of a weak or copied certificate and how to verify results.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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